Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review

Mahmut Aktğrk; Eda Balkan; Necip Altundaş; Murat Kızılkaya

doi:10.56766/ntms.1852728

Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review

Abstract

Abstract Donor-derived cell-free DNA (dd-cfDNA) refers to DNA fragments originating from the transplanted organ tissue that are detected in the recipient's circulation as products of cellular degradation. In recent years, dd-cfDNA has emerged as a compelling biomarker for immune monitoring and early diagnosis of rejection in solid organ transplantation—particularly in kidney, heart, lung, and liver transplants—due to its potential to provide earlier and more sensitive signals compared to conventional biomarkers. This review aims to address the biological foundations of dd-cfDNA, its measurement methodologies, organ-specific experimental and clinical data, as well as its current limitations and future perspectives.

Keywords

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Details

Primary Language

English

Subjects

Immunology (Other)

Journal Section

Review

Authors

Mahmut Aktğrk
0000-0003-0200-4577
Türkiye

Eda Balkan ^*
0000-0002-7065-8161
Türkiye

Necip Altundaş
0000-0002-5165-638X
Türkiye

Murat Kızılkaya
0009-0001-0567-2813
Türkiye

Publication Date

June 30, 2026

Submission Date

December 31, 2025

Acceptance Date

June 27, 2026

Published in Issue

Year 2026 Volume: 7 Number: 2

DOI

https://doi.org/10.56766/ntms.1852728

IZ

https://izlik.org/JA72DY76UL

Cite

RIS / Bibtex

APA

Aktğrk, M., Balkan, E., Altundaş, N., & Kızılkaya, M. (2026). Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review. New Trends in Medicine Sciences, 7(2), 64-71. https://doi.org/10.56766/ntms.1852728

AMA

1.Aktğrk M, Balkan E, Altundaş N, Kızılkaya M. Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review. New Trend Med Sci. 2026;7(2):64-71. doi:10.56766/ntms.1852728

Chicago

Aktğrk, Mahmut, Eda Balkan, Necip Altundaş, and Murat Kızılkaya. 2026. “Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review”. New Trends in Medicine Sciences 7 (2): 64-71. https://doi.org/10.56766/ntms.1852728.

EndNote

Aktğrk M, Balkan E, Altundaş N, Kızılkaya M (June 1, 2026) Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review. New Trends in Medicine Sciences 7 2 64–71.

IEEE

[1]M. Aktğrk, E. Balkan, N. Altundaş, and M. Kızılkaya, “Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review”, New Trend Med Sci, vol. 7, no. 2, pp. 64–71, June 2026, doi: 10.56766/ntms.1852728.

ISNAD

Aktğrk, Mahmut - Balkan, Eda - Altundaş, Necip - Kızılkaya, Murat. “Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review”. New Trends in Medicine Sciences 7/2 (June 1, 2026): 64-71. https://doi.org/10.56766/ntms.1852728.

JAMA

1.Aktğrk M, Balkan E, Altundaş N, Kızılkaya M. Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review. New Trend Med Sci. 2026;7:64–71.

MLA

Aktğrk, Mahmut, et al. “Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review”. New Trends in Medicine Sciences, vol. 7, no. 2, June 2026, pp. 64-71, doi:10.56766/ntms.1852728.

Vancouver

1.Mahmut Aktğrk, Eda Balkan, Necip Altundaş, Murat Kızılkaya. Donor-Derived Cell-Free DNA in Solid Organ Transplantation: An Evidence-Based Review. New Trend Med Sci. 2026 Jun. 1;7(2):64-71. doi:10.56766/ntms.1852728