Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis

Abstract

Rheumatoid arthritis is associated with systemic bone mass loss due to stimulation of osteoclastogenesis and suppression of osteoblastogenesis through inhibition of Wingless (Wnt)/β catenin canonical and bone morphogenetic proteins (BMP) pathways by sclerostin. Our study assessed the correlation between tumor necrosis factor (TNF)-α and sclerostin with bone resorption markers C-terminal telopeptides of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in pre-menopausal rheumatoid arthritis patients. This cross-sectional study involved 38 premenopausal women with RA. Serum TNF-α, sclerostin, P1NP, and CTX level were examined by ELISA method. This study revealed high level of serum CTX (mean 2.74 ng/mL) and a low level of P1NP (median 34.04 pg/mL). There was a significant negative correlation (r = -0.388) between TNF-α and sclerostin levels (p = 0.016), as well as a significant positive correlation (r = 0.362) between TNF-α and P1NP levels (p = 0.026). There was a significant negative correlation between TNF-α and sclerostin, and also a significant positive correlation between TNF-α and P1NP in our study.

Keywords

• Bone remodelling
• premenopause
• rheumatoid arthritis
• tumor necrosis factor-alpha
• Wnt signaling pathway

Supporting Institution

Universitas Indonesia

Ethical Statement

This study had been approved by the Medical Research Ethics Committee of Universitas Indonesia Protocol Number KET- 377/UN2.F1/ETIK/ PPM.00.02/2019

Thanks

The authors wish to thank Harry Isbagio, Zuljasri Albar, Bambang Setyohadi, Suryo Anggoro, and Anna Ariane for their time and tremendous support in the field. This study was supported by Universitas Indonesia PITTA B Grant Scheme (Grant Number PENG- 1/UN2.R3.1/PPM.00/2019)

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