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Assessment of ovarian tumor marker CA-125 during radiotherapy course

Year 2013, , 137 - 139, 31.07.2013
https://doi.org/10.5835/jecm.omu.30.02.010

Abstract

The antigen secretion by ovarian cancer (CA-125) has been assessed using Radio Immune Assay (RIA) technique among a hundred ovarian cancer patients who received radiotherapy course as radical treatment. The study revealed that, the ovarian cancer commonly associated with the age groups of 30-40 years old taking a percent of 68 relative to other age groups and the antigen CA-125 does not has relation with aging. While the radiotherapy shows it is efficiency in management of ovarian cancer by reducing the antigen CA-125 level from 134 ± 13.3 U/ml to 5.5 ± 2.1 U/ml relative to normal level of CA-125 (35 U/ml). Also there is significant relationship between the
cancer stage and the level of antigen CA-125 (R2=0.98).

References

  • ACOG: American College of Obstetricians and Gynecologists, 2002. The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Obstet. Gynecol. 100, 1413-1416.
  • American Cancer Society. Cancer Facts and Figures. (2012). Atlanta, GA.
  • Bast, R.C. Jr., Feeney, M., Lazarus, M., Nadler, L.M., Colvin, R.B., Knapp, R.C., 1981. Reactivity of a monoclonal antibody with human ovarian carcinoma. J. Clin. Invest. 68, 1331-1337.
  • Bast, R.C. Jr., Klug, T.L., ST. John, E., 1983. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 308, 883-887.
  • Bhattacharya, M., Chatterjee, S.K., Barlow, J.J., Fuji, H. 1982. Monoclonal antibodies recognizing Tumour-associated antigens of human ovar- ian mucinous cystadenocarcinomas. Cancer Res. 42, 1650-1654.
  • Canney, P.A., Moore M., Wilkinson, P.M., James, R.D., 1984. Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumor marker. Brth. J. Cancer. 50, 765-769.
  • Coussy, F., Chéreau, E., Daraï, E., Dhombres, F., Lotz, J.P., Rouzier, R., Selle, F., 2011. Interest of CA 125 level in management of ovarian can- cer. Gynecol. Obstet. Fertil. 39, 296-301.
  • Donaldson, E.S., Van Nagell, J.R., Pursell, S., 1980. Multiple biochemical markers on patients with gynaecologic malignancies. Cancer. 45, 948-953.
  • Goone Wardene, T.I., 2007. Management of asymptomatic patients on follow-up for ovarian cancer with rising CA-125 concentrations. Lancet Oncol. 8, 813-821.
  • Gregory, P. Beehler., Manveen S., Julie, A. B., Barbara E. T., Susan, E. M., Kerry J. R., and Kirsten B. M., 2006. Risk of ovarian cancer associ- ated with BMI varies by menopausal status.J. Nutr. 136, 2881–2886.
  • Hogdall, E., 2008. Cancer antigen CA-125 and prognosis. Curr. Opin. Obstet. Gynecol. 20, 4-8.
  • Keys, A., Fidanza, F., Karvonen, M.J., Kimura, N., Taylor, H.L., 1972. Indices of relative weight and adiposity. J. Chronic. Dis. 25, 329-343.
  • Kramer, J.L., Greene, M.H., 2004. Epidemiology of Ovarian, Fallopian Tube, and Primary Peritoneal Cancers. in: Gynecologic Cancer: Contro- versies in Management. Gershenson, D., Gore, M., McGuire, W., Quinn, M., Thomas, G., editors. Elsevier Science. pp. 327-340.
  • Manolov, V., Marinov, B., Vasilev, V., 2012. HE4 and CA125 in ovarian cancer. Akush. Ginekol. 51, 21-28.
  • NCCN: National Comprehensive Cancer Network, 2009. NCCN Practice Guidelines in Oncology: Ovarian cancer, Vol. 2.
  • Rustin, G.J.S., Nelstrop, A.E., Bentzen, S.M., Piccart, M.J., Bertelsen, K., 1999. Use of tumour markers in monitoring the course of ovarian cancer. Ann. Oncology. 10, 21-27.
  • Rustin, G.J.S., Nelstrop, A.E., Tuxen, M.K, Lambert, H.E., 1996. Defining progression of ovarian carcinoma during follow-up according to CA-125: A North Thames Ovary Group Study. Ann. Oncology. 7, 361-364.
  • Sproston, A.R.M., Roberts, S.A., Davidson, S.E., Hunter, R.D. , West, C.M.L., 1995. Serum tumor markers in carcinoma of the uterine cervix and outcome following radiotherapy. Brith. J. Cancer. 72,1536-1540.
  • Tietz, N.W. (Ed)., 1995. Clinical guide to laboratory tests, 3rd. ed. W. B. Saunders, Philadelphia, PA .pp.
  • Yin, B.W., Lloyd, K.O., 2001. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J. Biol. Chem. 276, 27371-27375. Ali Omer et al.
Year 2013, , 137 - 139, 31.07.2013
https://doi.org/10.5835/jecm.omu.30.02.010

