Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients

Ümit Yavuz Keleş; Sami Fidan; Ceren Konca; Seher Nazlı Kazaz; Murat Erkut; Arif Mansur Coşar

Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients

Abstract

Current guidelines recommend that patients with cirrhosis be screened for the development of HCC every 6 months. The aim of our study was to determine whether HCC screening is performed with appropriate methods and at appropriate intervals in cirrhotic patients, and to evaluate the outcomes of the screening. This research is a retrospective cohort study. The study included patients aged 18 and over, diagnosed with Child-Pugh class A or B cirrhosis, who applied to our clinic between 2010 and 2020. Patients were divided into two groups: those who underwent guideline-recommended surveillance (imaging with ultrasound, CT, or MRI and/or measurement of AFP every 4-8 months) and those who did not undergo recommended surveillance (insufficient screening or no screening). These groups were compared in terms of HCC development, curative treatment, and survival. A total of 641 cirrhotic patients were included in the study. Only 146 (22.7%) patients underwent guideline-recommended HCC screening. During the follow-up period, a total of 89 patients were diagnosed with HCC (42 patients (28.8%) in the surveillance group and 47 patients (9.5%) in the nonsurveillance group, p<0.001). In the surveillance group, the rate of early-stage HCC detection (83.3% vs. 40.4%), curative treatment rate (78.4% vs. 33.3%), and median survival time (74 vs. 21.7 months) were higher compared to the nonsurveillance group (p<0.001). HCC screening rates in cirrhotic patients are quite low. Guideline-recommended HCC screening in these patients results in earlier diagnosis and increases both the likelihood of receiving curative treatment and overall survival.

Keywords

Supporting Institution

NO

Ethical Statement

The study was approved by the Karadeniz Technical University Health Application and Research Center Ethics Committee dated 14.12.2020 and numbered 48814514-501.07.01-E.14680.

Thanks

I would like to thank the reviewers who contributed to the publication of our article, the editor and the secretariat of the journal.

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Details

Primary Language

English

Subjects

Gastroenterology and Hepatology, Clinical Oncology

Journal Section

Research Article

Authors

Ümit Yavuz Keleş ^*
0000-0002-4946-5867
Türkiye

Sami Fidan
0000-0002-7412-4319
Türkiye

Ceren Konca This is me
0000-0003-4182-1879
Türkiye

Seher Nazlı Kazaz
0000-0002-8181-000X
Türkiye

Murat Erkut
0000-0003-3613-3449
Türkiye

Arif Mansur Coşar
0000-0002-4472-2895
Türkiye

Publication Date

June 30, 2025

Submission Date

January 8, 2025

Acceptance Date

June 27, 2025

Published in Issue

Year 2025 Volume: 42 Number: 2

IZ

https://izlik.org/JA48WC53ND

Cite

RIS / Bibtex

APA

Keleş, Ü. Y., Fidan, S., Konca, C., Kazaz, S. N., Erkut, M., & Coşar, A. M. (2025). Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients. Deneysel Ve Klinik Tıp Dergisi, 42(2), 152-158. https://izlik.org/JA48WC53ND

AMA

1.Keleş ÜY, Fidan S, Konca C, Kazaz SN, Erkut M, Coşar AM. Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients. J. Exp. Clin. Med. 2025;42(2):152-158. https://izlik.org/JA48WC53ND

Chicago

Keleş, Ümit Yavuz, Sami Fidan, Ceren Konca, Seher Nazlı Kazaz, Murat Erkut, and Arif Mansur Coşar. 2025. “Compliance With Hepatocellular Carcinoma Screening and the Effectiveness of Screening in Cirrhotic Patients”. Deneysel Ve Klinik Tıp Dergisi 42 (2): 152-58. https://izlik.org/JA48WC53ND.

EndNote

Keleş ÜY, Fidan S, Konca C, Kazaz SN, Erkut M, Coşar AM (June 1, 2025) Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients. Deneysel ve Klinik Tıp Dergisi 42 2 152–158.

IEEE

[1]Ü. Y. Keleş, S. Fidan, C. Konca, S. N. Kazaz, M. Erkut, and A. M. Coşar, “Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients”, J. Exp. Clin. Med., vol. 42, no. 2, pp. 152–158, June 2025, [Online]. Available: https://izlik.org/JA48WC53ND

ISNAD

Keleş, Ümit Yavuz - Fidan, Sami - Konca, Ceren - Kazaz, Seher Nazlı - Erkut, Murat - Coşar, Arif Mansur. “Compliance With Hepatocellular Carcinoma Screening and the Effectiveness of Screening in Cirrhotic Patients”. Deneysel ve Klinik Tıp Dergisi 42/2 (June 1, 2025): 152-158. https://izlik.org/JA48WC53ND.

JAMA

1.Keleş ÜY, Fidan S, Konca C, Kazaz SN, Erkut M, Coşar AM. Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients. J. Exp. Clin. Med. 2025;42:152–158.

MLA

Keleş, Ümit Yavuz, et al. “Compliance With Hepatocellular Carcinoma Screening and the Effectiveness of Screening in Cirrhotic Patients”. Deneysel Ve Klinik Tıp Dergisi, vol. 42, no. 2, June 2025, pp. 152-8, https://izlik.org/JA48WC53ND.

Vancouver

1.Ümit Yavuz Keleş, Sami Fidan, Ceren Konca, Seher Nazlı Kazaz, Murat Erkut, Arif Mansur Coşar. Compliance with hepatocellular carcinoma screening and the effectiveness of screening in cirrhotic patients. J. Exp. Clin. Med. [Internet]. 2025 Jun. 1;42(2):152-8. Available from: https://izlik.org/JA48WC53ND