Araştırma Makalesi
BibTex RIS Kaynak Göster

A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values

Yıl 2017, Cilt: 4 Sayı: 2, 17 - 23, 01.08.2017

Öz

To evaluate the
clinical utility of ADC values of axillary lymph nodes using high-resolution
axillary MR. 18 women with invasive breast carcinoma underwent axillary MR with
surface coils. Two radiologists determined the most suspicious axillary lymph
node using predefined morphologic descriptors and measured the ADC values of
the most suspicious lymph node in consensus. Statistical analysis was performed
to evaluate the diagnostic value of ADC measurements using the pathologic
assessment as the reference study. Histopathologic findings revealed axillary
nodal metastases in 11 out of 18 patients. ADC values of metastatic lymph nodes
were lower than the nonmetastatic nodes (p=0.006, Mann Whitney U test). By
using 0.967x10-3 mm2/s as a threshold, sensitivity,
specificity, accuracy, positive predictive value, and negative predictive
values based for ADC were 85.7, 100.0, 94.4, 91.7, 100.0. If our initial
results are confirmed with larger series, ADC values of the axillary lymph
nodes with high-resolution axillary MRI can be an alternative for sentinel
lymph node biopsy.

Kaynakça

  • 1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2009;59(4):225-49.
  • 2. Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin. 2006;56(1):37-47.
  • 3. Crippa F, Gerali A, Alessi A, Agresti R, Bombardieri E. FDG-PET for axillary lymph node staging in primary breast cancer. Eur J Nucl Med Mol Imaging. 2004;31(Suppl 1):97-102.
  • 4. Meinel LA, Abe H, Bergtholdt M, Ecanow J, Schmidt R, Newstead G. Multi-modality morphological correlation of axillary lymph nodes. Int J Comput Assist Radiol Surg. 2010; 5(4):343-50.
  • 5. Reintgen D, Giuliano R, Cox CE. Sentinel node biopsy in breast cancer: an overview. Breast J. 2000;6(5):299-305 . 6. Ahn JH, Son EJ, Kim JA, et al. The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. Acta Radiol. 2010;51(8):859-65.
  • 7. Borqstein PJ, Pijpers R, Comans EF, van Diest PJ, Boom RP, Meijer S. Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg. 1998;186(3):275-83.
  • 8. Chaqpar AB, Martin RC, Scoqqins CR, et al. Factors predicting failure to identify a sentinel lymph node in breast cancer. Surgery. 2005;138(1):56-63.
  • 9. Baruah BP, Goyal A, Young P, Douglas-Jones AG, Mansel RE. Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer. Br J Surg. 2010;97(5):680-3.
  • 10. Lumachi F, Ferretti G, Povolato M, et al. Usefulness of 99m-Tc-sestamibi scintimammography in suspected breast cancer and in axillary lymph node metastases detection. Eur J Surg Oncol. 2001;27(3):256-9.
  • 11. Uematsu T, Sano M, Homma K. In vitro high-resolution helical CT of small axillary lymph nodes in patients with breast cancer: correlation of CT and histology. AJR Am J Roentgenol. 2001;176(4):1069-74.
  • 12. Murray AD, Staff RT, Redpath TW, et al. Dynamic contrast enhanced MRI of the axilla in women with breast cancer: comparison with pathology of excised nodes. Br J Radiol. 2002;75(891):220-8.
  • 13. Wahl RL. Current status of PET in breast cancer imaging, staging, and therapy. Semin Roentgenol. 2001;36(3):250-60.
  • 14. Yoshimura G, Sakurai T, Oura S, et al. Evaluation of axillary lymph node status in breast cancer with MRI. Breast Cancer. 1999;6(3):249-58.
  • 15. Sachelarie I, Grossbard ML, Chadha M, Feldman S, Ghesani M, Blum RH. Primary systemic therapy of breast cancer. Oncologist. 2006;11(6):574-89.
  • 16. Harada T, Tanigawa N, Matsuki M, Nohara T, Narabayashi I. Evaluation of lymph node metastases of breast cancer using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. Eur J Radiol. 2007;63(4):401-7.
  • 17. Michel SC, Keller TM, Frohlich JM, et al. Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement. Radiology. 2002;225(2):527-36.
  • 18. Stets C, Brandt S, Wallis F, et al. Axillary lymph node metastases: a statistical analysis of various parameters in MRI with USPIO. J Magn Reson Imaging. 2002;16(1):60-8.
  • 19. Dong H, Li Y, Yu K, Li H. Comparison of image quality and application values on different field-of-view diffusion-weighted imaging of breast cancer. Acta Radiol. 2016;57(1):19-24.
  • 20. Tamura T, Murakami S, Naito K, Yamada T, Fujimoto T, Kikkawa T. Investigation of the optimal b-value to detect breast tumors with diffusion weighted imaging by 1.5-T MRI. Cancer Imaging. 2014;14:11.
