The Role of Chlorogenic Acid in Alleviating Intestinal Ischemia/Reperfusion-Induced Lung Injury
Yıl 2020,
Cilt: 1 Sayı: 2, 59 - 64, 30.09.2020
Ayhan Tanyeli
,
Derya Güzel
,
Fazile Nur Ekinci Akdemir
,
Ersen Eraslan
,
Mustafa Can Güler
Öz
Aim: Here, Chlorogenic acid (CA) was examined in intestinal ischemia reperfusion (I/R)-induced lung injury. Material and Methods: 4 experimental rat groups were created (n=8): sham, I/R and CA treatment groups. At the end of the experimental process, rats were immolated and lung tissues were excised. Results: Oxidant parameters increased and antioxidant activity declined in I/R group compared to sham group. CA treatments reversed these parameters. Discussion and Conclusion: Different doses of the CA prevented intestinal I/R-induced lung injury in experimental animals.
Kaynakça
- 1. Tullis MJ, Brown S, Gewertz BL. 1996. Hepatic influence on pulmonary neutrophil sequestration following intestinal ischemia-reperfusion. The Journal of surgical research 66:143-6
- 2. Mallick IH, Yang W, Winslet MC, Seifalian AM. 2004. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Digestive diseases and sciences 49:1359-77
- 3. Stallion A, Kou TD, Latifi SQ, Miller KA, Dahms BB, et al. 2005. Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. Journal of pediatric surgery 40:470-7
- 4. Li Y, Xu B, Xu M, Chen D, Xiong Y, et al. 2017. 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-kappaB signalling. Pharmacological research 119:137-48
- 5. Meszaros AT, Buki T, Fazekas B, Tuboly E, Horvath K, et al. 2017. Inhalation of methane preserves the epithelial barrier during ischemia and reperfusion in the rat small intestine. Surgery 161:1696-709
- 6. Moore FA. 1999. The role of the gastrointestinal tract in postinjury multiple organ failure. American journal of surgery 178:449-53
- 7. Thomas S, Karnik S, Balasubramanian KA. 2002. Surgical manipulation of the small intestine and its effect on the lung. The Journal of surgical research 106:145-56
- 8. Ito K, Ozasa H, Horikawa S. 2005. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic Biol Med 38:369-74
- 9. Aytekin FO, Tekin K, Kabay B, Erdem E, Guney Y, et al. 2005. Antithrombin III attenuates pulmonary tissue injury caused by mesenteric ischemia-reperfusion. Am J Surg 189:161-6
- 10. Ozacmak VH, Sayan H, Igdem AA, Cetin A, Ozacmak ID. 2007. Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats. European journal of pharmacology 562:138-47
- 11. Borges SC, da Silva de Souza AC, Beraldi EJ, Schneider LC, Buttow NC. 2016. Resveratrol promotes myenteric neuroprotection in the ileum of rats after ischemia-reperfusion injury. Life sciences 166:54-9
- 12. Zu G, Guo J, Che N, Zhou T, Zhang X, et al. 2016. Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/beta-catenin pathway. Scientific reports 6:38480
- 13. Carden DL, Granger DN. 2000. Pathophysiology of ischaemia-reperfusion injury. The Journal of pathology 190:255-66
- 14. Tapuria N, Kumar Y, Habib MM, Abu Amara M, Seifalian AM, Davidson BR. 2008. Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review. The Journal of surgical research 150:304-30
- 15. Tao T, Chen F, Bo L, Xie Q, Yi W, et al. 2014. Ginsenoside Rg1 protects mouse liver against ischemia–reperfusion injury through anti-inflammatory and anti-apoptosis properties. journal of surgical research 191:231-8
- 16. Vivo V, Zini I, Cantoni AM, Grandi A, Tognolini M, et al. 2017. Protection by the Eph-Ephrin System Against Mesenteric Ischemia-Reperfusion Injury. Shock (Augusta, Ga.) 48:681-9
- 17. Baysal Z, Cengiz M, Ozgonul A, Cakir M, Celik H, Kocyigit A. 2009. Oxidative status and DNA damage in operating room personnel. Clinical biochemistry 42:189-93
- 18. Eraslan E, Tanyeli A, Polat E, Polat E. 2019. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol 234:4572-81
- 19. Eraslan E, Tanyeli A, Polat E, Yetim Z. 2019. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem 120:17159-66
