Investigations of pancreas functions in dogs with chronic gastritis

Year 2025, Volume: 10 Issue: 2, 472 - 479, 31.08.2025

Yunus Emrah Aydınlık Halil İbrahim Gökçe

https://doi.org/10.24880/meditvetj.1673294

Abstract

The aim of the study was to determine whether pancreatitis develops in dogs with chronic gastritis. It was also aimed to investigate energy metabolism in dogs with chronic gastritis. Gastritis may occur primarily or secondarily due to diseases of surrounding organs and systems. Complications such as pancreatitis, hepatitis and nephritis may develop due to gastritis. In this study, gastroscopy was performed on dogs with suspected chronic gastritis and 20 dogs with gastric lesions were included in the study. In addition, 10 clinically healthy dogs with no gastroscopic lesions were used as the control group. Addionally, dogs with chronic gastritis were divided into two groups: hemorrhagic and non-hemorrhagic. Blood samples were collected from all dogs and serum samples were prepared and stored at -80oC until use. Canine specific amylase (AML), pancreatic lipase (cPL), insulin (INS), asprosin (ASP), glucose (GLU) and total cholesterol (total-C) values were measured in these serum samples. In the study, serum levels of cPL (p<0.05), INS (p<0.01), ASP (p<0.01), GLU (p<0.05) and total-C (p<0.01) were significatly higher in dogs with chronic gastritis than the values of dogs in the control group. There was no significant difference in AML levels of dogs with gastritis and control group. According to the cut-off values, increases in cPL, AML, INS, ASP, GLU and total-C values were determined in 12 (%60), 8 (%40), 15 (%75), 15 (%75), 11 (%55) and 13 (%65) dogs, respectively. While cPL values of dogs in the hemorrhagic gastritis group were determined to be statistically higher than those in the non-hemorrhagic group, increases in cPL values were also determined in more animals in this group. Additionally, a moderate positive correlation (p<0.05) was determined between cPL and ASP, a high positive correlation (p<0.01) was determined between AML and total-C, and between GLU and ASP. In conclusion, the results of the study showed that pancreatitis may develop in some dogs with chronic gastritis. In addition, increases in asprosin, insulin and total-C levels in dogs with chronic gastritis indicate that energy and lipid metabolisms are also affected.

Keywords

Amylase (AML) , asprosin , canine pancreatic lipase (cPL) , dog , gastritis

Project Number

0853-YL-22.

Gastritisli köpeklerde pankreas fonksiyonlarının araştırılması

Abstract

Çalışmanın amacı kronik gastritli köpeklerde pankreatit gelişip gelişmediğini belirlemektir. Ayrıca kronik gastritli köpeklerde enerji metabolizmasının araştırılması amaçlanmıştır. Gastrit, primer veya sekonder olarak çevredeki organ ve sistemlerin hastalıklarından kaynaklanabilir. Gastrite bağlı olarak da pankreatit, hepatit ve nefrit gibi komplikasyonlarda gelişebilir. Bu çalışmada kronik gastrit şüphesi olan köpeklere gastroskopi yapılmış ve gastrik lezyonu olan 20 köpek çalışmaya dahil edilmiştir. Ayrıca gastroskopik lezyonu olmayan klinik olarak sağlıklı 10 köpek kontrol grubu olarak kullanılmıştır. Ek olarak, kronik gastritli köpekler hemorajik ve hemorajik olmayan olmak üzere iki gruba ayrıldı. Tüm köpeklerden kan örnekleri toplandı ve serum örnekleri hazırlanarak kullanılıncaya kadar -80oC'de saklandı. Bu serum örneklerinde köpek spesifik amilaz (AML), pankreas lipaz (cPL), insülin (INS), asprosin (ASP), glukoz (GLU) ve toplam kolesterol (toplam-C) değerleri ölçüldü. Çalışmada, kronik gastritli köpeklerde cPL (p<0,05), INS (p<0,01), ASP (p<0,01), GLU (p<0,05) ve toplam-C (p<0,01) serum düzeylerinin kontrol grubundaki köpeklerin değerlerinden anlamlı olarak daha yüksek olduğu belirlendi. Gastritli köpeklerle kontrol grubu arasında AML düzeylerinde ise anlamlı bir fark bulunamadı. Cut-off değerlerine göre cPL, AML, INS, ASP, GLU ve total-C değerlerinde sırasıyla 12 (%60), 8 (%40), 15 (%75), 15 (%75), 11 (%55) ve 13 (%65) köpekte artış belirlendi. Hemorajik gastrit grubundaki köpeklerin cPL değerleri hemorajik olmayan gruba göre istatistiksel olarak yüksek bulunurken, bu grupta daha fazla sayıda hayvanda cPL değerlerinde artış belirlendi. Ayrıca cPL ile ASP arasında orta düzeyde pozitif korelasyon (p<0,05), AML ile total-C arasında ve GLU ile ASP arasında yüksek düzeyde pozitif korelasyon (p<0,01) belirlendi. Sonuç olarak çalışma sonuçları kronik gastritli bazı köpeklerde pankreatit gelişebileceğini göstermiştir. Ayrıca kronik gastritli köpeklerde asprosin, insülin ve total-C düzeylerindeki artışlar enerji ve lipid metabolizmalarının da etkilendiğini göstermektedir.

Keywords

Amilaz , asprosin , canine pancreatic lipase , köpek , gastritis

Project Number

0853-YL-22.

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