EN
Stem cell therapy in knee osteoarthritis, a recent literature review
Abstract
Cell-based therapy and novel approaches using mesenchymal stromal cells (MSCs) has been explored in recent years as a new regenerative therapy for knee osteoarthritis. MSCs are envisioned as the most extensively explored new therapeutic drugs in the treatment of cell-based osteoarthritis due to their ability to differentiate into chondrocytes and their immunomodulatory properties. Various procedures for cell selection and preparation have been described in studies on MSCs. This article focuses on a review of the available literature on MSC based cell therapy in primary knee osteoarthritis. Promising results have been obtained for cartilage repair in around thirty human studies. These results are like other cartilage repair methods, with good results in approximately 80% of the cases. However, the number of patients in stem cell studies is small and the follow-up period is very short. The new cartilage formed is a repair tissue and does not have the original cartilage structure. Therefore, there is not enough information about the long-term results of this treatment. It has not been shown to be superior to other cartilage repair methods. Orthopedic use of stem cells is still in its infancy. Although the results obtained are promising, they are not yet included in standard treatment protocols. Stem cell research continues all over the world, but the ideal application method is unknown. There is a need for further clinical studies with a larger patient populations and longer follow-up periods.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Review
Early Pub Date
August 1, 2023
Publication Date
July 19, 2023
Submission Date
July 27, 2022
Acceptance Date
August 16, 2022
Published in Issue
Year 2023 Volume: 40 Number: 2
APA
Yurtbay, A., & Say, F. (2023). Stem cell therapy in knee osteoarthritis, a recent literature review. Deneysel Ve Klinik Tıp Dergisi, 40(2), 383-389. https://izlik.org/JA78RP95KD
AMA
1.Yurtbay A, Say F. Stem cell therapy in knee osteoarthritis, a recent literature review. J. Exp. Clin. Med. 2023;40(2):383-389. https://izlik.org/JA78RP95KD
Chicago
Yurtbay, Alparslan, and Ferhat Say. 2023. “Stem Cell Therapy in Knee Osteoarthritis, a Recent Literature Review”. Deneysel Ve Klinik Tıp Dergisi 40 (2): 383-89. https://izlik.org/JA78RP95KD.
EndNote
Yurtbay A, Say F (July 1, 2023) Stem cell therapy in knee osteoarthritis, a recent literature review. Deneysel ve Klinik Tıp Dergisi 40 2 383–389.
IEEE
[1]A. Yurtbay and F. Say, “Stem cell therapy in knee osteoarthritis, a recent literature review”, J. Exp. Clin. Med., vol. 40, no. 2, pp. 383–389, July 2023, [Online]. Available: https://izlik.org/JA78RP95KD
ISNAD
Yurtbay, Alparslan - Say, Ferhat. “Stem Cell Therapy in Knee Osteoarthritis, a Recent Literature Review”. Deneysel ve Klinik Tıp Dergisi 40/2 (July 1, 2023): 383-389. https://izlik.org/JA78RP95KD.
JAMA
1.Yurtbay A, Say F. Stem cell therapy in knee osteoarthritis, a recent literature review. J. Exp. Clin. Med. 2023;40:383–389.
MLA
Yurtbay, Alparslan, and Ferhat Say. “Stem Cell Therapy in Knee Osteoarthritis, a Recent Literature Review”. Deneysel Ve Klinik Tıp Dergisi, vol. 40, no. 2, July 2023, pp. 383-9, https://izlik.org/JA78RP95KD.
Vancouver
1.Alparslan Yurtbay, Ferhat Say. Stem cell therapy in knee osteoarthritis, a recent literature review. J. Exp. Clin. Med. [Internet]. 2023 Jul. 1;40(2):383-9. Available from: https://izlik.org/JA78RP95KD
