Niğde Tıp Dergisi 3023-7149 Niğde Ömer Halisdemir Üniversitesi Medical Biochemistry - Proteins, Peptides and Proteomics Tıbbi biyokimya - Proteinler, Peptitler ve Proteomik İleri Alzheimer Hastalarında Azalmış Serum VEGF ve TGF-Β1 Seviyeleri; bir ön çalışma Decreased Serum VEGF and TGF-Β1 Levels in Advanced Alzheimer's Patients; a preliminary study https://orcid.org/0000-0002-8767-3798 Kaya Ender UNIVERSITY OF HEALTH SCIENCES, İSTANBUL OKMEYDANI HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PSYCHIATRY https://orcid.org/0000-0003-2615-8474 Ayan Durmuş NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0003-3223-6854 Özmen Esma NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-2010-7230 Bulut Seyyid Mehmet NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0003-3732-2102 Sarı İsmail KIRKLARELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-8968-4044 Erşan Serpil NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ 09 30 2024 2 55 65 08 09 2024 09 11 2024 Copyright © 2024, Niğde Tıp Dergisi 2024 Niğde Tıp Dergisi

Amaç: Bu araştırmada ileri evre Alzheimer hastalığında (AH) VEGF (Vasküler Endotelyal Büyüme Faktörü) ve TGF-β1 (Dönüştürücü Büyüme Faktörü-Beta 1) seviyelerinin incelenmesi amaçlanmıştır.Gereç ve Yöntemler: Çalışma kapsamında toplam 60 katılımcı değerlendirilmiştir. Bunların 30'u hasta grubunu, 30'u ise kontrol grubunu oluşturmaktadır. Hasta ve kontrol grubuna ait serum örneklerinde VEGF ve TGF-β1 düzeyleri (ELISA) yöntemiyle ölçülmüştür.Bulgular: AH grubunda, serum VEGF düzeyleri kontrol grubuna göre istatistiksel olarak anlamlı düzeyde düşük bulunmuştur (1373,66±486,07 ng/L'e karşılık 986,27±261,44 ng/L, p

Aim: This study aimed to investigate Vascular endothelial growth factor (VEGF) and Transforming growth factor beta 1(TGF-β1) levels in advanced Alzheimer's disease (AD).Materials and Methods: A total of 60 participants were evaluated within the scope of the study. 30 of them constituted the patient group and 30 constituted the control group. VEGF and TGF-β1 levels in serum samples of the patient and control groups were measured by Enzyme-Linked Immunosorbent Assay (ELISA).Results: In the AD group, serum VEGF levels were found to be statistically significantly lower than in the control group (1373.66±486.07 ng/L vs. 986.27±261.44 ng/L, p

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