Research Article

Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia

Volume: 38 Number: 2 April 3, 2021
EN

Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia

Abstract

Background Iron deficiency and zinc deficiency had been known to disturb congnitive functions especially in infants and preschool children. Our purpose was to evaluate the effect of zinc deficiency and iron deficiency on cognitive function (with Montreal Cognitive Assesment [MoCA] score) in females. Methods: We designed a randomized controlled prospective study. 41 iron deficient female patients and 40 healthy volunteers were involved in the study Results: The average MoCA score ± SD was 24,63 ± 4,3 (range 11–30) in ıron deficiency anemia (IDA), and 27.43± 2.02 (23-30) in healthy volunteers. Zinc level was 97.06 (40.8–146.8) mg/dl and 257.5 (128.2–463.7) in IDA and healthy volunteers respectively. MoCA score (r= 0.803, p=0,000<0,01), were significantly correlated with Zinc Level in iron deficient group. Conclusion: We found that there was a statistically important linear relationship between MoCA score and zinc level in female patinets with iron defciency anemia.

Keywords

References

  1. Aruga, J. (2004). The role of Zic genes in neural development. Mol Cell Neurosci, 26(2), 205-221. doi: 10.1016/j.mcn.2004.01.004
  2. Bhatnagar, S., & Taneja, S. (2001). Zinc and cognitive development. Br J Nutr, 85 Suppl 2, S139-145. doi: 10.1079/bjn2000306
  3. Chowanadisai, W., Graham, D. M., Keen, C. L., Rucker, R. B., & Messerli, M. A. (2013). A zinc transporter gene required for development of the nervous system. Commun Integr Biol, 6(6), e26207. doi: 10.4161/cib.26207
  4. Cumming, T. B., Churilov, L., Linden, T., & Bernhardt, J. (2013). Montreal Cognitive Assessment and Mini-Mental State Examination are both valid cognitive tools in stroke. Acta Neurol Scand, 128(2), 122-129. doi: 10.1111/ane.12084
  5. Falkingham, M., Abdelhamid, A., Curtis, P., Fairweather-Tait, S., Dye, L., & Hooper, L. (2010). The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J, 9, 4. doi: 10.1186/1475-2891-9-4
  6. Grabrucker, S., Boeckers, T. M., & Grabrucker, A. M. (2016). Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency. Front Behav Neurosci, 10, 37. doi: 10.3389/fnbeh.2016.00037
  7. Hershko, C., & Camaschella, C. (2014). How I treat unexplained refractory iron deficiency anemia. Blood, 123(3), 326-333. doi: 10.1182/blood-2013-10-512624
  8. Jiang, Y. G., Fang, H. Y., Pang, W., Liu, J., Lu, H., Ma, Q., & Fang, H. T. (2011). Depressed hippocampal MEK/ERK phosphorylation correlates with impaired cognitive and synaptic function in zinc-deficient rats. Nutr Neurosci, 14(2), 45-50. doi: 10.1179/1476830510Y.0000000002

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Publication Date

April 3, 2021

Submission Date

November 7, 2020

Acceptance Date

November 11, 2020

Published in Issue

Year 2021 Volume: 38 Number: 2

APA
Alayvaz Aslan, N., Kelkitli, E., & Öztürk, N. (2021). Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. Deneysel Ve Klinik Tıp Dergisi, 38(2), 111-114. https://izlik.org/JA58AM22PH
AMA
1.Alayvaz Aslan N, Kelkitli E, Öztürk N. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. 2021;38(2):111-114. https://izlik.org/JA58AM22PH
Chicago
Alayvaz Aslan, Nevin, Engin Kelkitli, and Nurinnisa Öztürk. 2021. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Deneysel Ve Klinik Tıp Dergisi 38 (2): 111-14. https://izlik.org/JA58AM22PH.
EndNote
Alayvaz Aslan N, Kelkitli E, Öztürk N (April 1, 2021) Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. Deneysel ve Klinik Tıp Dergisi 38 2 111–114.
IEEE
[1]N. Alayvaz Aslan, E. Kelkitli, and N. Öztürk, “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”, J. Exp. Clin. Med., vol. 38, no. 2, pp. 111–114, Apr. 2021, [Online]. Available: https://izlik.org/JA58AM22PH
ISNAD
Alayvaz Aslan, Nevin - Kelkitli, Engin - Öztürk, Nurinnisa. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Deneysel ve Klinik Tıp Dergisi 38/2 (April 1, 2021): 111-114. https://izlik.org/JA58AM22PH.
JAMA
1.Alayvaz Aslan N, Kelkitli E, Öztürk N. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. 2021;38:111–114.
MLA
Alayvaz Aslan, Nevin, et al. “Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia”. Deneysel Ve Klinik Tıp Dergisi, vol. 38, no. 2, Apr. 2021, pp. 111-4, https://izlik.org/JA58AM22PH.
Vancouver
1.Nevin Alayvaz Aslan, Engin Kelkitli, Nurinnisa Öztürk. Effect Of Zinc Deficiency On Cognitive Function in Females With Iron Deficiency Anemia. J. Exp. Clin. Med. [Internet]. 2021 Apr. 1;38(2):111-4. Available from: https://izlik.org/JA58AM22PH