Abstract

References

  • ACOG: American College of Obstetricians and Gynecologists, 2002. The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Obstet. Gynecol. 100, 1413-1416.
  • American Cancer Society. Cancer Facts and Figures. (2012). Atlanta, GA.
  • Bast, R.C. Jr., Feeney, M., Lazarus, M., Nadler, L.M., Colvin, R.B., Knapp, R.C., 1981. Reactivity of a monoclonal antibody with human ovarian carcinoma. J. Clin. Invest. 68, 1331-1337.
  • Bast, R.C. Jr., Klug, T.L., ST. John, E., 1983. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 308, 883-887.
  • Bhattacharya, M., Chatterjee, S.K., Barlow, J.J., Fuji, H. 1982. Monoclonal antibodies recognizing Tumour-associated antigens of human ovar- ian mucinous cystadenocarcinomas. Cancer Res. 42, 1650-1654.
  • Canney, P.A., Moore M., Wilkinson, P.M., James, R.D., 1984. Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumor marker. Brth. J. Cancer. 50, 765-769.
  • Coussy, F., Chéreau, E., Daraï, E., Dhombres, F., Lotz, J.P., Rouzier, R., Selle, F., 2011. Interest of CA 125 level in management of ovarian can- cer. Gynecol. Obstet. Fertil. 39, 296-301.
  • Donaldson, E.S., Van Nagell, J.R., Pursell, S., 1980. Multiple biochemical markers on patients with gynaecologic malignancies. Cancer. 45, 948-953.
  • Goone Wardene, T.I., 2007. Management of asymptomatic patients on follow-up for ovarian cancer with rising CA-125 concentrations. Lancet Oncol. 8, 813-821.
  • Gregory, P. Beehler., Manveen S., Julie, A. B., Barbara E. T., Susan, E. M., Kerry J. R., and Kirsten B. M., 2006. Risk of ovarian cancer associ- ated with BMI varies by menopausal status.J. Nutr. 136, 2881–2886.
  • Hogdall, E., 2008. Cancer antigen CA-125 and prognosis. Curr. Opin. Obstet. Gynecol. 20, 4-8.
  • Keys, A., Fidanza, F., Karvonen, M.J., Kimura, N., Taylor, H.L., 1972. Indices of relative weight and adiposity. J. Chronic. Dis. 25, 329-343.
  • Kramer, J.L., Greene, M.H., 2004. Epidemiology of Ovarian, Fallopian Tube, and Primary Peritoneal Cancers. in: Gynecologic Cancer: Contro- versies in Management. Gershenson, D., Gore, M., McGuire, W., Quinn, M., Thomas, G., editors. Elsevier Science. pp. 327-340.
  • Manolov, V., Marinov, B., Vasilev, V., 2012. HE4 and CA125 in ovarian cancer. Akush. Ginekol. 51, 21-28.
  • NCCN: National Comprehensive Cancer Network, 2009. NCCN Practice Guidelines in Oncology: Ovarian cancer, Vol. 2.
  • Rustin, G.J.S., Nelstrop, A.E., Bentzen, S.M., Piccart, M.J., Bertelsen, K., 1999. Use of tumour markers in monitoring the course of ovarian cancer. Ann. Oncology. 10, 21-27.
  • Rustin, G.J.S., Nelstrop, A.E., Tuxen, M.K, Lambert, H.E., 1996. Defining progression of ovarian carcinoma during follow-up according to CA-125: A North Thames Ovary Group Study. Ann. Oncology. 7, 361-364.
  • Sproston, A.R.M., Roberts, S.A., Davidson, S.E., Hunter, R.D. , West, C.M.L., 1995. Serum tumor markers in carcinoma of the uterine cervix and outcome following radiotherapy. Brith. J. Cancer. 72,1536-1540.
  • Tietz, N.W. (Ed)., 1995. Clinical guide to laboratory tests, 3rd. ed. W. B. Saunders, Philadelphia, PA .pp.
  • Yin, B.W., Lloyd, K.O., 2001. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J. Biol. Chem. 276, 27371-27375. Ali Omer et al.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Basic Medical Sciences
Authors

Mohammed Alıomer

Mohamed Mohamed This is me

Mohamed Yousef

Mohammed Farahna This is me

Adel Alghanım This is me

Publication Date July 31, 2013
Submission Date May 12, 2013
Published in Issue Year 2013

Cite

APA Alıomer, M., Mohamed, M., Yousef, M., Farahna, M., et al. (2013). Assessment of ovarian tumor marker CA-125 during radiotherapy course. Journal of Experimental and Clinical Medicine, 30(2), 137-139. https://doi.org/10.5835/jecm.omu.30.02.010
AMA Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. July 2013;30(2):137-139. doi:10.5835/jecm.omu.30.02.010
Chicago Alıomer, Mohammed, Mohamed Mohamed, Mohamed Yousef, Mohammed Farahna, and Adel Alghanım. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine 30, no. 2 (July 2013): 137-39. https://doi.org/10.5835/jecm.omu.30.02.010.
EndNote Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A (July 1, 2013) Assessment of ovarian tumor marker CA-125 during radiotherapy course. Journal of Experimental and Clinical Medicine 30 2 137–139.
IEEE M. Alıomer, M. Mohamed, M. Yousef, M. Farahna, and A. Alghanım, “Assessment of ovarian tumor marker CA-125 during radiotherapy course”, J. Exp. Clin. Med., vol. 30, no. 2, pp. 137–139, 2013, doi: 10.5835/jecm.omu.30.02.010.
ISNAD Alıomer, Mohammed et al. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine 30/2 (July 2013), 137-139. https://doi.org/10.5835/jecm.omu.30.02.010.
JAMA Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. 2013;30:137–139.
MLA Alıomer, Mohammed et al. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine, vol. 30, no. 2, 2013, pp. 137-9, doi:10.5835/jecm.omu.30.02.010.
Vancouver Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. 2013;30(2):137-9.