Mean platelet volume in diagnosis of gestational diabetes

Abstract

Gestational diabetes mellitus (GDM) prevalence is within range of 1-14%, varying relative to the countries and ethnic groups. By many studies, mean platelet volume (MPV) has been shown to be higher in GDM and Type II diabetes mellitus patients. Our aim is to evaluate the sensitivity and specificity of MPV in GDM screening. The study population was consisted of pregnant women aged above 18 years with a singleton pregnancy at 24 to 28 weeks of gestation. Three hundred patients complying with the study criteria were split into 3 groups as follows: Group 1, 219 pregnant patients with normal 50g oral glucose tolerance test (OGTT) result; Group 2, 23 pregnant patients diagnosed with impaired glucose tolerance based on the OGTT result; and Group 3, 58 pregnant patients diagnosed with GDM. MPV measurement was started with collecting 2 ml blood samples into K3 Etilendiamintetraasetikasit (EDTA) tubes from each patient. The statistical analyses were done with statistical package for the social sciences (SPSS) 20.0 package program. In our study, the optimal cut-off MPV value for GDM prediction was >8.8 fL. The specificity and negative predictive value of MPV at >8,8 fL were 75.9% and 38.9%, respectively. GDM patients may exhibit significant changes in MPV and hemoglobin A1c (HbA1c) values. Future randomized studies will be helpful in developing a MPV-related diagnostic test, adjusting the treatment, predicting the complications, and taking preventive measures in GDM patients.

Keywords

• Diagnostic test
• Gestational diabetes mellitus
• Impaired glucose tolerance
• Mean platelet volume

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