Multiple Injections of PRP/Steroid Combination Result in Better Clinical Outcames in Advanced Osteoarthritis: A Prospective Randomized Study

Yıl 2022, Cilt: 3 Sayı: 1, 36 - 42, 15.01.2022

Mehmet Cenk Turgut Muhammet Salih Ayas Erhan Okay Ömer Selim Yıldırım

Öz

Aim: The impact of PRP/steroid combination in advanced osteoarthritis is unclear. Multiple intraarticular injections are thought to sustain better clinical scores. The objective of this prospective study is to evaluate the effect after repeated injections of corticosteroid (CS) and platelet-rich plasma (PRP) treatment compared to single dose PRP/steroid injection in patients affected by advanced osteoarthritis.
Material and Methods: A total of 98 patients affected by clinically and radiographically documented with grade 3 - 4 gonarthrosis according to the Kellgren- Lawrence classification were included in this study. The patients were randomized into 2 study groups. Forty-nine patients (Group 1) received three intra-articular injections of PRP (5mL) and steroid (1 cc – 5 mgr triamcinolone). Forty-nine patients (Group 2) received one intra-articular injection of PRP/steroid (5 mL). In multiple injection group, an unblinded physician performed the injection once a week for three weeks into the affected knee in both groups. All patients were evaluated with the VAS score and the Knee injury and Osteoarthritis Outcome Score (KOOS) subscales before the infiltration, at 2 and 6 months after the first injection.
Results: Two groups are similar concerning demographic variables (age, gender, BMI, stage of arthritis) were in both groups. The combination of intra-articular PRP with steroids resulted in a significantly superior clinical outcome, with sustained lower VAS (p<0.05) and improved KOOS subscales (p<0.05) except for KOOS sporting activity (at 2 months), KOOS quality of life (at 2 and 6 months).
Conclusion: This prospective randomized trial demonstrated that multiple intraarticular injections of PRP/steroid combination are more effective in advanced osteoarthritis when compared to single injection with lower VAS scores and better KOOS scores at 6 months after injection therapy.

Anahtar Kelimeler

Platelet rich plasma, corticosteroid, intraarticular injection, advanced arthritis

Kaynakça

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