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Siyanobakteri Kaynaklı Toksin Tehlikesi

Yıl 2021, Cilt: 16 Sayı: 1, 1 - 17, 21.01.2021

Öz

Siyanobakteri kaynaklı toksin tehlikesi incelenmiştir. Siyanobakteriler Dünya atmosferinin oluşumuna ve azot fiksasyonuna önemli katkıda bulunan canlılar olmakla beraber insan ve hayvanlar için zehirli çeşitli sekonder metabolitler üretebilmektedirler. Yaklaşık 2.5 milyar yıl önce fotosentez yapma yeteneği kazandığı düşünülen siyanobakteriler dünya atmosferinin oksik duruma geçmesinde rol alan en ilkel fotosentetik canlılardır. Alg ve bakteri arası prokaryotik bir form olan siyanobakteriler dünya üzerinde çok çeşitli ve geniş habitatlara yayılmışlardır. Son yıllarda dünya genelindeki su kaynaklarında ortaya çıkan kirlilik sucul ekosistemlerde siyanobakterilerin aşırı üremelerine öncülük etmektedir. Siyanobakterilerin besin girdisinin yüksek olduğu sucul alanlarda aşırı çoğalmaları olgusu “alg patlaması (bloom)” olarak tanımlanmaktadır. Toksik türlerin de dahil olduğu alg patlamaları su kaynaklarının insan faaliyetleri için kullanımını sınırlandırmakta ve içme suyu güvenliğini tehdit etmektedir. Bu derlemede alg patlamaları ile neticelenen süreçteki mekanizmalar ve özellikleri, bazı siyanobakteriler tarafından üretilen siyanotoksinler ve etkileri, zararlı alg patlamalarını tetikleyebilen çevresel dinamikler ve alg patlamalarının henüz gerçekleşmeden önlenmesi veya devam eden alg patlamalarının kontrol altına alınması için uygulanabilecek olası tedbirler tartışılmıştır.

Kaynakça

  • Albay, M., Akçaalan, R., Tüfekçi, H., Metcalf, J.S., Beattie, K.A., and Codd, G.A., (2003). Depth Profiles of Cyanobacterial Hepatotoxins (microcystins) in Three Turkish Freshwater Lakes. Hydrobiologia, 505:89–95.
  • Albay, M., Matthiensen, A., and Codd, G.A., (2005). Occurrence of Toxic Blue-Green Algae in the Kucukcekmece Lagoon (Istanbul, Turkey). Environmental Toxicology, 20(3):277-284.
  • Anneville, O., Domaizon, I., Kerimoglu, O., Rimet, F., and Jacquet, S., (2015). Blue-green Algae in a “Greenhouse Century”? New Insights from Field Data on Climate Change Impacts on Cyanobacteria Abundance. Ecosystems 18:441–458.
  • Antunes, J.T., Leão, P.N., and Vasconcelos, V.M., (2015). Cylindrospermopsis Raciborskii: Review of the Distribution, Phylogeography, and Ecophysiology of a Global Invasive Species. Front. Microbiol. 6:473.
  • Barrington, D.J., Reichwaldt, E.S., and Ghadouani, A., (2013). The Use of Hydrogen Peroxide to Remove Cyanobacteria and Microcystins from Waste Stabilization Ponds and Hypereutrophic Systems. Ecol. Eng. 50:86–94.
  • Berg, U., Neumann, T., Donnert, D., Nüesch, R., and Stüben, D., (2004). Sediment Capping in Eutrophic Lakes: Efficiency of Undisturbed Calcite Barriers to Immobilize Phosphorus. Appl. Geochem. 19:1759–1771.
  • Carmichael, W.W., (2001). Health Effects of Toxin- Producing Cyanobacteria: “The CyanoHABs”. Hum. Ecol. Risk Assess. 7:1393–1407.