  • 21. Çabuk G, Nass Duce M, Özgür A, Apaydın FD, Polat A, Orekici G. The diagnostic value of diffusion-weighted imaging and the apparent diffusion coefficient values in the differentiation of benign and malignant breast lesions. J Med Imaging Radiat Oncol. 2015;59(2):141-8.
  • 22. Nakai G, Matsuki M, Harada T, et al. Evaluation of axillary lymph nodes by diffusion-weighted MRI using ultrasmall superparamagnetic iron oxide in patients with breast cancer: Initial clinical experience. J Magn Reson Imaging. 2011;34(3):557-62. 23. Bernd H, De Kerviler E, Gaillard S, Bonnemain B. Safety and tolerability of ultrasmall superparamagnetic iron oxide contrast agent: comprehensive analysis of a clinical development program. Invest Radiol. 2009;44(6):336-42.
  • 24. Motomura K, Ishitobi M, Komoike Y, et al. SPIO-enhanced magnetic resonance imaging for the detection of metastases in sentinel nodes localized by computed tomography lymphography in patients with breast cancer. Ann Surg Oncol. 2011;18(12):3422-9. 25. Iima M, Le Bihan D, Okumura R, et al. Apparent diffusion coefficient as an MR imaging biomarker of low-risk ductal carcinoma in situ: a pilot study. Radiology. 2011;260(2):364-72.
  • 26. Scaranelo AM, Eiada R, Jacks LM, Kulkarni SR, Crystal P. Accuracy of Unenhanced MR Imaging in the Detection of Axillary Lymph Node Metastasis: Study of Reproducibility and Reliability. Radiology. 2012;262(2):425-34.
  • 27. Luciani A, Dao TH, Lapeyre M, et al. Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: preliminary results. AJR Am J Roentgenol. 2004;182(4):1059-67.
  • 28. Baltzer PA, Dietzel M, Burmeister HP, et al. Application of MR mammography beyond local staging: is there a potential to accurately assess axillary lymph nodes? evaluation of an extended protocol in an initial prospective study. AJR Am J Roentgenol. 2011;196(5):641-7. 29. Kvistad KA, Rydland J, Smethurst HB, Lundgren S, Fjosne HE, Haraldseth O. Axillary lymph node metastases in breast cancer: preoperative detection with dynamic contrast-enhanced MRI. Eur Radiol. 2000;10(9):1464-71.
  • 30. Mortellaro VE, Marshall J, Singer L, et al. Magnetic resonance imaging for axillary staging in patients with breast cancer. J Magn Reson Imaging. 2009;30(2):309-12.
  • 31. Koelliker SL, Chung MA, Mainiero MB, Steinhoff MM, Cady B. Axillary lymph nodes: US-guided fine-needle aspiration for initial staging of breast cancer-correlation with primary tumor size. Radiology. 2008;246(1):81-9.
  • 32. Luciani A, Dao TH, Lapeyre M, et al. Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: preliminary results. AJR Am J Roentgenol. 2004;182(4):1059-67.
  • 33. Vassallo P, Wernecke K, Roos N, Peters PE. Differentiation of benign from malignant superficial lymphadenopathy: the role of high-resolution US. Radiology. 1992;183(1):215-20.
  • 34. Yamaguchi K, Schacht D, Nakazono T, Irie H, Abe H. Diffusion weighted images of metastatic as compared with nonmetastatic axillary lymph nodes in patients with newly diagnosed breast cancer. J Magn Reson Imaging. 2015;42(3):771-8.
  • 35. Scaranelo AM, Eiada R, Jacks LM, Kulkarni SR, Crystal P. Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability. Radiology. 2012;262(2):425-34.
  • 36. Fornasa F, Nesoti MV, Bovo C, Bonavina MG. Diffusion-weighted magnetic resonance imaging in the characterization of axillary lymph nodes in patients with breast cancer. J Magn Reson Imaging. 2012;36(4):858-64.
  • 37. Kim EJ, Kim SH, Kang BJ, Choi BG, Song BJ, Choi JJ. Diagnostic value of breast MRI for predicting metastatic axillary lymph nodes in breast cancer patients: diffusion-weighted MRI and conventional MRI. Magn Reson Imaging. 2014;32(10):1230-6.
  • 38. Miami L, Masako K. Ryosuke O, Kaori T. Detection of axillary lymph node metastasis with diffusion-weighted MR imaging. Clin Imaging. 2014;38(5):633-6.
  • 39. Schipper RJ, Paiman ML, Beets-Tan RGH, et al. Diagnostic Performance of Dedicated Axillary T2 and Diffusion-weighted MR Imaging for Nodal Staging in Breast Cancer. Radiology. 2015;275(2):345-55.
  • 40. He N, Xie C, Wei W, Pan C, Wang W, Lv N, Wu P. A new, preoperative, MRI-based scoring system for diagnosing malignant axillary lymph nodes in women evaluated for breast cancer. Eur J Radiol. 2012;81(10):2602-12.
  • 41. Kamitani T, Hatakenaka M, Yabuuchi H, Matsuo Y, Fujita N, Jinnouchi M, Nagao M. Detection of axillary node metastasis using diffusion-weighted MRI in breast cancer. Clin Imaging. 2013;37(1):56-61.
  • 42. Giuliano AE, Hunt KK, Ballman KV, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011;305(6):569-75.