- 20. Ozturk D, Erdogan DG, Tanyeli A, Çomaklı S, Baylan H, Polat E. 2019. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 44:539
- 21. Tanyeli A, author N, Guler M, Eraslan E, Eki F, et al. 2020. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 9:246
- 22. Dogan C, Halici Z, Topcu A, Cadirci E, Karakus E, et al. 2016. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. Andrologia 48:441-52
- 23. Yang L, Wang N, Zheng G. 2018. Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid beta Aggregation and Reactive Oxygen Species Formation In Vitro. Nanoscale Res Lett 13:303
- 24. Tsang MS, Jiao D, Chan BC, Hon KL, Leung PC, et al. 2016. Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation. Molecules 21:519
- 25. Nabavi SF, Tejada S, Setzer WN, Gortzi O, Sureda A, et al. 2017. Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine. Curr Neuropharmacol 15:471-9
- 26. Heitman E, Ingram DK. 2017. Cognitive and neuroprotective effects of chlorogenic acid. Nutr Neurosci 20:32-9
- 27. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry 95:351-8
- 28. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry 38:1103-11
- 29. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
- 30. Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clinical chemistry 34:497-500
- 31. Eltzschig HK, Eckle T. 2011. Ischemia and reperfusion--from mechanism to translation. Nat Med 17:1391-401
- 32. Guan Y, Worrell RT, Pritts TA, Montrose MH. 2009. Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo. American journal of physiology. Gastrointestinal and liver physiology 297:G187-96
- 33. Vollmar B, Menger MD. 2011. Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbeck's archives of surgery 396:13-29
- 34. Collard CD, Gelman S. 2001. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 94:1133-8
- 35. Weil MH, Becker L, Budinger T, Kern K, Nichol G, et al. 2001. Workshop Executive Summary Report: Post-resuscitative and initial Utility in Life Saving Efforts (PULSE): June 29-30, 2000; Lansdowne Resort and Conference Center; Leesburg, VA. Circulation 103:1182-4
- 36. Grootjans J, Lenaerts K, Buurman WA, Dejong CH, Derikx JP. 2016. Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion. World journal of gastroenterology 22:2760-70
- 37. Schellekens DH, Grootjans J, Dello SA, van Bijnen AA, van Dam RM, et al. 2014. Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model. Journal of clinical gastroenterology 48:253-60
- 38. Teke Z, Sacar M, Yenisey C, Atalay AO, Bicakci T, Erdem E. 2008. Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model. American journal of surgery 195:861-73
- 39. Villar J, Blanco J, Anon JM, Santos-Bouza A, Blanch L, et al. 2011. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive care medicine 37:1932-41
- 40. Gregova K, Cikos S, Bilecova-Rabajdova M, Urban P, Varga J, et al. 2015. Intestinal ischemia-reperfusion injury mediates expression of inflammatory cytokines in rats. General physiology and biophysics 34:95-9
- 41. Abu-Elmagd K, Bond G. 2003. Gut failure and abdominal visceral transplantation. The Proceedings of the Nutrition Society 62:727-37
- 42. Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, et al. 1992. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. The American journal of physiology 262:G669-76
- 43. Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM. 1982. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 82:9-15
- 44. Saugstad OD. 1996. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta paediatrica (Oslo, Norway : 1992) 85:1-4
- 45. Wen SH, Ling YH, Li Y, Li C, Liu JX, et al. 2013. Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase. Surgery 153:555-64
- 46. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. 2014. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological reviews 94:329-54
- 47. Wang G, Yao J, Li Z, Zu G, Feng D, et al. 2016. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling. Antioxidants & redox signaling 24:961-73