  • Chen, L., Chen, J., Zhang, X., and Xie, P., (2016). A Review of Reproductive Toxicity of Microcystins. J. Hazard. Mater. 301:381–399.
  • Chorus, I. and Bartram, J., (‎1999)‎. Toxic Cyanobacteria in Water: a Guide to Their Public Health Consequences, Monitoring and Management/edited by Ingrid Chorus and Jamie Bertram. World Health Organization.
  • Coloma, S. E., Dienstbier, A., Bamfor, D.H., Sivonen, K., Roine, E., Hiltunen, T. (2017). Newly Isolated Nodularia Phage Influences Cyanobacterial Community Dynamics. Environ. Microbiol. 19:273–286.
  • De la Cruz, A.A., Hiskia, A., Kaloudis, T., Chernoff, N., Hill, D., Antoniou, M.G., He, X., Loftin, K., O’Shea, K., and Dionysiou, D., (2013). A Review on Cylindrospermopsin: the Global Occurence, Detection, Toxicity and Degradation of a Potent Cyanotoxin. Environmental Science Processes & Impacts, 15:1979-2003.
  • Durai, P., Batool, M., and Choi, S., (2015). Structure and Effects of Cyanobacterial Lipopolysaccharides. Mar. Drugs, 13:4217–4230.
  • Elliott, J.A., (2010). The Seasonal Sensitivity of Cyanobacteria and Other Phytoplankton to Changes in Flushing Rate and water Temperature. Glob. Chang. Biol. 16:864–876.
  • Evangelista, V., Barsanti, L., Franssanito, A.M., Passarelli, V., and Gualtieri, P., (2008). Algal Toxins: Nature, Occurrence, Effect and Detection (1. Baskı). Springer Netherlands.
  • Fakıoğlu, Ö., Atamanalp, M. and Demir, N., (2011). Baraj Göllerinde Toksik Mavi-Yeşil Algler. Ankara Üniversitesi Çevre Bilimleri Dergisi, 3(2):56-71.
  • Fastner, J., Abella, S., Litt, A., Morabito, G., Vörös, L., Palffy, K., Straile, D., Kümmerlin, R., Matthews, D., Phillips, M.G., and Chorus, I., (2016). Combating Cyanobacterial Proliferation by Avoiding or Treating Inflows with High P Load: Experiences from Eight Case Studies. Aquat. Ecol. 50:367–383.
  • Gerphagnon, M., Macarthur, D.J., Latour, D., Gachon, C.M.M., Van Ogtrop, F., Gleason, F.H., and Sime-Ngando, T., (2015). Microbial Players Involved in the Decline of Filamentous and Colonial Cyanobacterial Blooms with a Focus on Fungal Parasitism. Environ. Microbiol. 17:2573–2587.
  • Gobler, C.J., (2016). The Dual Role of Nitrogen Supply in Controlling the Growth and Toxicity of Cyanobacterial Blooms. Harmful Algae, 54:87–97.
  • Gürbüz, F., Metcalf, J.S., Karahan, A.G., and Codd, G.A., (2009). Analysis of Dissolved Microcystins in Surface Water Samples from Kovada Lake, Turkey. Science of the Total Environment, 407:4038-4046.
  • Hawkins, P.R., Runnegar, M.T., Jackson, A.R., and Falconer, I.R., (1985). Severe Hepatotoxicity Caused by the Tropical Cyanobacterium (blue- green alga) Cylindrospermopsis Raciborskii (Woloszynska) Seenaya and Subba Raju Isolated from a Domestic Water Supply Reservoir. Appl. Environ. Microbiol. 50:1292–1295.
  • Huisman, J., Codd, G.A., Paerl, H.W., Ibelings, B.W., Verspagen, J.M.H., and Visser, P.M., (2018). Cyanobacterial Blooms. Microbiology, 16:471-483.9.