Aksiller Lenf Nodu ADC Değerlerinin, Yüksek Rezolüsyonlu MR ile Metastatik Lenf Nodu Tespitinde Kullanımı

Yıl 2017, Cilt: 4 Sayı: 2, 17 - 23, 01.08.2017

Öz

Yüksek rezolüsyonlu MR ile ölçülen aksiller lenf
nodu ADC değerlerinin klinik etkinliğinin araştırılması. İnvaziv meme kanserli
18 kadına yüzeyel koiller ile aksiller MR çekimi yapıldı. İki radyolog
belirlenmiş morfolojik kriterlere göre malignite açısından en şüpheli aksiller
lenf nodunu konsensus ile belirleyerek en şüpheli lenf nodunda ADC ölçümü
yaptılar. Patolojik sonuçlar referans kabul edilerek ADC ölçümlerinin
metastatik-reaktif lenf nodu ayrımında tanısal etkinliğini belirlemede gerekli
istatistik değerlendimeler yapıldı. Histopatolojik bulgular 18 hastanın 11’inde
aksiller lenf nodu metastazı saptadı. Metastatik lenf nodlarının ADC değerleri
olmayanlardan daha düşüktü (p=0.006, Mann Whitney U testi). ADC değerli olarak
0.967x10-3 mm2/s değeri eşik değer olarak kabul
edildiğinde istatistiksel olarak duyarlılık, özgüllük, doğruluk, pozitif
prediktif ve negatif prediktif değer sırasıyla 85.7, 100.0, 94.4, 91.7, 100.0
olarak belirlendi. Eğer bizim bu konudaki ilk bulgularımız daha geniş seriler
ile desteklenirse yüksek rezolüsyonlu MR ile ölçülen aksiller lenf nodu ADC
değerleri gelecekte sentinel lenf nodu biyopsisine iyi bir alternatif tarama
metodu olabilir.

