EN
Treatment Of Variceal Bleeding
Abstract
Cirrhosis is termed as the late stage of progressive hepatic fibrosis characterized by the disruption of the hepatic parenchymal structure and the formation of regenerative nodules. Many factors play a role in the etiology of cirrhosis. Currently, mortality is still high and causes significant work loss. The prognosis of patients with cirrhosis is largely due to its complications. Treatment of cirrhosis is limited except liver transplantation. An important cause of the morbidity and mortality associated with cirrhosis is the development of variceal bleeding secondary to portal hypertension. The prognosis of patients with variceal bleeding depends on the bleeding or other complications is associated with underlying chronic liver disease and its management. The mortality rate due to active variceal bleeding is around 20 percent during each bleeding and re-bleeding is observed in 70 percent of patients within one year. Upper gastrointestinal bleeding unrelated to portal hypertension is also common in patients with portal hypertension (eg, peptic ulcer disease). In this article, we will talk about variceal bleeding secondary to portal hypertension and its treatment based on current data.
Keywords
References
- Avgerinos A, Nevens F, Raptis S, Fevery J. Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Lancet 1997; 350:1495.
- Beppu K, Inokuchi K, Koyanagi N, et al. Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc 1981; 27:213.
- Besson I, Ingrand P, Person B, et al. Sclerotherapy with or without octreotide for acute variceal bleeding. N Engl J Med 1995; 333:555.
- Bosch J, Bordas JM, Rigau J, et al. Noninvasive measurement of the pressure of esophageal varices using an endoscopic gauge: comparison with measurements by variceal puncture in patients undergoing endoscopic sclerotherapy. Hepatology 1986; 6:667.
- Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila F, et al. Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding - an updated Cochrane review. Aliment Pharmacol Ther 2011; 34:509.
- D’Amico G, Politi F, Morabito A, et al. Octreotide compared with placebo in a treatment strategy for early rebleeding in cirrhosis. A double blind, randomized pragmatic trial. Hepatology 1998; 28:1206.
- D’amico G, Criscuoli V, Fili D, et al. Meta-analysis of trials for variceal bleeding. Hepatology 2002; 36:1023.
- D’Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology 2006; 131:1611.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Review
Publication Date
March 18, 2021
Submission Date
September 23, 2020
Acceptance Date
December 27, 2020
Published in Issue
Year 2021 Volume: 38 Number: 2s
APA
Büyükturan, G., & Sakin, Y. S. (2021). Treatment Of Variceal Bleeding. Deneysel Ve Klinik Tıp Dergisi, 38(2s), 17-22. https://izlik.org/JA29HR64MX
AMA
1.Büyükturan G, Sakin YS. Treatment Of Variceal Bleeding. J. Exp. Clin. Med. 2021;38(2s):17-22. https://izlik.org/JA29HR64MX
Chicago
Büyükturan, Galip, and Yusuf Serdar Sakin. 2021. “Treatment Of Variceal Bleeding”. Deneysel Ve Klinik Tıp Dergisi 38 (2s): 17-22. https://izlik.org/JA29HR64MX.
EndNote
Büyükturan G, Sakin YS (March 1, 2021) Treatment Of Variceal Bleeding. Deneysel ve Klinik Tıp Dergisi 38 2s 17–22.
IEEE
[1]G. Büyükturan and Y. S. Sakin, “Treatment Of Variceal Bleeding”, J. Exp. Clin. Med., vol. 38, no. 2s, pp. 17–22, Mar. 2021, [Online]. Available: https://izlik.org/JA29HR64MX
ISNAD
Büyükturan, Galip - Sakin, Yusuf Serdar. “Treatment Of Variceal Bleeding”. Deneysel ve Klinik Tıp Dergisi 38/2s (March 1, 2021): 17-22. https://izlik.org/JA29HR64MX.
JAMA
1.Büyükturan G, Sakin YS. Treatment Of Variceal Bleeding. J. Exp. Clin. Med. 2021;38:17–22.
MLA
Büyükturan, Galip, and Yusuf Serdar Sakin. “Treatment Of Variceal Bleeding”. Deneysel Ve Klinik Tıp Dergisi, vol. 38, no. 2s, Mar. 2021, pp. 17-22, https://izlik.org/JA29HR64MX.
Vancouver
1.Galip Büyükturan, Yusuf Serdar Sakin. Treatment Of Variceal Bleeding. J. Exp. Clin. Med. [Internet]. 2021 Mar. 1;38(2s):17-22. Available from: https://izlik.org/JA29HR64MX
