Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs)

Ahmad Ali; Farhat Chaudhari; Prairna Balyan

EN

Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs)

Abstract

Diabetes mellitus (DM) is one of the world's most common diseases. Its impact on the male reproductive system is one of its key impacts. Erectile dysfunction and decreased libido affect up to 90% of diabetic men, which can result in male infertility. Several researchers have investigated the negative impacts of reactive oxygen species and the subsequent development of oxidative stress that occurs due to DM. Non-enzymatic glycosylation products (AGEs) have been found in diabetic men's reproductive tracts. AGEs work by generating reactive oxygen species (ROS) or attaching to receptors on their own. The binding of AGE to the receptor (RAGE) has been demonstrated to play a role in physiological processes such as lung homeostasis, bone metabolism, neural systems, and the immune system. The human body has several defenses against AGE accumulation, which are reduced in diabetic individuals. The situation can be improved by using some preventive measures, either by using oral drugs or natural therapeutic agents. Also, herbal medicine is gaining popularity in the market to treat various ailments. Because of the long cultural history of use and the present resurgent interest, using herbal treatments to manage male sexual dysfunction is beneficial.

Keywords

Supporting Institution

Research Society for Studies on Diabetes in India (RSSDI)

Project Number

RSSDI/HQ/Grants/2017/342

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Ahmad Ali ^*
0000-0003-4467-5387
India

Farhat Chaudhari This is me
0000-0002-9946-4555
India

Prairna Balyan This is me
0000-0003-0137-105X
India

Early Pub Date

August 1, 2023

Publication Date

July 19, 2023

Submission Date

September 14, 2022

Acceptance Date

March 20, 2023

Published in Issue

Year 2023 Volume: 40 Number: 2

IZ

https://izlik.org/JA24NP53ZK

Cite

RIS / Bibtex

APA

Ali, A., Chaudhari, F., & Balyan, P. (2023). Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs). Deneysel Ve Klinik Tıp Dergisi, 40(2), 390-400. https://izlik.org/JA24NP53ZK

AMA

1.Ali A, Chaudhari F, Balyan P. Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs). J. Exp. Clin. Med. 2023;40(2):390-400. https://izlik.org/JA24NP53ZK

Chicago

Ali, Ahmad, Farhat Chaudhari, and Prairna Balyan. 2023. “Mechanisms and Therapeutic Opportunities in Erectile Dysfunction for Advanced Glycation End Products (AGEs)”. Deneysel Ve Klinik Tıp Dergisi 40 (2): 390-400. https://izlik.org/JA24NP53ZK.

EndNote

Ali A, Chaudhari F, Balyan P (July 1, 2023) Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs). Deneysel ve Klinik Tıp Dergisi 40 2 390–400.

IEEE

[1]A. Ali, F. Chaudhari, and P. Balyan, “Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs)”, J. Exp. Clin. Med., vol. 40, no. 2, pp. 390–400, July 2023, [Online]. Available: https://izlik.org/JA24NP53ZK

ISNAD

Ali, Ahmad - Chaudhari, Farhat - Balyan, Prairna. “Mechanisms and Therapeutic Opportunities in Erectile Dysfunction for Advanced Glycation End Products (AGEs)”. Deneysel ve Klinik Tıp Dergisi 40/2 (July 1, 2023): 390-400. https://izlik.org/JA24NP53ZK.

JAMA

1.Ali A, Chaudhari F, Balyan P. Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs). J. Exp. Clin. Med. 2023;40:390–400.

MLA

Ali, Ahmad, et al. “Mechanisms and Therapeutic Opportunities in Erectile Dysfunction for Advanced Glycation End Products (AGEs)”. Deneysel Ve Klinik Tıp Dergisi, vol. 40, no. 2, July 2023, pp. 390-0, https://izlik.org/JA24NP53ZK.

Vancouver

1.Ahmad Ali, Farhat Chaudhari, Prairna Balyan. Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs). J. Exp. Clin. Med. [Internet]. 2023 Jul. 1;40(2):390-40. Available from: https://izlik.org/JA24NP53ZK