Effects of sertraline use on bone microarchitecture: A literature review

Büşra Nur Özcan; Ahmet Uzun

Effects of sertraline use on bone microarchitecture: A literature review

Abstract

Selective serotonin reuptake inhibitors (SSRIs), particularly sertraline, are widely prescribed for depression and anxiety disorders. Although primarily targeting the central nervous system, emerging evidence suggests that SSRIs can significantly impact bone health. This narrative review aims to evaluate the clinical effects of long-term SSRI use on bone mineral density (BMD) and fracture risk. A literature review was conducted across PubMed, Scopus, Web of Science, and Google Scholar, covering studies from 1998 to 2025. Results from both preclinical and clinical data consistently demonstrate a reduction in BMD associated with prolonged SSRI exposure, particularly in trabecular-rich anatomical regions such as the femoral neck, vertebrae, and mandible. These changes have been linked to decreased osteoblastic activity and increased bone resorption, leading to structural weakening and elevated fracture risk. Clinical findings suggest that elderly individuals and postmenopausal women are especially vulnerable, and that fracture risk appears to correlate with both the dose and duration of SSRI therapy. While the exact molecular mechanisms remain under investigation, the clinical implications are clear: bone health assessment and monitoring should be integral to the care of patients prescribed SSRIs, particularly those with additional risk factors for osteoporosis. Interventions such as BMD screening, calcium and vitamin D supplementation, and lifestyle modifications may be beneficial in reducing skeletal complications. This review underscores the need for increased clinical awareness and interdisciplinary management strategies to mitigate potential bone-related side effects of SSRI treatment in at-risk populations.

Keywords

Ethical Statement

This study is a literature review and does not involve any human or animal subjects. Therefore, ethical committee approval is not required.

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Details

Primary Language

English

Subjects

Clinical Pharmacology and Therapeutics, Psychiatry

Journal Section

Review

Authors

Büşra Nur Özcan ^*
0000-0002-1160-4542
Türkiye

Ahmet Uzun
0000-0003-4147-3798
Türkiye

Publication Date

September 30, 2025

Submission Date

May 24, 2025

Acceptance Date

July 16, 2025

Published in Issue

Year 2025 Volume: 42 Number: 3

IZ

https://izlik.org/JA48YD45UY

Cite

RIS / Bibtex

APA

Özcan, B. N., & Uzun, A. (2025). Effects of sertraline use on bone microarchitecture: A literature review. Deneysel Ve Klinik Tıp Dergisi, 42(3), 324-337. https://izlik.org/JA48YD45UY

AMA

1.Özcan BN, Uzun A. Effects of sertraline use on bone microarchitecture: A literature review. J. Exp. Clin. Med. 2025;42(3):324-337. https://izlik.org/JA48YD45UY

Chicago

Özcan, Büşra Nur, and Ahmet Uzun. 2025. “Effects of Sertraline Use on Bone Microarchitecture: A Literature Review”. Deneysel Ve Klinik Tıp Dergisi 42 (3): 324-37. https://izlik.org/JA48YD45UY.

EndNote

Özcan BN, Uzun A (September 1, 2025) Effects of sertraline use on bone microarchitecture: A literature review. Deneysel ve Klinik Tıp Dergisi 42 3 324–337.

IEEE

[1]B. N. Özcan and A. Uzun, “Effects of sertraline use on bone microarchitecture: A literature review”, J. Exp. Clin. Med., vol. 42, no. 3, pp. 324–337, Sept. 2025, [Online]. Available: https://izlik.org/JA48YD45UY

ISNAD

Özcan, Büşra Nur - Uzun, Ahmet. “Effects of Sertraline Use on Bone Microarchitecture: A Literature Review”. Deneysel ve Klinik Tıp Dergisi 42/3 (September 1, 2025): 324-337. https://izlik.org/JA48YD45UY.

JAMA

1.Özcan BN, Uzun A. Effects of sertraline use on bone microarchitecture: A literature review. J. Exp. Clin. Med. 2025;42:324–337.

MLA

Özcan, Büşra Nur, and Ahmet Uzun. “Effects of Sertraline Use on Bone Microarchitecture: A Literature Review”. Deneysel Ve Klinik Tıp Dergisi, vol. 42, no. 3, Sept. 2025, pp. 324-37, https://izlik.org/JA48YD45UY.

Vancouver

1.Büşra Nur Özcan, Ahmet Uzun. Effects of sertraline use on bone microarchitecture: A literature review. J. Exp. Clin. Med. [Internet]. 2025 Sep. 1;42(3):324-37. Available from: https://izlik.org/JA48YD45UY