Drug transport to the brain

S.sırrı Bilge; Arzu Erdal Ağrı; Bahar Akyüz

EN

Drug transport to the brain

Abstract

Blood brain barrier (BBB) is a special cellular system that enables the nervous system to maintain in brains homeostasis by allowing the essential materials to pass while denying harmful substances. All of the drugs with high molecular weight and 98% of the drugs with low molecular weight cannot pass through the BBB. Only a few high liposoluble molecules, which have smaller than 500 Da molecular weight, can pass through the BBB. Thus, a great number of central nervous system diseases do not respond to this kind of drugs. However, in order to effectively treat a great quantity of neurological diseases there is increasing necessity for drugs which can pass through the central nervous system. In conclusion, in recent years, studies aimed new strategies for the passage of the drugs with high molecular weight through the brain have been carried out.

Keywords

Blood brain barrier,brain delivery; drug transport

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

S.sırrı Bilge

Arzu Erdal Ağrı This is me

Bahar Akyüz

Publication Date

June 16, 2016

Submission Date

November 30, 2015

Acceptance Date

-

Published in Issue

Year 2016 Volume: 33 Number: 2

IZ

https://izlik.org/JA85WD92WX

Cite

RIS / Bibtex

APA

Bilge, S., Erdal Ağrı, A., & Akyüz, B. (2016). Drug transport to the brain. Deneysel Ve Klinik Tıp Dergisi, 33(2). https://izlik.org/JA85WD92WX

AMA

1.Bilge S, Erdal Ağrı A, Akyüz B. Drug transport to the brain. J. Exp. Clin. Med. 2016;33(2). https://izlik.org/JA85WD92WX

Chicago

Bilge, S.sırrı, Arzu Erdal Ağrı, and Bahar Akyüz. 2016. “Drug Transport to the Brain”. Deneysel Ve Klinik Tıp Dergisi 33 (2). https://izlik.org/JA85WD92WX.

EndNote

Bilge S, Erdal Ağrı A, Akyüz B (June 1, 2016) Drug transport to the brain. Deneysel ve Klinik Tıp Dergisi 33 2

IEEE

[1]S. Bilge, A. Erdal Ağrı, and B. Akyüz, “Drug transport to the brain”, J. Exp. Clin. Med., vol. 33, no. 2, June 2016, [Online]. Available: https://izlik.org/JA85WD92WX

ISNAD

Bilge, S.sırrı - Erdal Ağrı, Arzu - Akyüz, Bahar. “Drug Transport to the Brain”. Deneysel ve Klinik Tıp Dergisi 33/2 (June 1, 2016). https://izlik.org/JA85WD92WX.

JAMA

1.Bilge S, Erdal Ağrı A, Akyüz B. Drug transport to the brain. J. Exp. Clin. Med. 2016;33. Available at https://izlik.org/JA85WD92WX.

MLA

Bilge, S.sırrı, et al. “Drug Transport to the Brain”. Deneysel Ve Klinik Tıp Dergisi, vol. 33, no. 2, June 2016, https://izlik.org/JA85WD92WX.

Vancouver

1.S.sırrı Bilge, Arzu Erdal Ağrı, Bahar Akyüz. Drug transport to the brain. J. Exp. Clin. Med. [Internet]. 2016 Jun. 1;33(2). Available from: https://izlik.org/JA85WD92WX