- 48. Cerqueira NF, Hussni CA, Yoshida WB. 2005. Pathophysiology of mesenteric ischemia/reperfusion: a review. Acta cirurgica brasileira 20:336-43
- 49. Horton JW, Walker PB. 1993. Oxygen radicals, lipid peroxidation, and permeability changes after intestinal ischemia and reperfusion. Journal of applied physiology (Bethesda, Md. : 1985) 74:1515-20
- 50. Mayer AM, Pittner RA, Lipscomb GE, Spitzer JA. 1993. Effect of in vivo TNF administration on superoxide production and PKC activity of rat alveolar macrophages. The American journal of physiology 264:L43-52
- 51. Bertoni S, Arcaro V, Vivo V, Rapalli A, Tognolini M, et al. 2014. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research 81:17-25
- 52. Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D. 2008. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. International journal of clinical pharmacology and therapeutics 46:295-306
- 53. Tanyeli A, Ekinci Akdemir F, Eraslan E, Guler M, Sebin S, Gülçin I. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 9:166-73
- 54. Topdagi O, Tanyeli A, Akdemir FNE, Eraslan E, Guler MC, Comakli S. 2020. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 242:117217
- 55. Derya Guzel AT. 2018. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 8:410-5
- 56. Derya GÜZEL AT. 2018. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 8:260-5
- 57. Ö TOPDAĞI AT, FNE AKDEMİR, DG ERDOĞAN, MC GÜLER. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 4
- 58. Ayhan Tanyeli FNEA, Ersen Eraslan, Mustafa Can Güler, Saime Özbek Sebin, İlhami Gülçin. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 9:166-73
- 59. Almeida AA, Farah A, Silva DA, Nunan EA, Gloria MB. 2006. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J Agric Food Chem 54:8738-43
- 60. Olthof MR, Hollman PC, Katan MB. 2001. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131:66-71
- 61. Bonita JS, Mandarano M, Shuta D, Vinson J. 2007. Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies. Pharmacol Res 55:187-98
- 62. Zhang J, Chen M, Ju W, Liu S, Xu M, et al. 2010. Liquid chromatograph/tandem mass spectrometry assay for the simultaneous determination of chlorogenic acid and cinnamic acid in plasma and its application to a pharmacokinetic study. J Pharm Biomed Anal 51:685-90
Yıl 2020,
Cilt: 1 Sayı: 2, 59 - 64, 30.09.2020
Ayhan Tanyeli
,
Derya Güzel
,
Fazile Nur Ekinci Akdemir
,
Ersen Eraslan
,
Mustafa Can Güler
Kaynakça
- 1. Tullis MJ, Brown S, Gewertz BL. 1996. Hepatic influence on pulmonary neutrophil sequestration following intestinal ischemia-reperfusion. The Journal of surgical research 66:143-6
- 2. Mallick IH, Yang W, Winslet MC, Seifalian AM. 2004. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Digestive diseases and sciences 49:1359-77
- 3. Stallion A, Kou TD, Latifi SQ, Miller KA, Dahms BB, et al. 2005. Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. Journal of pediatric surgery 40:470-7
- 4. Li Y, Xu B, Xu M, Chen D, Xiong Y, et al. 2017. 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-kappaB signalling. Pharmacological research 119:137-48
- 5. Meszaros AT, Buki T, Fazekas B, Tuboly E, Horvath K, et al. 2017. Inhalation of methane preserves the epithelial barrier during ischemia and reperfusion in the rat small intestine. Surgery 161:1696-709
- 6. Moore FA. 1999. The role of the gastrointestinal tract in postinjury multiple organ failure. American journal of surgery 178:449-53
- 7. Thomas S, Karnik S, Balasubramanian KA. 2002. Surgical manipulation of the small intestine and its effect on the lung. The Journal of surgical research 106:145-56
- 8. Ito K, Ozasa H, Horikawa S. 2005. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic Biol Med 38:369-74
- 9. Aytekin FO, Tekin K, Kabay B, Erdem E, Guney Y, et al. 2005. Antithrombin III attenuates pulmonary tissue injury caused by mesenteric ischemia-reperfusion. Am J Surg 189:161-6
