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A Comparison of Vitamin D Levels and Also Monocyte/HDL Cholesterol Ratios of Adults with Different Body Mass Index who Consulted Diet Outpatient Clinic.

Yıl 2021, Cilt: 2 Sayı: 2, 116 - 122, 15.09.2021

Öz

 Aim
Monocyte / HDL-Cholesterol ratio is an inflammatory marker. In this study, while the body mass index categories of the individuals who consulted diet outpatient clinic were grouped to underweighed, healthy, overweighed and obese; obesity was divided into 4 subgroups and it was aimed to see if there was a difference in vitamin D levels and also monocyte / HDL-Cholesterol ratio among all groups.
Materials and Methods
The medical records of people who attended to the outpatient nutrition clinic for the first time at the XXXX Hospital within the month of April were reviewed retrospectively. The attendees were grouped according to their body mass index. Monocyte counts, HDL-Cholesterol and vitamin D levels were found from the records. Monocyte / HDL-Cholesterol ratio was calculated for each person. Descriptive analyzes, Kolmogorov-Smirnov, Shapiro-Wilk normality test, Mann-Whitney U and Kruskal Wallis H tests were used. The data were analyzed using SPSS 25.0. Approval of the Regional Clinical Research Ethics Committee was obtained (23/07/2019, 1364). Informed consent form was taken from the patients.
Results
The HDL-Cholesterol means of healthy group were significantly higher than the groups with higher body mass index (p < 0.05). Monocyte means of men and HDL-Cholesterol means of women were significantly higher than the other gender (p < 0.05). There was no statistically significant difference in monocyte / HDL-Cholesterol ratio means between body mass index groups (p > 0.05). Vitamin D means of morbid obese and super obese people were significantly lower than the means of normal and overweight groups (p < 0.05).
Conclusion
In this study, monocyte / HDL-Cholesterol ratio doesn’t seem as an inflammatory marker for obesity. It should be keep in mind that vitamin D may be low in obese people.

Destekleyen Kurum

NA

Proje Numarası

NA

Teşekkür

NA

Kaynakça

  • Satman I, Omer B, Tutuncu Y et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28:169–80.
  • Heilbronn L, Campbell L. Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity. Curr Pharm Des 2008;14:1225–30.
  • Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity & inflammation: The linking mechanism & the complications. Arch Med Sci 2017;13:851–63.
  • Lundström P, Caidahl K, Eriksson MJ et al. Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers. J Nutr Metab 2019;1840374.
  • Azzam EZ, Ata MN, Younan DN, Salem TM, Abdul-Aziz AA. DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism. J Clin Transl Endocrinol 2019;17:100197.
  • Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72:690–3.
  • Rock CL, Emond JA, Flatt SW, Heath DD, Karanja N, Pakiz B, Sherwood NE, Thomson CA. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity 2012;20:2296–2301.
  • Health Implications of Obesity. NIH Consens Statement Online 1985 Feb 11-13 [cited year month day]; 5(9):1-7.
  • Türkiye Endokrinoloji ve Metabolizma Derneği. Obezite Tanı ve Tedavi Kılavuzu. Ankara: BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti; 2019. p.11.
  • Türkiye Endokrinoloji ve Metabolizma Derneği. Metabolik Sendrom Kılavuzu. Ankara: BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti; 2009. p.8.
  • Chen Y, Zhang XP, Yuan J et al. Association of body mass index and age with incident diabetes in Chinese adults: A population-based cohort study. BMJ Open 2018;021768.
  • Laurson KR, McCann DA, Senchina DS. Age, sex, and ethnicity may modify the influence of obesity on inflammation. J Investig Med 2011;59:27–31.
  • Kim DJ, Noh JH, Lee BW et al. The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J Korean Med Sci 2008;23:193–8.
  • Hilgendorf I, Swirski F, Robbins C. Monocyte fate in atherosclerosis. Arter Thromb Vasc Biol 2015;35:272–9.
  • Starr JM, Deary IJ. Sex differences in blood cell counts in the Lothian Birth Cohort 1921 between 79 and 87 years. Maturitas 2011;69:373–6.
  • Bain BJ. Ethnic and sex differences in the total and differential white cell count and platelet count. J Clin Pathol 1996;49:664–6.
  • Niederauer CM, Binkley TL, Specker BL. Effect of truncal adiposity on plasma lipid and lipoprotein concentrations. J Nutr Heal Aging 2006;10:154–60.
  • Ghazizadeh H, Mirinezhad S, Asadi Z et al. Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population. J Clin Lab Anal 2019;13:e23160.
  • Legato MJ. Dyslipidemia, gender, and the role of high-density lipoprotein cholesterol: implications for therapy. Am J Cardiol 2000;86:15L–18L.
  • Vahit D, Akboga M, Samet Y. Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome. Biomark Med 2017;11:535–40.
  • Karatas A, Turkmen E, Erdem E, Al E. Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy. Biomarkers Med 2018;12:953–9.
  • Usta A, Avci E, Bulbul CB, Kadi H, Adali E. The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome. Reprod Biol Endocrinol 2018;16:34.
  • Nalbant A, Konuk S. Obezite ile D vitamini, C-reaktif protein, hemogram parametreleri ve kan grupları arasındaki ilişki. Ortadoğu Tıp Derg 2017;10:20–5.
  • Wamberg L, Christiansen T, Paulsen SK et al. Expression of vitamin D-metabolizing enzymes in human adipose tissue - The effect of obesity and diet-induced weight loss. Int J Obes 2013;37:651–7.
  • Vimaleswaran KS, Berry DJ, Lu C et al. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Med 2013;10:e1001383.
Yıl 2021, Cilt: 2 Sayı: 2, 116 - 122, 15.09.2021

