Does Insulin Resistance Increase the Probability of Fibrocystic Breast Disease in Women with Polycystic Ovary Syndrome

Abstract

The aim of this study was to investigate if higher insulin resistance (IR) levels among polycystic ovary syndrome (PCOS) patients are the predictor of the fibrocystic breast disease risk in women aged 30-40 years. This case-control retrospective observational study was carried out on 180 patients admitted between September 2020 and June 2022. Women aged 18-36 years diagnosed with PCOS included the study. Women who were diagnosed with PCOS but not fibrocystic breasts formed the control group. Women were divided according to their IR levels into four groups. The optimal insulin (23.6% vs. 54.65), the insulin sensitivity (22.7% vs. 28.6), early IR (29.1% vs. 18.6), and significant IR (24.5% vs. 25.7) were similar between women with fibrocystic breasts and normal breasts, respectively. This study showed no statistically significant difference between women with fibrocystic breasts and normal breasts in study parameters (p-value > 0.05). There was no statistically difference between two groups in terms of IR levels. The results show that IR levels cannot be used to assess fibrocystic breast disease in PCOS women.

Keywords

• Insulin resistance
• polycystic ovarian syndrome
• benign breast disease
• fibrocystic breast changes

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