Osteopontin, Suppression of Tumorgenicity 2 and Myeloperoxidase Levels in Acute Coronary Syndrome Patients with Fragmented QRS

Abstract

Background/aim: In recent years, studies have focused on new markers to predict the risk of cardiovascular diseases (CVD). There are several studies analyzing biomarkers such as myeloperoxidase (MPO), suppression of tumorgenicity 2 (sST2), and osteopontin (OPN) in CVD, however, there are no studies that show their relationship in patients who have fragmented QRS (fQRS). It was aimed to investigate the OPN, sST2, and MPO levels in patients who were diagnosed with the acute coronary syndrome (ACS) in the present study. Materials and Methods: Sixty ACS patients and 26 healthy individuals were included in the study. Patients diagnosed ACS were divided into two groups as (+)fQRS (n=30) and (-)fQRS (n=30). Levels of OPN and sST2 were measured by ELISA, and also MPO was measured by colorimetric methods. Results: In ACS patients, serum MPO (33.7 U/L), OPN (103.29 ng/mL) and sST2 (495.4 pg/mL) levels were found significantly higher than the control group (23.14 U/L, 42.65 ng/mL, 344.11 pg/mL, respectively; p<0.01, p<0.01, p<0.05). However, there were no significant differences between MPO, OPN and sST2 levels in patients with (+)fQRS (respectively, 32.74 U/L, 101.89 ng/mL and 451.97 pg/mL) and (-)fQRS (respectively, 34.67 U/L, 104.69 ng/mL, 535.73 pg/mL). There were also positive correlations between MPO and platelet (r=0.376, p<0.05) levels in the (+)fQRS group, and sST2 and triglyceride levels in the (-)fQRS group. When the diagnostic performances for ACS were examined, the sensitivity of CK-MB, troponin-I, MPO, OPN and sST2 were 83%, 80%, 65%, 85%, 58% and specificity 96%, 100%, 72%, 96%, 80%, respectively. Conclusions: In conclusion, MPO, OPN, and sST2 may be included in the factors that may contribute to the diagnosis and development of ACS. In addition, the discovery of the high diagnostic sensitivity and specificity of OPN in acute coronary syndrome is a new finding obtained in this study.

Keywords

• Acute coronary syndrome
• osteopontin
• sST2
• myeleporoxidase

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