The relationships between Aplein, Vaspin and thyroid hormone levels in obese diabetic and non-diabetic women

Abstract

Apelin and vaspin modulate thyroid function. Furthermore, they are connected to particular components of chemical elements. Increased apelin and vaspin in diabetic women can have a negative impact on their thyroid function. The aim of the study was to understand the relationship between thyroid hormones and adipokine as a way to find a solution to the problem of obesity or its complications. Between October 1, 2022, and February 2, 2023, the case-control study included a total of 150 women, 100 obese women as the case group (50 obese and diabetic, 50 obese without diabetic), and 50 healthy women as the control group. They visited Al-Habbobi and Al-Nasiriyia teaching hospitals. Vaspin and apelin were measured using the enzyme-linked immunosorbent assay (ELISA), whereas C-Peptide was assessed using the electrochemiluminescence immunoassay (ECLIA) for thyroid hormone (FT3, FT4, and TSH). The measurement of fasting blood sugar (FBS) and haemoglobinA1C (HBA1C) was conducted using colorimetric and fluorescence immunoassay (FIA), respectively. In the results, in obese diabetics, vaspin is significantly lower than in controls. Although there is no significant difference in apelin levels between groups (0.34± 0.08 vs. 0.32± 0.11, P = 0,09), Vaspin and apelin tests show no significant difference between obese non-diabetics and controls. FT3 and TSH levels are significantly higher in obese diabetics and non-diabetics than in the control group. While FT4 dropped significantly between groups, in obese diabetics, FT3 and TSH levels are significantly higher than in obese non-diabetics. Obese diabetics had a significantly lower decrease in vaspin and apelin levels than obese non-diabetic patients. In conclusion, the decrease in FT4 across all groups and vaspin levels in obesity and diabetes suggest that vaspin is involved in thyroid hormone metabolism. Despite lower thyroid hormone levels, apelin levels were not statistically different. This suggests that the thyroid gland controls fat levels and metabolism.

Keywords

• Adipocytokines
• obesity
• apelin
• vaspin
• biomarkers
• type 2 diabetes Mellitus
• hypothyroidism

Supporting Institution

Al-Nahrain University, Mazaya university collage

Ethical Statement

Written illustrative consent form was signed by all parents/caregivers of the participating patients. This study was performed according to the ethical rules for medical research involving human participants of the Declaration of Helsinki (1964). Ethical approval was received from the ethical and research committee of Department of Chemistry and Biochemistry, College of Medicine, Al- Nahrain University, Baghdad, Iraq

Thanks

The authors are thanks to all participants in this research.

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