  • Humpage, A.R. and Falconer, I.R., (2003). Oral Toxicity of the Cyanobacterial Toxin Cylindrospermopsin in Male Swiss Albino Mice: Determination of No Observed Adverse Effect Level for Deriving a Drinking Water Guideline Value. Environmental Toxicology, 18(2):94-103.
  • Ibelings, B.W. and Maberly, S.C., (1998). Photoinhibition and The Availability of Inorganic Carbon Restrict Photosynthesis by Surface Blooms of Cyanobacteria. Limnol. Oceanogr. 43:408–419.
  • İspirli, S., (2009). İzmir Tahtalı Baraj Gölü’nün Toksik Siyanobakteri Türleri ve Bazı Mikrosistin Varyantları Yönünden Araştırılması. Doktora Tezi. Ege Üniversitesi Fen Bilimleri Enstitüsü, İzmir, 77 sayfa.
  • Janssen, E., (2019). Cyanobacterial Peptides Beyond Microcystins – A Review on Co-Occurrence, Toxicity and Challenges for Risk Assessment. Water Research. 151:488-499.
  • Ji, X., Verspagen, J.M.H., Stomp, M., and Huisman, J., (2017). Competition Between Cyanobacteria and Green Algae at Low Versus Elevated CO2: Who Will Win, and Why? J. Exp. Bot. 68:3815–3828.
  • Jochimsen, E.M., Carmichael, W.W., An, J., Cardo, D.M., Cookson, S.T., Holmes, C.E.M., Antunes, M.B.C., Filho D.A.M., Lyra, T.M., Barreto, V.S.T., Azevedo, S.M.F.O., and Jarvis, W.R., (1998). Liver Failure and Death After Exposure to Microcystins at A Hemodialysis Center in Brazil. N. Engl. J. Med. 338:873–878.
  • Jöhnk, K.D., (2008). Summer Heatwaves Promote Blooms of Harmful Cyanobacteria. Glob. Chang. Biol. 14:495–512.
  • Kahraman, S.D. and Küplülü, Ö., (2012). Siyanobakteriler ve Toksinleri. Vet Hekim Der. Dergisi. 83(2):36-47.
  • Krienitz, L. Ballot, A., Kotut, K., Wiegand, C., Pütz, S., Metcalf, J.S., Codd, A.G., and Pflugmacher, S., (2003). Contribution of Hot Spring Cyanobacteria to the Mysterious Deaths of Lesser Flamingos at Lake Bogoria, Kenya. FEMS Microbiology Ecology, 43:141-148.
  • Lehman, P.W., (2017). Impacts of the 2014 Severe Drought on the Microcystis Bloom in San Francisco Estuary. Harmful Algae, 63:94–108.
  • Lürling, M. and Faassen, E.J., (2012). Controlling Toxic Cyanobacteria: Effects of Dredging and Phosphorusbinding Clay on Cyanobacteria and Microcystins. Water Res. 46:1447–1459.
  • Matthijs, H.C.P., Jančula, D., Visser, P.M., and Maršálek, B., (2016). Existing and Emerging Cyanocidal Compounds: New Perspectives for Cyanobacterial Bloom Mitigation. Aquat. Ecol. 50:443–460.
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Yıl 2021, Cilt: 16 Sayı: 1, 1 - 17, 21.01.2021

Öz

Kaynakça

  • Albay, M., Akçaalan, R., Tüfekçi, H., Metcalf, J.S., Beattie, K.A., and Codd, G.A., (2003). Depth Profiles of Cyanobacterial Hepatotoxins (microcystins) in Three Turkish Freshwater Lakes. Hydrobiologia, 505:89–95.
  • Albay, M., Matthiensen, A., and Codd, G.A., (2005). Occurrence of Toxic Blue-Green Algae in the Kucukcekmece Lagoon (Istanbul, Turkey). Environmental Toxicology, 20(3):277-284.
