Sebaceous gland epithelioma with potential malignancy in a dog

Yıl 2024, , 333 - 336, 31.08.2024

Ömer Faruk Keleş , Yağmur Kuşçu , Caner Kayıkçı , Hacı Ahmet Çiçek

https://doi.org/10.24880/meditvetj.1541593

Öz

Sebaceous gland tumors consist of neoplastic proliferations of sebaceous gland cells located around hair follicles in the dermis. These tumors are subclassified as sebaceous epithelioma, sebaceous adenoma, sebaceous adenocarcinoma and nodular hyperplasia. In this case report, a nodular growth in the sacral region of an eight-year-old male Belgian Malinois dog was presented. Macroscopically, the nodular mass had a slightly soft consistency, grayish-white, and dark red-black appearance. The mass was measured in the dimension of 2x1x1 cm. Histopathologically, the tumor was observed to have a multilobular structure shaped by neoplastic cell islands. The tumor consisted mainly of eosinophilic cells with small cytoplasm resembling epithelial basaloid cells and to a lesser extent differentiated sebocytes. The parenchyma of the tumor consisted of irregular islets containing a small number of mature sebocytes. Their nuclei are oval with one to three small nucleoli. Immunohistochemically, tumor cells for Ki67 antibody showed strongly positive immunoreactivity. Based on the histopathological and immunohistochemical features, the tumor was diagnosed as sebaceous epithelioma having, a potential malignancy. Since no case of sebaceous epithelioma with malignant potential has been reported in our country, we aimed to present the case with histopathological and immunohistochemical features.

Anahtar Kelimeler

dog, histopathology, Ki67 immunoreactivity, sebaceous epithelioma

Kaynakça

• Amaravathi, M., Murthy, R., Naik, S., Nasreen, A., Srilatha, C., Sujatha, K., & Saibaba, M. (2017). Sebaceous gland adenocarcinoma in a dog. Journal of Livestock Science, 8, 18-20. ISSN No. (online) 2277-6214.
• Bettini, G., Morini, M., Mandrioli, L., Capitani, O., & Gandini, G. (2009). CNS and lung metastasis of sebaceous epithelioma in a dog. Veterinary Dermatology, 20(4), 289-294. https://doi.org/10.1111/j.1365-3164.2009.00762.x
• Cabral E.S., Auerbach A., Killian J.K., Barrett T.L., & Cassarino D.S. (2006). Distinction of benign sebaceous proliferations from sebaceous carcinomas by immuno-histochemistry. The American Journal of Dermatopathology, 28, 465–471. DOI: 10.1097/01.dad.0000245200.65600.a4
• Chen, W.C. & Zouboulis, C.C. (2009). Hormones and the pilosebaceous unit. Dermato-endocrinology, 1(2), 81-86. https://doi.org/10.4161/derm.1.2.8354 Goldschmidt M.H., Goldschmidt K.H. (2017). Epithelial and Melanocytic Tumors of the Skin. In: D. J. Meuten (Ed.). Tumors in Domestic Animals (pp. 88-141). Iowa State Press. https://doi.org/10.1002/9781119181200.ch4
• Graham, J.E., Kent, M.S., & Théon, A. (2004). Current therapies in exotic animal oncology. Veterinary Clinics: Exotic Animal Practice, 7(3), 757-781. https://doi.org/10.1016/j.cvex.2004.04.004
• Gross T.L., Ihrke P.J., Walder E.J., & Affolter V.K. (2005). Sebaceous tumors. In: Skin Diseases of the Dog and Cat. Clinical and Histopathologic Diagnosis. (2th ed., pp. 641-644). Blackwell Publishing. Doi: 10.1002/9780470752487
• Hendrick, M.J. (2016). Mesenchymal tumors of the skin and soft tissues. Tumors in domestic animals (pp. 142-175). https://doi.org/10.1002/9781119181200.ch5 Jakab, C. (2003). Histopathological analysis of tumours of the sebaceous gland in spaniels. Kisallat Praxis, 4, 36-38. https://eurekamag.com/research/003/795/003795973.php
• Rungsipipat, A., Sunyasootcharee, B., Ousawaphlangchai, L., Sailasuta, A., Thanawongnuwech, R., & Teankum, K. (2003). Neoplasms of dogs in Bangkok. The Thai Journal of Veterinary Medicine, 33(1), 59-66. thaijo.org/index.php/tjvm/article/view/37802
• Skelly, B.J., & Franklin, R.J. (2002). Recognition and diagnosis of lysosomal storage diseases in the cat and dog. Journal of veterinary internal medicine, 16(2), 133-141. https://doi.org/10.1111/j.1939-1676.2002.tb02344.x
• Vail, D.M., & Withrow, S.J. (2007). Tumors of the skin and subcutaneous tissues. Withrow, SJ; MacEewen, EG Small animal clinical oncology, 4, 375-401. https://doi.org/10.1016/B978-072160558-6.50021-6
• Yoon, J. S., & Park, J. (2016). Immunohistochemical characterization of sebaceous epithelioma in two dogs. Iranian Journal of Veterinary Research, 17, 134-136. PMCID: PMC5090144