- 10. Ozacmak VH, Sayan H, Igdem AA, Cetin A, Ozacmak ID. 2007. Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats. European journal of pharmacology 562:138-47
- 11. Borges SC, da Silva de Souza AC, Beraldi EJ, Schneider LC, Buttow NC. 2016. Resveratrol promotes myenteric neuroprotection in the ileum of rats after ischemia-reperfusion injury. Life sciences 166:54-9
- 12. Zu G, Guo J, Che N, Zhou T, Zhang X, et al. 2016. Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/beta-catenin pathway. Scientific reports 6:38480
- 13. Carden DL, Granger DN. 2000. Pathophysiology of ischaemia-reperfusion injury. The Journal of pathology 190:255-66
- 14. Tapuria N, Kumar Y, Habib MM, Abu Amara M, Seifalian AM, Davidson BR. 2008. Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury--a review. The Journal of surgical research 150:304-30
- 15. Tao T, Chen F, Bo L, Xie Q, Yi W, et al. 2014. Ginsenoside Rg1 protects mouse liver against ischemia–reperfusion injury through anti-inflammatory and anti-apoptosis properties. journal of surgical research 191:231-8
- 16. Vivo V, Zini I, Cantoni AM, Grandi A, Tognolini M, et al. 2017. Protection by the Eph-Ephrin System Against Mesenteric Ischemia-Reperfusion Injury. Shock (Augusta, Ga.) 48:681-9
- 17. Baysal Z, Cengiz M, Ozgonul A, Cakir M, Celik H, Kocyigit A. 2009. Oxidative status and DNA damage in operating room personnel. Clinical biochemistry 42:189-93
- 18. Eraslan E, Tanyeli A, Polat E, Polat E. 2019. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol 234:4572-81
- 19. Eraslan E, Tanyeli A, Polat E, Yetim Z. 2019. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem 120:17159-66
- 20. Ozturk D, Erdogan DG, Tanyeli A, Çomaklı S, Baylan H, Polat E. 2019. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 44:539
- 21. Tanyeli A, author N, Guler M, Eraslan E, Eki F, et al. 2020. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 9:246
- 22. Dogan C, Halici Z, Topcu A, Cadirci E, Karakus E, et al. 2016. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. Andrologia 48:441-52
- 23. Yang L, Wang N, Zheng G. 2018. Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid beta Aggregation and Reactive Oxygen Species Formation In Vitro. Nanoscale Res Lett 13:303
- 24. Tsang MS, Jiao D, Chan BC, Hon KL, Leung PC, et al. 2016. Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation. Molecules 21:519
- 25. Nabavi SF, Tejada S, Setzer WN, Gortzi O, Sureda A, et al. 2017. Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine. Curr Neuropharmacol 15:471-9
- 26. Heitman E, Ingram DK. 2017. Cognitive and neuroprotective effects of chlorogenic acid. Nutr Neurosci 20:32-9
- 27. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry 95:351-8
- 28. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry 38:1103-11
- 29. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
- 30. Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clinical chemistry 34:497-500
- 31. Eltzschig HK, Eckle T. 2011. Ischemia and reperfusion--from mechanism to translation. Nat Med 17:1391-401
- 32. Guan Y, Worrell RT, Pritts TA, Montrose MH. 2009. Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo. American journal of physiology. Gastrointestinal and liver physiology 297:G187-96
- 33. Vollmar B, Menger MD. 2011. Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbeck's archives of surgery 396:13-29
- 34. Collard CD, Gelman S. 2001. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 94:1133-8
- 35. Weil MH, Becker L, Budinger T, Kern K, Nichol G, et al. 2001. Workshop Executive Summary Report: Post-resuscitative and initial Utility in Life Saving Efforts (PULSE): June 29-30, 2000; Lansdowne Resort and Conference Center; Leesburg, VA. Circulation 103:1182-4
- 36. Grootjans J, Lenaerts K, Buurman WA, Dejong CH, Derikx JP. 2016. Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion. World journal of gastroenterology 22:2760-70