  • Anneville, O., Domaizon, I., Kerimoglu, O., Rimet, F., and Jacquet, S., (2015). Blue-green Algae in a “Greenhouse Century”? New Insights from Field Data on Climate Change Impacts on Cyanobacteria Abundance. Ecosystems 18:441–458.
  • Antunes, J.T., Leão, P.N., and Vasconcelos, V.M., (2015). Cylindrospermopsis Raciborskii: Review of the Distribution, Phylogeography, and Ecophysiology of a Global Invasive Species. Front. Microbiol. 6:473.
  • Barrington, D.J., Reichwaldt, E.S., and Ghadouani, A., (2013). The Use of Hydrogen Peroxide to Remove Cyanobacteria and Microcystins from Waste Stabilization Ponds and Hypereutrophic Systems. Ecol. Eng. 50:86–94.
  • Berg, U., Neumann, T., Donnert, D., Nüesch, R., and Stüben, D., (2004). Sediment Capping in Eutrophic Lakes: Efficiency of Undisturbed Calcite Barriers to Immobilize Phosphorus. Appl. Geochem. 19:1759–1771.
  • Carmichael, W.W., (2001). Health Effects of Toxin- Producing Cyanobacteria: “The CyanoHABs”. Hum. Ecol. Risk Assess. 7:1393–1407.
  • Chen, L., Chen, J., Zhang, X., and Xie, P., (2016). A Review of Reproductive Toxicity of Microcystins. J. Hazard. Mater. 301:381–399.
  • Chorus, I. and Bartram, J., (‎1999)‎. Toxic Cyanobacteria in Water: a Guide to Their Public Health Consequences, Monitoring and Management/edited by Ingrid Chorus and Jamie Bertram. World Health Organization.
  • Coloma, S. E., Dienstbier, A., Bamfor, D.H., Sivonen, K., Roine, E., Hiltunen, T. (2017). Newly Isolated Nodularia Phage Influences Cyanobacterial Community Dynamics. Environ. Microbiol. 19:273–286.
  • De la Cruz, A.A., Hiskia, A., Kaloudis, T., Chernoff, N., Hill, D., Antoniou, M.G., He, X., Loftin, K., O’Shea, K., and Dionysiou, D., (2013). A Review on Cylindrospermopsin: the Global Occurence, Detection, Toxicity and Degradation of a Potent Cyanotoxin. Environmental Science Processes & Impacts, 15:1979-2003.
  • Durai, P., Batool, M., and Choi, S., (2015). Structure and Effects of Cyanobacterial Lipopolysaccharides. Mar. Drugs, 13:4217–4230.
  • Elliott, J.A., (2010). The Seasonal Sensitivity of Cyanobacteria and Other Phytoplankton to Changes in Flushing Rate and water Temperature. Glob. Chang. Biol. 16:864–876.
  • Evangelista, V., Barsanti, L., Franssanito, A.M., Passarelli, V., and Gualtieri, P., (2008). Algal Toxins: Nature, Occurrence, Effect and Detection (1. Baskı). Springer Netherlands.
  • Fakıoğlu, Ö., Atamanalp, M. and Demir, N., (2011). Baraj Göllerinde Toksik Mavi-Yeşil Algler. Ankara Üniversitesi Çevre Bilimleri Dergisi, 3(2):56-71.
  • Fastner, J., Abella, S., Litt, A., Morabito, G., Vörös, L., Palffy, K., Straile, D., Kümmerlin, R., Matthews, D., Phillips, M.G., and Chorus, I., (2016). Combating Cyanobacterial Proliferation by Avoiding or Treating Inflows with High P Load: Experiences from Eight Case Studies. Aquat. Ecol. 50:367–383.
  • Gerphagnon, M., Macarthur, D.J., Latour, D., Gachon, C.M.M., Van Ogtrop, F., Gleason, F.H., and Sime-Ngando, T., (2015). Microbial Players Involved in the Decline of Filamentous and Colonial Cyanobacterial Blooms with a Focus on Fungal Parasitism. Environ. Microbiol. 17:2573–2587.
