manas j agr vet life sci Manas Journal of Agriculture Veterinary and Life Sciences 1694-7932 1694-7932 Kırgızistan Türkiye Manas Üniversitesi 10.53518/mjavl.1737446 Veterinary Histology and Embryology Veteriner Histoloji ve Embriyolojisi Isı Şoku Proteinleri: Mevcut Durum ve Gelecekteki Yönelimler Heat Shock Proteins: Current Status And Future Directions https://orcid.org/0009-0000-8942-6144 Yılmaz Kadriye KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, VETERİNER HEKİMLİĞİ TEMEL BİLİMLERİ BÖLÜMÜ, VETERİNERLİK HİSTOLOJİ VE EMBRİYOLOJİ ANABİLİM DALI https://orcid.org/0000-0001-7581-6109 Karadağ Sarı Ebru KAFKAS UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF BASIC SCIENCES VETERINARY MEDICINE, DEPARTMENT OF HISTOLOGY AND EMBRYOLOGY 12 25 2025 15 2 311 320 07 08 2025 09 19 2025 Copyright © 2013, Manas Journal of Agriculture Veterinary and Life Sciences 2013 Manas Journal of Agriculture Veterinary and Life Sciences

Canlılarda yaşamın sürekliliği ve hücresel olaylar, hücre içinde var olan mekanizmalar ile bu mekanizmalarda görev yapan moleküller aracılığı ile sağlanmaktadır. Organizmanın varlığını devam ettirerek çevreyle uyum içerisinde olmasının temel nedeni hücresel olaylarda rol alan moleküllerin kendi içlerinde etkileşimde olmasından kaynaklanmaktadır. Aminoasitlerin sayı, tür ve belirli diziliş şeklinde bir araya gelerek düz karakteristik bir zincirde peptid bağları ile birbirine bağlanmasıyla oluşan polipeptitlere protein adı verilmektedir. Proteinler ribozomda sentezlenir ve bu sentez sonucu polipeptitler meydana gelmektedir. Meydana gelen bu polipeptitler doğru biçimde katlanarak 3 boyutlu (3B) yapıya dönüşerek işlev kazanmaktadır Proteinler hücre olaylarındaki en önemli makromoleküllerdir Organizmada bulunan proteinlerin hatasız bir şekilde katlanması ve 3B yapısına ulaşması için yardımcı olan proteinlere “şaperon” adı verilmektedir. Birçok proteinin şaperon aktivitesine sahip olduğu ve ayrıca birçok şaperonun da stres proteini olarak görev yaptığı ve bunların en önemlisinin ısı stresine bağlı olarak artış gösteren ısı şok proteinleri (HSP) olduğu bildirilmiştir Bu derlememizde moleküler şaperonlar ve HSP hakkında bilgi verilmektedir. Ayrıca HSP’lerin yapısı ve üyeleri ayrı başlıklar altında incelenerek üyelerin özelliklerinden de bahsedilmektedir. HSP’nin görevlerinden ve Isı şok faktörlerinin özelliklerine de değinilmektedir.

The continuity of life and cellular processes in living organisms is facilitated by cellular mechanisms and the molecules that operate within these systems. The primary reason for an organism's continued existence and its harmony with the environment is the interaction of molecules involved in cellular processes. Proteins, which are polypeptides formed by the specific sequence and combination of amino acids linked by peptide bonds, are synthesized in the ribosome. These polypeptides undergo proper folding to acquire three-dimensional (3D) structures and functional capabilities. Proteins are crucial macromolecules in cellular processes. Proteins that assist other proteins in achieving flawless folding and attaining their 3D structure are termed "chaperones." It has been documented that numerous proteins exhibit chaperone activity and that many chaperones also function as stress proteins, with heat shock proteins (HSPs) being particularly significant due to their increase under heat stress. This review provides information on molecular chaperones and HSPs. Additionally, the structure and members of HSPs are examined under distinct headings, and the characteristics of these members are discussed. The functions of heat shock proteins and the attributes of heat shock factors are also addressed.

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