Effect of COVID-19 mRNA vaccine on serum AMH, TSH, FSH and LH concentrations

Abstract

The aim of our study is to evaluate the effect of COVID-19 vaccination on serum anti-Müllerian hormone (AMH) level and female reproductive system. The study included 111 women who applied to the infertility clinic between December 2020 and September 2022 and received two doses of COVID-19 mRNA vaccine (BNT162b2, - Pfizer-BioNTech). Serum hormone levels (anti-Müllerian hormone (AMH), Thyroid Stimulating Hormone (TSH), Follicle Stimulating Hormone (FSH), and Luteinizing Hormone (LH) hormones) of women before and after vaccination were evaluated and compared. Serum AMH level was 1.90±2.48 (mean ± SD) before vaccination and 1.87±2.16 (mean ± SD) after vaccination (p = 0.052). Although there was a minimal decrease in AMH levels, no statistically significant difference was detected. TSH, FSH and LH serum levels were similar before and after vaccination and no statistical difference was detected. Our study indicates that the COVID-19 mRNA vaccine does not have a negative effect on serum AMH, TSH, FSH and LH levels.

Keywords

• Anti-Müllerian hormone
• Coronavirus disease-19
• mRNA vaccine
• infertility
• ovarian reserve

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