  • Gobler, C.J., (2016). The Dual Role of Nitrogen Supply in Controlling the Growth and Toxicity of Cyanobacterial Blooms. Harmful Algae, 54:87–97.
  • Gürbüz, F., Metcalf, J.S., Karahan, A.G., and Codd, G.A., (2009). Analysis of Dissolved Microcystins in Surface Water Samples from Kovada Lake, Turkey. Science of the Total Environment, 407:4038-4046.
  • Hawkins, P.R., Runnegar, M.T., Jackson, A.R., and Falconer, I.R., (1985). Severe Hepatotoxicity Caused by the Tropical Cyanobacterium (blue- green alga) Cylindrospermopsis Raciborskii (Woloszynska) Seenaya and Subba Raju Isolated from a Domestic Water Supply Reservoir. Appl. Environ. Microbiol. 50:1292–1295.
  • Huisman, J., Codd, G.A., Paerl, H.W., Ibelings, B.W., Verspagen, J.M.H., and Visser, P.M., (2018). Cyanobacterial Blooms. Microbiology, 16:471-483.9.
  • Humpage, A.R. and Falconer, I.R., (2003). Oral Toxicity of the Cyanobacterial Toxin Cylindrospermopsin in Male Swiss Albino Mice: Determination of No Observed Adverse Effect Level for Deriving a Drinking Water Guideline Value. Environmental Toxicology, 18(2):94-103.
  • Ibelings, B.W. and Maberly, S.C., (1998). Photoinhibition and The Availability of Inorganic Carbon Restrict Photosynthesis by Surface Blooms of Cyanobacteria. Limnol. Oceanogr. 43:408–419.
  • İspirli, S., (2009). İzmir Tahtalı Baraj Gölü’nün Toksik Siyanobakteri Türleri ve Bazı Mikrosistin Varyantları Yönünden Araştırılması. Doktora Tezi. Ege Üniversitesi Fen Bilimleri Enstitüsü, İzmir, 77 sayfa.
  • Janssen, E., (2019). Cyanobacterial Peptides Beyond Microcystins – A Review on Co-Occurrence, Toxicity and Challenges for Risk Assessment. Water Research. 151:488-499.
  • Ji, X., Verspagen, J.M.H., Stomp, M., and Huisman, J., (2017). Competition Between Cyanobacteria and Green Algae at Low Versus Elevated CO2: Who Will Win, and Why? J. Exp. Bot. 68:3815–3828.
  • Jochimsen, E.M., Carmichael, W.W., An, J., Cardo, D.M., Cookson, S.T., Holmes, C.E.M., Antunes, M.B.C., Filho D.A.M., Lyra, T.M., Barreto, V.S.T., Azevedo, S.M.F.O., and Jarvis, W.R., (1998). Liver Failure and Death After Exposure to Microcystins at A Hemodialysis Center in Brazil. N. Engl. J. Med. 338:873–878.
  • Jöhnk, K.D., (2008). Summer Heatwaves Promote Blooms of Harmful Cyanobacteria. Glob. Chang. Biol. 14:495–512.
  • Kahraman, S.D. and Küplülü, Ö., (2012). Siyanobakteriler ve Toksinleri. Vet Hekim Der. Dergisi. 83(2):36-47.
  • Krienitz, L. Ballot, A., Kotut, K., Wiegand, C., Pütz, S., Metcalf, J.S., Codd, A.G., and Pflugmacher, S., (2003). Contribution of Hot Spring Cyanobacteria to the Mysterious Deaths of Lesser Flamingos at Lake Bogoria, Kenya. FEMS Microbiology Ecology, 43:141-148.
  • Lehman, P.W., (2017). Impacts of the 2014 Severe Drought on the Microcystis Bloom in San Francisco Estuary. Harmful Algae, 63:94–108.
