A rare variant of glioblastoma is gliosarcoma: 11-case clinical trial

Abstract

Gliosarcoma is a rare subtype of glioblastoma, IDH wild type. Its characteristic features are a biphasic configuration with mixed glial and mesenchymal components. Here in, we present a rare case of Gliosarcoma that has been operated in our clinic in the last 10 years. Patients with gliosarcoma pathology results were collected from the ones operated in our faculty within 10 years. Patients from all age groups were included in the study. 1 of 11 gliosarcoma cases was described in detail. Seven of the cases were male, while 4 were female. Regarding tumor location, six 6 were located in the right, while 5 were in the left hemisphere. The average survival time of all 11 patients was 11 months. In 6 cases, the initial pathologic diagnosis was gliosarcoma, while in 5 cases, it was glioblastoma, and in the 2nd case, the pathology result was gliosarcoma. Gliosarcomas have a worse prognosis in terms of survival. Clinically, it is not possible to distinguish between glioblastomas and gliosarcomas. Treatment proceeds in the same way.

Keywords

• Glioblastoma
• Gliosarcoma
• Isocitrate dehydrogenase

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