A review on ophthalmic delivery systems containing flavonoids for the treatment of eye diseases

Year 2021, Volume: Volume 1 Issue: Issue 1, 1 - 13, 16.10.2021

Meltem Cetin

Abstract

Flavonoids, polyphenolic compounds, have many biological effects, including antioxidant, free-radical scavenging properties, antiviral, antibacterial, anti-inflammation, anti-allergic, and anti-carcinogenic effects, anti-platelet, anti-thrombotic, and vasodilating actions. A decreased antioxidant capacity, oxidative stress, and inflammatory mechanisms in the ocular tissues are considered to have a significant role in the development and progression of ocular diseases. Flavonoids have very beneficial effects on eye health, and also on the treatment of eye diseases due to their antioxidant, anti-inflammatory, and ocular blood flow enhancing properties. Most flavonoids have low bioavailability associated with low water solubility. It is important to develop effective ocular drug delivery systems containing flavonoids for application directly to the eye. This delivery system can increase ocular bioavailability and enable flavonoids to reach the internal structures of the eye more effectively. Furthermore, considering the sensitive nature of flavonoids as antioxidant agents, especially nano-sized formulations have in particular become potential carriers for preserving them and improving their bioavailability and therapeutic efficacy. This review will focus the published studies that have investigated the development of delivery systems containing flavonoids for the treatment of eye diseases. In addition, within the scope of this review, flavonoids, common eye diseases, and the materials used in the preparation of the ophthalmic delivery systems containing flavonoids are briefly mentioned.

Keywords

Eye disease, Flavonoids, Nano-sized formulations, Ophthalmic delivery systems

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