  • Lürling, M. and Faassen, E.J., (2012). Controlling Toxic Cyanobacteria: Effects of Dredging and Phosphorusbinding Clay on Cyanobacteria and Microcystins. Water Res. 46:1447–1459.
  • Matthijs, H.C.P., Jančula, D., Visser, P.M., and Maršálek, B., (2016). Existing and Emerging Cyanocidal Compounds: New Perspectives for Cyanobacterial Bloom Mitigation. Aquat. Ecol. 50:443–460.
  • Merel, S., Walker, D., Chicana, R., Snyder, S., Baures, E., and Thomas, O., (2013). State of Knowledge and Concerns on Cyanobacterial Blooms and Cyanotoxins. Environ. Int. 59:303–327.
  • Nellan, B.A., Pearson, L.A., Muenchhoff, J., Moffitt, M.C., and Dittmann, E., (2013). Environmental Conditions That Influence Toxin Biosynthesis in Cyanobacteria. Environ. Microbiol. 15:1239–1253.
  • O’Neil, J.M., Davis, T.W., Burford, M.A., and Gobler, C.J., (2012). The Rise of Harmful Cyanobacteria Blooms: Potential Role of Eutrophication and Climate Change. Harmful Algae, 14:313–334.
  • Osborne, N.J., Shaw, G.R., and Webb, P.M., (2007). Health Effects of Recreational Exposure to Moreton Bay, Australia Waters During a Lyngbya Majuscula Bloom. Environment International, 33(3):309-314.
  • Paerl, H.W. and Huisman, J., (2009). Climate Change: A Catalyst for Global Expansion of Harmful Cyanobacterial Blooms. Environ. Microbiol. Rep. 1:27–37.
  • Paerl, H.W. and Otten, T.G., (2013). Harmful Cyanobacterial Blooms: Causes, Consequences and Controls. Microb. Ecol. 65:995–1010.
  • Pearson, L., Mihali, T., Moffitt, M., Kellmann, R., and Neilan, B., (2010). On The Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin. Mar. Drugs 8:1650–1680.
  • Rantala, A., Fewer, D.P., Hisbergues, M., Rouhlainen, L., Valtomaa, J., Börner, T., and Sivonen, K., (2004). Phylogenetic Evidence for The Early Evolution of Microcystin Synthesis. Proc. Natl Acad.Sci. USA, 101:568–573.
  • Sandrini, G., Ji, X., Verspagen, J.M.H., Tann, R.P., Slot, P.C., Luimstra, V.M., Schuurmans, J.M., Matthijs, H.C.P., and Huisman, J. (2016). Rapid Adaptation of Harmful Cyanobacteria to Rising CO2. Proc. Natl Acad. Sci. USA, 112:9315–9320.
  • Scheffer, M., Hosper, S.H., Meijer, M.L., Moss, B., and Jeppesen, E., (1993). Alternative Equilibria in Shallow Lakes. Trends Ecol. Evol. 8:275–279.
  • Sondergaard, M., Jensen, J.P., and Jeppesen, E., (2003). Role of Sediment and Internal Loading of Phosphorus in Shallow Lakes. Hydrobiologia, 506:135–145.
  • Sondergaard, M., Jeppesen, E., Lauridsen, T.L., Skov, C., Van Nes, E.H., Roijackers, R., Lammens, E., and Portielje, R. (2007). Lake Restoration: Successes,Failures and Long- Term Effects. J. Appl. Ecol. 44:1095–1105.
  • Sondergaard, M., Lauridsen, T.L., Johansson, L.S., and Jeppesen, E., (2017). Repeated Fish Removal to Restore Lakes: Case Study of Lake Væng, Denmark, Two Biomanipulations During 30 Years of Monitoring. Water, 9:43.
