mmj Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 2148-8118 2618-6020 Muğla Sıtkı Koçman Üniversitesi Clinical Sciences (Other) Klinik Tıp Bilimleri (Diğer) Subklinik ve Aşikar Hipotiroid Hastalarda Serum Netrin-1, Nesfatin-1 ve Adropin Düzeylerinin Karşılaştırılması Comparing The Levels of Serum Netrin-1, Nesfatin-1 and Adropin in Subclinical and Overt Hypothyroid Patients https://orcid.org/0000-0003-2353-7284 Gemci Emine BURSA ŞEHİR HASTANESİ https://orcid.org/0000-0001-5849-0071 Akbaba Gülhan MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE https://orcid.org/0000-0002-0429-2317 Çınar Neşe MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE https://orcid.org/0000-0002-9300-9324 Edgünlü Tuba MUGLA SITKI KOCMAN UNIVERSITY, FACULTY OF MEDICINE https://orcid.org/0000-0003-3989-6965 Tosun Kursad Sienna College 04 29 2026 13 1 30 37 05 26 2025 02 26 2026 Copyright © 2014, Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 2014 Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Netrin-1, nesfatin-1 ve adropin; enerji homeostazı, inflamasyon, kardiyovasküler fonksiyon ve iştah düzenlemesi gibi fizyolojik süreçlerde rol oynayan düzenleyici peptitlerdir. Çalışmamız, aşikâr hipotiroidizm (AH) ve subklinik hipotiroidizm (SH) hastalarında serum netrin-1, nesfatin-1 ve adropin konsantrasyonlarını değerlendirerek; tiroid fonksiyon testleri ve metabolik parametrelerle ilişkilerini incelemek amacıyla tasarlanmıştır. Bu boşluğu ele alarak, araştırmamız bu moleküllerin tiroid ilişkili metabolik düzensizliklerdeki olası rolünün daha iyi anlaşılmasına katkıda bulunmayı amaçlamaktadır. Bu tek merkezli kesitsel çalışma prospektif olarak gerçekleştirilmiştir. Çalışmamıza 27 AH hastası, 29 SH hastası ve 27 kontrol grubu olmak üzere 83 kişi dahil edildi. Vücut kitle indeksi (VKİ), bel çevresi (BÇ), serbest triiodothyronin (sT3), serbest tiroksin (sT4), tiroid stimüle edici hormon (TSH), tiroid peroksidaz antikoru (anti-TPO), tiroglobulin antikoru (anti-TG), açlık kan şekeri (AKŞ), insülin, homeostatik model değerlendirmesi (HOMA-IR), trigliserid (TG), total kolesterol (TOTAL-K), düşük dansiteli kolesterol (LDL-K), çok düşük dansiteli kolesterol (VLDL-K), yüksek dansiteli kolesterol (HDL-K), C reaktif protein (CRP), Netrin-1, Nesfatin-1, Adropin ölçüldü. BKİ, BÇ, TSH, anti-TPO, AKŞ, TOTAL-K ve LDL-K düzeyleri AH grubunda kontrol grubuna göre anlamlı olarak daha yüksekti (sırasıyla p=0,014, p=0,007, p

Netrin-1, nesfatin-1, and adropin are regulatory peptides that play significant roles in energy homeostasis, inflammation, cardiovascular function, and appetite regulation. The present study was designed to assess serum concentrations of netrin-1, nesfatin-1 and adropin in patients with overt hypothyroidism (OH) and subclinical hypothyroidism (SH), and to examine their relationships with thyroid function tests and metabolic parameters. This single-center, cross-sectional study was performed prospectively. A total of 83 people: 27 OH patients, 29 SH patients and 27 control group were included in our study. Body mass index (BMI), WC (waist circumference), free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (anti-TPO), anti thyroglobulin (anti-TG), fasting blood glucose (FBG), insülin, homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride (TG), total cholesterol (TOTAL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), Netrin-1, Nesfatin-1, Adropin were measured. The BMI, WC, TSH, anti-TPO, FBG, TOTAL-C and LDL-C levels were significantly higher in the OH group than in the control group (p=0.014, p=0.007, p

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