Detecting the Presence of Anti-HLA Antıbodies in Autoimmune Diseases

Year 2024, , 187 - 193, 30.09.2024

Murat Kızılkaya , Hasan Dogan

https://doi.org/10.56766/ntms.1526917

Abstract

Aim: By creating antibodies, the immune system protects the body from foreign antigens. The immune system may occasionally sustain damage that results in a loss of tolerance to its antigens, which triggers the creation of antibodies directed against those antigens. Another challenge in solid organ transplantation is the existence of these anti-HLA antibodies. Our goal was to find out if common autoimmune disorders such type 1 diabetes (T1D), Behçet's disease (BD), and ankylosing spondylitis (AS) result in the development of anti-HLA antibodies.
Materials and Methods: 100 patients with AS, 100 patients with BD, 60 patients with T1D, and 100 healthy people were included in this study. PRA screening tests were performed on serum from blood samples taken from both patients and healthy individuals to look for the presence of anti-HLA antibodies.
Results: Of the AS patients, 5 were positive for PRA class II alone, 7 were positive for both PRA class I and class II, and 1 patient was positive for PRA class I. In BD, 3 patients was positive for both PRA class I and II, 7 patients was positive for PRA class II alone, and 1 patient was positive for PRA class I. In T1D, 1 patient were positive for PRA class I, 3 patients were positive for PRA class II alone, and 2 patients were positive for both.
In summary: When three patient groups were compared with the control group, there was no statistically significant difference in the detection of anti-HLA antibodies between the patient groups and the control group.

Keywords

Ankylosing spondylitis, behçet’s disease, type 1 diabetes, transplantation, PRA

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