  • Taranu, Z.E., Zurawell, R.W., Pick, F., and Gregory-Eaves, I., (2012). Predicting Cyanobacterial Dynamics in The Face of Global Change: The Importance of Scale and Environmental Context. Glob. Change Biol. 18:3477–3490.
  • van Apeldoorn, M., Van Egmond, H.P., Speijers, G.J.A., and Bakker, G.J.I., (2007). Toxins of Cyanobacteria. Mol. Nutr. Food Res., 51:7–60.
  • Van De Bund, W.J. and Van Donk, E., (2002). Short-Term and Long- Term Effects of Zooplanktivorous Fish Removal in a Shallow Lake: A Synthesis of 15 Years of Data From Lake Zwemlust. Freshwater Biol. 47:2380–2387.
  • Van Wichelen, J., Vanormelingen, P., Codd, G.A., and Vyverman, W., (2016). The Common Bloom- Forming Cyanobacterium Microcystis Is Prone to a Wide Array of Microbial Antagonists. Harmful Algae, 55:97–111.
  • Verspagen, J.M.H., Van de Waal, D.B., Finke, J.F., Visser, P.M., Van Donk, E., and Huisman, J., (2014). Rising CO2 Levels Will Intensify Phytoplankton Blooms in Eutrophic and Hypertrophic Lakes. PLOS ONE, 9, e104325.
  • Visser, P.M., Ibelings, B.W., Bormans, M., and Huisman, J., (2016a). Artificial Mixing to Control Cyanobacterial Blooms: A Review. Aquat. Ecol. 50:423–441.
  • Visser, P.M., Ibelings, B.W., Van der Veer, B., Koedood, J., and Mur, L.R., (1996). Artificial Mixing Prevents Nuisance Blooms of The Cyanobacterium Microcystis in Lake Nieuwe Meer, The Netherlands. Freshwater Biol. 36:435–450.
  • Visser, P.M., Verspagen, J.M.H., Sandrini, G., Stal, L.J., Matthijs, H.C.P., Davis, T.W., Paerl, H.W., and Huisman, J., (2016b). How Rising CO2 and Global Warming May Stimulate Harmful Cyanobacterial Blooms. Harmful Algae, 54:145–159.
  • Waajen, G.W.A M., Van Bruggen, N.C.B., Dionisio Pires, L.M., Lengkeek, W., and Lürling, M., (2016). Biomanipulation with Quagga Mussels (Dreissena rostriformis bugensis) to Control Harmful Algal Blooms in Eutrophic Urban Ponds. Ecol. Eng. 90:141–150.
  • White, J.D. and Sarnelle, O., (2014). Size- Structured Vulnerability of The Colonial Cyanobacterium, Microcystis aeruginosa, to Grazing By Zebra Mussels (Dreissena polymorpha). Freshwater Biol. 59:514–525.
  • WHO, (2011). Guidelines for Drinking Water Quality (4. Baskı). World Health Organization, Geneva, Switzerland.
  • Wiese, M., D’Agostino, P.M., Mihali, T.K., Moffitt, M.C., and Neilan, B.A., (2010). Neurotoxic Alkaloids: Saxitoxin and Its Analogs. Mar. Drugs 8:2185–2211.
  • Wood, S.A., Selwood, A.I., Rueckert, A., Holland, P.T., Milne, J.R., Smith, K.F., Smits, B., Watts, L.F., and Cary, C.S., (2007). First Report of Homoanatoxin-a and Associated Dog Neurotoxicosis in New Zealand. Toxicon, 50:292-301.
  • Zhao, C.S., Shao, N.F., Yang, S.T., Ren, H., Ge, Y.R., Feng, P., Dong, B.E., and Zhao, Y., (2019). Predicting Cyanobacteria Bloom Occurrence in Lakes and Reservoirs Before Blooms Occur. Science of the Total Environment, 670:837-848.