Kaynakça

  • 1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2009;59(4):225-49.
  • 2. Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin. 2006;56(1):37-47.
  • 3. Crippa F, Gerali A, Alessi A, Agresti R, Bombardieri E. FDG-PET for axillary lymph node staging in primary breast cancer. Eur J Nucl Med Mol Imaging. 2004;31(Suppl 1):97-102.
  • 4. Meinel LA, Abe H, Bergtholdt M, Ecanow J, Schmidt R, Newstead G. Multi-modality morphological correlation of axillary lymph nodes. Int J Comput Assist Radiol Surg. 2010; 5(4):343-50.
  • 5. Reintgen D, Giuliano R, Cox CE. Sentinel node biopsy in breast cancer: an overview. Breast J. 2000;6(5):299-305 . 6. Ahn JH, Son EJ, Kim JA, et al. The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. Acta Radiol. 2010;51(8):859-65.
  • 7. Borqstein PJ, Pijpers R, Comans EF, van Diest PJ, Boom RP, Meijer S. Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg. 1998;186(3):275-83.
  • 8. Chaqpar AB, Martin RC, Scoqqins CR, et al. Factors predicting failure to identify a sentinel lymph node in breast cancer. Surgery. 2005;138(1):56-63.
  • 9. Baruah BP, Goyal A, Young P, Douglas-Jones AG, Mansel RE. Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer. Br J Surg. 2010;97(5):680-3.
  • 10. Lumachi F, Ferretti G, Povolato M, et al. Usefulness of 99m-Tc-sestamibi scintimammography in suspected breast cancer and in axillary lymph node metastases detection. Eur J Surg Oncol. 2001;27(3):256-9.
  • 11. Uematsu T, Sano M, Homma K. In vitro high-resolution helical CT of small axillary lymph nodes in patients with breast cancer: correlation of CT and histology. AJR Am J Roentgenol. 2001;176(4):1069-74.
  • 12. Murray AD, Staff RT, Redpath TW, et al. Dynamic contrast enhanced MRI of the axilla in women with breast cancer: comparison with pathology of excised nodes. Br J Radiol. 2002;75(891):220-8.
  • 13. Wahl RL. Current status of PET in breast cancer imaging, staging, and therapy. Semin Roentgenol. 2001;36(3):250-60.
  • 14. Yoshimura G, Sakurai T, Oura S, et al. Evaluation of axillary lymph node status in breast cancer with MRI. Breast Cancer. 1999;6(3):249-58.
  • 15. Sachelarie I, Grossbard ML, Chadha M, Feldman S, Ghesani M, Blum RH. Primary systemic therapy of breast cancer. Oncologist. 2006;11(6):574-89.
  • 16. Harada T, Tanigawa N, Matsuki M, Nohara T, Narabayashi I. Evaluation of lymph node metastases of breast cancer using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. Eur J Radiol. 2007;63(4):401-7.
  • 17. Michel SC, Keller TM, Frohlich JM, et al. Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement. Radiology. 2002;225(2):527-36.
  • 18. Stets C, Brandt S, Wallis F, et al. Axillary lymph node metastases: a statistical analysis of various parameters in MRI with USPIO. J Magn Reson Imaging. 2002;16(1):60-8.
  • 19. Dong H, Li Y, Yu K, Li H. Comparison of image quality and application values on different field-of-view diffusion-weighted imaging of breast cancer. Acta Radiol. 2016;57(1):19-24.
  • 20. Tamura T, Murakami S, Naito K, Yamada T, Fujimoto T, Kikkawa T. Investigation of the optimal b-value to detect breast tumors with diffusion weighted imaging by 1.5-T MRI. Cancer Imaging. 2014;14:11.
  • 21. Çabuk G, Nass Duce M, Özgür A, Apaydın FD, Polat A, Orekici G. The diagnostic value of diffusion-weighted imaging and the apparent diffusion coefficient values in the differentiation of benign and malignant breast lesions. J Med Imaging Radiat Oncol. 2015;59(2):141-8.
  • 22. Nakai G, Matsuki M, Harada T, et al. Evaluation of axillary lymph nodes by diffusion-weighted MRI using ultrasmall superparamagnetic iron oxide in patients with breast cancer: Initial clinical experience. J Magn Reson Imaging. 2011;34(3):557-62. 23. Bernd H, De Kerviler E, Gaillard S, Bonnemain B. Safety and tolerability of ultrasmall superparamagnetic iron oxide contrast agent: comprehensive analysis of a clinical development program. Invest Radiol. 2009;44(6):336-42.