Öz

Proje Numarası

NA

Kaynakça

  • Satman I, Omer B, Tutuncu Y et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28:169–80.
  • Heilbronn L, Campbell L. Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity. Curr Pharm Des 2008;14:1225–30.
  • Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity & inflammation: The linking mechanism & the complications. Arch Med Sci 2017;13:851–63.
  • Lundström P, Caidahl K, Eriksson MJ et al. Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers. J Nutr Metab 2019;1840374.
  • Azzam EZ, Ata MN, Younan DN, Salem TM, Abdul-Aziz AA. DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism. J Clin Transl Endocrinol 2019;17:100197.
  • Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72:690–3.
  • Rock CL, Emond JA, Flatt SW, Heath DD, Karanja N, Pakiz B, Sherwood NE, Thomson CA. Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women. Obesity 2012;20:2296–2301.
  • Health Implications of Obesity. NIH Consens Statement Online 1985 Feb 11-13 [cited year month day]; 5(9):1-7.
  • Türkiye Endokrinoloji ve Metabolizma Derneği. Obezite Tanı ve Tedavi Kılavuzu. Ankara: BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti; 2019. p.11.
  • Türkiye Endokrinoloji ve Metabolizma Derneği. Metabolik Sendrom Kılavuzu. Ankara: BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti; 2009. p.8.
  • Chen Y, Zhang XP, Yuan J et al. Association of body mass index and age with incident diabetes in Chinese adults: A population-based cohort study. BMJ Open 2018;021768.
  • Laurson KR, McCann DA, Senchina DS. Age, sex, and ethnicity may modify the influence of obesity on inflammation. J Investig Med 2011;59:27–31.
  • Kim DJ, Noh JH, Lee BW et al. The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J Korean Med Sci 2008;23:193–8.
  • Hilgendorf I, Swirski F, Robbins C. Monocyte fate in atherosclerosis. Arter Thromb Vasc Biol 2015;35:272–9.
  • Starr JM, Deary IJ. Sex differences in blood cell counts in the Lothian Birth Cohort 1921 between 79 and 87 years. Maturitas 2011;69:373–6.
  • Bain BJ. Ethnic and sex differences in the total and differential white cell count and platelet count. J Clin Pathol 1996;49:664–6.
  • Niederauer CM, Binkley TL, Specker BL. Effect of truncal adiposity on plasma lipid and lipoprotein concentrations. J Nutr Heal Aging 2006;10:154–60.
  • Ghazizadeh H, Mirinezhad S, Asadi Z et al. Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population. J Clin Lab Anal 2019;13:e23160.
  • Legato MJ. Dyslipidemia, gender, and the role of high-density lipoprotein cholesterol: implications for therapy. Am J Cardiol 2000;86:15L–18L.
  • Vahit D, Akboga M, Samet Y. Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome. Biomark Med 2017;11:535–40.
  • Karatas A, Turkmen E, Erdem E, Al E. Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy. Biomarkers Med 2018;12:953–9.
  • Usta A, Avci E, Bulbul CB, Kadi H, Adali E. The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome. Reprod Biol Endocrinol 2018;16:34.
  • Nalbant A, Konuk S. Obezite ile D vitamini, C-reaktif protein, hemogram parametreleri ve kan grupları arasındaki ilişki. Ortadoğu Tıp Derg 2017;10:20–5.
  • Wamberg L, Christiansen T, Paulsen SK et al. Expression of vitamin D-metabolizing enzymes in human adipose tissue - The effect of obesity and diet-induced weight loss. Int J Obes 2013;37:651–7.
  • Vimaleswaran KS, Berry DJ, Lu C et al. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Med 2013;10:e1001383.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Research Articles
Yazarlar

Aynur Arslan 0000-0001-5968-5823

H. Nur Atac 0000-0002-5110-9829

Proje Numarası NA
Yayımlanma Tarihi 15 Eylül 2021
Gönderilme Tarihi 30 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 2

Kaynak Göster

EndNote Arslan A, Atac HN (01 Eylül 2021) A Comparison of Vitamin D Levels and Also Monocyte/HDL Cholesterol Ratios of Adults with Different Body Mass Index who Consulted Diet Outpatient Clinic. New Trends in Medicine Sciences 2 2 116–122.