  • Zilliges, Y., Kehr, J.C., Meissner, S., Ishida, K., Mikkat, S., Hagemann, M., Kaplan, A., Börner, T., and Dittman, E., (2011). The Cyanobacterial Hepatotoxin Microcystin Binds to Proteins and Increases the Fitness of Microcystis Under Oxidative Stress Conditions. PLOS ONE, 6, e17615.
  • Price, G.D., Woodger, F.J., Badger, M.R., Howitt, S.M., and Tucker, L., (2004). Identification of a SulP-Type Bicarbonate Transporter in Marine Cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America, 101(52):18228-18233.
  • Mahmood, N.A. and Carmichael, W.W., (1987). Anatoxin-a (s), an Anticholinesterase from the Cyanobacterium Anabaena flos-aquae NRC-525-17. Toxicon, 25(11):1221-1227.
  • Nybom, S.M.K., Salminen, S.J., Meriluoto, and J.A.O., (2007). Removal of Microcystin-LR by Strains of Metabolically Active Probiotic Bacteria. FEMS Microbiology Letters. 270:27–33.
  • Nybom, S.M.K., Salminen, S.J., and Meriluoto, J.A.O., (2008). Specific Strains of Probiotic Bacteria Are Efficient in Removal of Several Different Cyanobacterial Toxins from Solution. Toxicon. 52:214–220.
  • Nybom, S.M.K., Dziga D., Heikkilä, J.E., Kull, T.P.J., Salminen, S.J., and Meriluoto, J.A.O., (2012). Characterization of Microcystin-LR Removal Process in the Presence of Probiotic Bacteria. Toxicon. 59:171–181.
  • Dziga, D., Kokocinski, M., Maksylewicz, A., Czaja-Prokop, U., and Barylski, J., (2016). Cylindrospermopsin Biodegradation Abilities of Aeromonas Sp. Isolated from Rusalka Lake. Toxins, 8(3):1-10.
Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Doğanay Yüksel 0000-0002-1926-5573

Elif Çelik 0000-0002-8280-8809

Özlem Turgay 0000-0003-2286-833X

Yayımlanma Tarihi 21 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 16 Sayı: 1

Kaynak Göster

APA Yüksel, D., Çelik, E., & Turgay, Ö. (2021). Siyanobakteri Kaynaklı Toksin Tehlikesi. Ecological Life Sciences, 16(1), 1-17.
AMA Yüksel D, Çelik E, Turgay Ö. Siyanobakteri Kaynaklı Toksin Tehlikesi. NWSA. Ocak 2021;16(1):1-17.
Chicago Yüksel, Doğanay, Elif Çelik, ve Özlem Turgay. “Siyanobakteri Kaynaklı Toksin Tehlikesi”. Ecological Life Sciences 16, sy. 1 (Ocak 2021): 1-17.
EndNote Yüksel D, Çelik E, Turgay Ö (01 Ocak 2021) Siyanobakteri Kaynaklı Toksin Tehlikesi. Ecological Life Sciences 16 1 1–17.
IEEE D. Yüksel, E. Çelik, ve Ö. Turgay, “Siyanobakteri Kaynaklı Toksin Tehlikesi”, NWSA, c. 16, sy. 1, ss. 1–17, 2021.
ISNAD Yüksel, Doğanay vd. “Siyanobakteri Kaynaklı Toksin Tehlikesi”. Ecological Life Sciences 16/1 (Ocak 2021), 1-17.
JAMA Yüksel D, Çelik E, Turgay Ö. Siyanobakteri Kaynaklı Toksin Tehlikesi. NWSA. 2021;16:1–17.
MLA Yüksel, Doğanay vd. “Siyanobakteri Kaynaklı Toksin Tehlikesi”. Ecological Life Sciences, c. 16, sy. 1, 2021, ss. 1-17.
Vancouver Yüksel D, Çelik E, Turgay Ö. Siyanobakteri Kaynaklı Toksin Tehlikesi. NWSA. 2021;16(1):1-17.