Thiol disulfide homeostasis as oxidative stress marker in migraine patients

Abstract

Migraine is a very common disease. Annual prevalence of migraine in our coun-try is reported as 16.4%. Oxidative stress is assumed to play a role in the patho-physiology of migraine. In many recent studies conducted on individuals with migraine, serum Oxidative Stress Index (OSI), Total Antioxidant Status (TAS), Total Oxidant Status (TOS) values were analyzed and it was indicated that the balance shifts towards oxidative direction. Thiol-disulfide homeostasis, which is an oxidative stress marker, was described in recent years and has been shown to have vital importance on cellular functions. In the light of this information, we aimed to examine the role of oxidative stress in pathogenesis of migraine disease with new biomarkers. The study was conducted on 36 cases of 24 pa-tients (17 female, 7 male; mean age: 40.54±11.60) followed up with a migraine diagnosis and 12 people in the healthy control group with similar age and sex (10 female, 2 male; mean age: 38.17±10.80). Total thiol (μmol/L), native thiol (μmol/L) and disulfide level, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol ratios were quantified in the patient and control groups. In the migraine group with aura, reduced ratio and thiol oxidation reduction ratio val-ues were high and oxidized thiol ratio values were low (p = 0.010, 0.015, 0.048). This study focused on thiol-disulfide hemostasis, a new and reliable indicator in determining oxidative stress which is held responsible for the pathophysiology of migraine.

Keywords

• Migraine,Aura,Oxidative Stress,Thiol disulfide

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