  • 24. Motomura K, Ishitobi M, Komoike Y, et al. SPIO-enhanced magnetic resonance imaging for the detection of metastases in sentinel nodes localized by computed tomography lymphography in patients with breast cancer. Ann Surg Oncol. 2011;18(12):3422-9. 25. Iima M, Le Bihan D, Okumura R, et al. Apparent diffusion coefficient as an MR imaging biomarker of low-risk ductal carcinoma in situ: a pilot study. Radiology. 2011;260(2):364-72.
  • 26. Scaranelo AM, Eiada R, Jacks LM, Kulkarni SR, Crystal P. Accuracy of Unenhanced MR Imaging in the Detection of Axillary Lymph Node Metastasis: Study of Reproducibility and Reliability. Radiology. 2012;262(2):425-34.
  • 27. Luciani A, Dao TH, Lapeyre M, et al. Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: preliminary results. AJR Am J Roentgenol. 2004;182(4):1059-67.
  • 28. Baltzer PA, Dietzel M, Burmeister HP, et al. Application of MR mammography beyond local staging: is there a potential to accurately assess axillary lymph nodes? evaluation of an extended protocol in an initial prospective study. AJR Am J Roentgenol. 2011;196(5):641-7. 29. Kvistad KA, Rydland J, Smethurst HB, Lundgren S, Fjosne HE, Haraldseth O. Axillary lymph node metastases in breast cancer: preoperative detection with dynamic contrast-enhanced MRI. Eur Radiol. 2000;10(9):1464-71.
  • 30. Mortellaro VE, Marshall J, Singer L, et al. Magnetic resonance imaging for axillary staging in patients with breast cancer. J Magn Reson Imaging. 2009;30(2):309-12.
  • 31. Koelliker SL, Chung MA, Mainiero MB, Steinhoff MM, Cady B. Axillary lymph nodes: US-guided fine-needle aspiration for initial staging of breast cancer-correlation with primary tumor size. Radiology. 2008;246(1):81-9.
  • 32. Luciani A, Dao TH, Lapeyre M, et al. Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: preliminary results. AJR Am J Roentgenol. 2004;182(4):1059-67.
  • 33. Vassallo P, Wernecke K, Roos N, Peters PE. Differentiation of benign from malignant superficial lymphadenopathy: the role of high-resolution US. Radiology. 1992;183(1):215-20.
  • 34. Yamaguchi K, Schacht D, Nakazono T, Irie H, Abe H. Diffusion weighted images of metastatic as compared with nonmetastatic axillary lymph nodes in patients with newly diagnosed breast cancer. J Magn Reson Imaging. 2015;42(3):771-8.
  • 35. Scaranelo AM, Eiada R, Jacks LM, Kulkarni SR, Crystal P. Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability. Radiology. 2012;262(2):425-34.
  • 36. Fornasa F, Nesoti MV, Bovo C, Bonavina MG. Diffusion-weighted magnetic resonance imaging in the characterization of axillary lymph nodes in patients with breast cancer. J Magn Reson Imaging. 2012;36(4):858-64.
  • 37. Kim EJ, Kim SH, Kang BJ, Choi BG, Song BJ, Choi JJ. Diagnostic value of breast MRI for predicting metastatic axillary lymph nodes in breast cancer patients: diffusion-weighted MRI and conventional MRI. Magn Reson Imaging. 2014;32(10):1230-6.
  • 38. Miami L, Masako K. Ryosuke O, Kaori T. Detection of axillary lymph node metastasis with diffusion-weighted MR imaging. Clin Imaging. 2014;38(5):633-6.
  • 39. Schipper RJ, Paiman ML, Beets-Tan RGH, et al. Diagnostic Performance of Dedicated Axillary T2 and Diffusion-weighted MR Imaging for Nodal Staging in Breast Cancer. Radiology. 2015;275(2):345-55.
  • 40. He N, Xie C, Wei W, Pan C, Wang W, Lv N, Wu P. A new, preoperative, MRI-based scoring system for diagnosing malignant axillary lymph nodes in women evaluated for breast cancer. Eur J Radiol. 2012;81(10):2602-12.
  • 41. Kamitani T, Hatakenaka M, Yabuuchi H, Matsuo Y, Fujita N, Jinnouchi M, Nagao M. Detection of axillary node metastasis using diffusion-weighted MRI in breast cancer. Clin Imaging. 2013;37(1):56-61.
  • 42. Giuliano AE, Hunt KK, Ballman KV, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011;305(6):569-75.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Turan Ilıca Bu kişi benim

