THE RADIOTHERAPY MIGHT BE A VACCINE FOR IMMMUN RESPONSE

Year 2019, , 94 - 105, 26.06.2019

Cengiz Kurtman , İryna Sokur Mahmut Kemal Ozbilgin

https://doi.org/10.23884/mejs.2019.5.1.10

Cited By: 1

Abstract

Radiotherapy (RT) is one of the most important treatment
options of cancer and also may activates immun response. Because of this we must discuss the question of “is the
radiotherapy vaccine”. If RT increases the immun response we must learn some
more about the RT effects on the cells, cell surface antigene, immun checkpoints
and their inhibition (ICI; CTLA4, PD1, PDL1 inhibition). It will be discussed the role of the radiotherapy and
biologic effects of the radiotherapy to activate the immun response, radiotherapy
dose, radiotherapy timing and the side effects of immun checkpoints inhibitors.
But with high conformal hypofractionated stereotactic radiotherapy the
microenvironment around the cancer tissue such as fibroblast may survives and then
may helps cancer stem cell progression.

Keywords

Radiotherapy, Immun Response

References

• Referans1 Doç.Dr.Binnaz Çelebioğlu, Kocaeli Üniversity Medical Faculty Department of Radiation OncologyReferans2 Doç.Dr.Burhanedtin Zincirlioğlu, Dicle University Medical Faculty Department of Radiation Oncology