In the current work, the effects of curcumin on testicular tissues in Ehrlich Ascites Tumor (EAT) model developed in Balb/C mice.
EAT cells (1x106) received from stock of animals were injected intraperitoneally to animals. 25mg/kg and 50mg/kg of curcumin was administered intraperitoneally. Testicular tissues obtained after all the experiment were evaluated for histopathological and biochemical parameters.
Histopathological results showed that 50 mg/kg curcumin group had less EAT cells around testicular tissues than tumor control group. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH), oxide glutathione (GSSG), total antioxidant status (TAS), total oxidant status (TOS), interleukin-1beta (IL-1β), interleukin-6, interleukin-17, tumor necrosis factor-alfa (TNF-α) levels were measured in testis tissues. Oxidative stress index (OSI) and GSH/GSSG ratio were calculated. Findings clearly suggested that antioxidant parameters (except CAT and GPx) had higher value in animal models treated with 25 and 50 mg curcumin groups associated to tumor control group. There was a statistically noteworthy variance between the groups in all parameters.
Antitumor effect of curcumin on ascites tumor cells produced by EAT cells evidenced with histopathological while antioxidant and anti-inflammatory biochemical parameters evidenced with biochemical parameters.