Cem Oren Bu kişi benim

Nurcan Ercıktı Bu kişi benim

Brian Goldner Bu kişi benim

İnanç Guvenc Bu kişi benim

Erkan Ozturk Bu kişi benim

Ali Fuat Cicek Bu kişi benim

Gokhan Osmanoglu Bu kişi benim

Semih Gorgulu Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2017
Gönderilme Tarihi 9 Ocak 2018
Yayımlandığı Sayı Yıl 2017 Cilt: 4 Sayı: 2

Kaynak Göster

APA Ilıca, T., Oren, C., Ercıktı, N., Goldner, B., vd. (2017). A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 4(2), 17-23.
AMA Ilıca T, Oren C, Ercıktı N, Goldner B, Guvenc İ, Ozturk E, Cicek AF, Osmanoglu G, Gorgulu S. A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values. MMJ. Ağustos 2017;4(2):17-23.
Chicago Ilıca, Turan, Cem Oren, Nurcan Ercıktı, Brian Goldner, İnanç Guvenc, Erkan Ozturk, Ali Fuat Cicek, Gokhan Osmanoglu, ve Semih Gorgulu. “A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis With ADC Values”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4, sy. 2 (Ağustos 2017): 17-23.
EndNote Ilıca T, Oren C, Ercıktı N, Goldner B, Guvenc İ, Ozturk E, Cicek AF, Osmanoglu G, Gorgulu S (01 Ağustos 2017) A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4 2 17–23.
IEEE T. Ilıca, C. Oren, N. Ercıktı, B. Goldner, İ. Guvenc, E. Ozturk, A. F. Cicek, G. Osmanoglu, ve S. Gorgulu, “A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values”, MMJ, c. 4, sy. 2, ss. 17–23, 2017.
ISNAD Ilıca, Turan vd. “A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis With ADC Values”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4/2 (Ağustos 2017), 17-23.
JAMA Ilıca T, Oren C, Ercıktı N, Goldner B, Guvenc İ, Ozturk E, Cicek AF, Osmanoglu G, Gorgulu S. A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values. MMJ. 2017;4:17–23.
MLA Ilıca, Turan vd. “A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis With ADC Values”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, c. 4, sy. 2, 2017, ss. 17-23.
Vancouver Ilıca T, Oren C, Ercıktı N, Goldner B, Guvenc İ, Ozturk E, Cicek AF, Osmanoglu G, Gorgulu S. A Targeted High-Resolution Axillary MRI to Detect Axillary Lymph Node Metastasis with ADC Values. MMJ. 2017;4(2):17-23.