- 37. Schellekens DH, Grootjans J, Dello SA, van Bijnen AA, van Dam RM, et al. 2014. Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model. Journal of clinical gastroenterology 48:253-60
- 38. Teke Z, Sacar M, Yenisey C, Atalay AO, Bicakci T, Erdem E. 2008. Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model. American journal of surgery 195:861-73
- 39. Villar J, Blanco J, Anon JM, Santos-Bouza A, Blanch L, et al. 2011. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive care medicine 37:1932-41
- 40. Gregova K, Cikos S, Bilecova-Rabajdova M, Urban P, Varga J, et al. 2015. Intestinal ischemia-reperfusion injury mediates expression of inflammatory cytokines in rats. General physiology and biophysics 34:95-9
- 41. Abu-Elmagd K, Bond G. 2003. Gut failure and abdominal visceral transplantation. The Proceedings of the Nutrition Society 62:727-37
- 42. Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, et al. 1992. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. The American journal of physiology 262:G669-76
- 43. Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM. 1982. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 82:9-15
- 44. Saugstad OD. 1996. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta paediatrica (Oslo, Norway : 1992) 85:1-4
- 45. Wen SH, Ling YH, Li Y, Li C, Liu JX, et al. 2013. Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase. Surgery 153:555-64
- 46. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. 2014. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological reviews 94:329-54
- 47. Wang G, Yao J, Li Z, Zu G, Feng D, et al. 2016. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling. Antioxidants & redox signaling 24:961-73
- 48. Cerqueira NF, Hussni CA, Yoshida WB. 2005. Pathophysiology of mesenteric ischemia/reperfusion: a review. Acta cirurgica brasileira 20:336-43
- 49. Horton JW, Walker PB. 1993. Oxygen radicals, lipid peroxidation, and permeability changes after intestinal ischemia and reperfusion. Journal of applied physiology (Bethesda, Md. : 1985) 74:1515-20
- 50. Mayer AM, Pittner RA, Lipscomb GE, Spitzer JA. 1993. Effect of in vivo TNF administration on superoxide production and PKC activity of rat alveolar macrophages. The American journal of physiology 264:L43-52
- 51. Bertoni S, Arcaro V, Vivo V, Rapalli A, Tognolini M, et al. 2014. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research 81:17-25
- 52. Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D. 2008. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. International journal of clinical pharmacology and therapeutics 46:295-306
- 53. Tanyeli A, Ekinci Akdemir F, Eraslan E, Guler M, Sebin S, Gülçin I. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 9:166-73
- 54. Topdagi O, Tanyeli A, Akdemir FNE, Eraslan E, Guler MC, Comakli S. 2020. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 242:117217
- 55. Derya Guzel AT. 2018. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 8:410-5
- 56. Derya GÜZEL AT. 2018. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 8:260-5
- 57. Ö TOPDAĞI AT, FNE AKDEMİR, DG ERDOĞAN, MC GÜLER. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 4
- 58. Ayhan Tanyeli FNEA, Ersen Eraslan, Mustafa Can Güler, Saime Özbek Sebin, İlhami Gülçin. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 9:166-73
- 59. Almeida AA, Farah A, Silva DA, Nunan EA, Gloria MB. 2006. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J Agric Food Chem 54:8738-43
- 60. Olthof MR, Hollman PC, Katan MB. 2001. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131:66-71
- 61. Bonita JS, Mandarano M, Shuta D, Vinson J. 2007. Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies. Pharmacol Res 55:187-98
- 62. Zhang J, Chen M, Ju W, Liu S, Xu M, et al. 2010. Liquid chromatograph/tandem mass spectrometry assay for the simultaneous determination of chlorogenic acid and cinnamic acid in plasma and its application to a pharmacokinetic study. J Pharm Biomed Anal 51:685-90