Brain imaging findings of methanol poisoning and detection of chronic stage nervous system damage: A case report

Year 2023, Volume: 40 Issue: 1, 180 - 182, 18.03.2023

Fatma Yilmaz Can , Mehmet Fevzi Öztekin

Abstract

In this article, we presented the chronic neurological findings of an acute case of methanol intoxication due to the use of homemade alcohol. In the neurological examination performed 6 months after intoxication, bilateral vision loss, tremor, dysarthria, dysphagia, loss of taste sensation, and decrease in the Cognitive State Test score were detected. Peripheral polyneuropathy consistent with axonopathy was detected in the peripheral nerve conduction study, and optical neuropathy was detected in the examination of the pattern visual evoked potential. Brain magnetic resonance imaging revealed findings compatible with bilateral putaminal necrosis.

Keywords

Methanol intoxication , putaminal hemorrhagic necrosis , optic neuropathy , polyneuropathy , cognition

References

• References 1.Ott J. Gronemann V, Pontzen F. Methanol. Ullmann’s Encyclopedia of Industrial Chemistry. 2000; 27(2):403–404.
• 2. Rietjens SJ, de Lange DW, Meulenbelt J. Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 2014; 72(2):73-79.
• 3. Kraut JA. Approach to the treatment of methanol intoxication. Am J Kidney Dis. 2016; 68(1):161-167.
• 4. Paasma R, Hovda KE, Jacobsen D. Methanol poisoning and long term sequelae - A six years follow-up after a large methanol outbreak. BMC Clin Pharmacol. 2009; 9:5.
• 5. Jarwani BS, Motiani P, Divetia R, Thakkar G. Rare combination of bilateral putaminal necrosis, optic neuritis, and polyneuropathy in a case of acute methanol intoxication among patients met with hooch tragedy in Gujarat, India. J Emerg Trauma Shock. 2012; 5(4): 356–359.
• 6. Choi JH, Lee SK, Gil YE, Ryu J, Jung-Choi K, Kim H, et al. Neurological complications resulting from non-oral occupational methanol poisoning. J Korean Med Sci. 2017; 32(2):371-376.
• 7. Andresen H, Schmoldt H, Matschke J, Flachskampf FA, Turk EE. Fatal methanol intoxication with different survival times—morphological findings and postmortem methanol distribution. Forensic Sci Int. 2008; 179(2–3):206–210.
• 8. Taheri MS, Moghaddam HH, Moharamzad Y, Dadgari S, Nahvi V. The value of brain CT findings in acute methanol toxicity. Eur J Radiol. 2010; 73:211–214.
• 9. Broadley S, Ferguson I, Walton B, Tomson C. Severe sensorimotor polyradiculoneuropathy after ingestion of ethyleneglycol. J Neurol Neurosurg Psychiatry. 1997; 63(2): 261. 10. Grzybowski A, Zülsdorff M, Wilhelm H, Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015; 93(5):402-410.