The Effects Of Nimodipine, Tyrotyropine Releasing Hormon (TRH) And Gingkgo Biloba Extract (GBB) İn Experimental Spinal Cord Injuries
Abstract
There have been interest in the role of some drugs in the pathohysiology of spinal cord in¬jury. In the present study we have evaluated the effects of treatment with nimodipine, TRH, GBE on functional recorvery and histopatological changes when these drugs are administered after spinal cord trauma in the anesthetized rabbits. 50 rabbits were divided in five treatment groups. Group 1 (10 Rabbits) received nimodipine (500 p:g/kg/day intraperitoneally) during first 7 days. Group 2 (10 Rabbits) receivied TRH (2,5 |ig/kg/day intraperitoneally) during first 7 day. Group 3 (10 Rabbits) received GBE (1 mgr/kg/day intra-peritoneally) during first 7 day. Group 4 (10 Rabbits) received nimodipine, TRH, GBE at the same time, during the first 7 days. Group 5(10 Rabbits) received no drug after spinal cord injury. There was no significant clinical and histopatological differences scores among the three treatment groups (Group 1, 2, 3) whereas Group 4 had better clinical scores than other groups.
Deneysel Spinal Kord Yaralanmalarında Nimodipine, TRH ve Gingkgo Biloba Ekstresinin Etkileri
%/ Spinal kord yaralanmalarının flzyopatolojisinde birçok ilacın önemli rolleri vardır. Bu çalışmada, anestezi altındaki tavşanlara spinal kord travması yaptıktan sonra Nimodipine, TRH ve Ginkgo Biloba Ekstresi (GBE) verilerek, bu ilaçların fonksiyonel iyileşme ve histo-patolojik değişiklikler üzerine etkileri araştırıldı. Toplam 50 tavşan beş gruba ayrıldı. 1.Gruba (10 tavşan) 500 jig/kg/7 gün süreyle Nimodipine intraperitoneal olarak verildi. 2.Gruba (10 tavşan) 2,5 |ig/kg/gün TRH intraperitoneal olarak verildi. 3. Gruba (10 tavşan) 1 mgr/kg/7 gün intraperitoneal olarak GBE verildi. 4. Gruba (10 tavşan) Nimodipine, TRH ve GBE aynı anda verildi. 5. Gruba (10 tavşan) hiçbir ilaç verilmedi. İlk üç grup arasında önemli bir klinik ve histopatolojik fark yoktu. 4. Grup klinik olarak diğerlerinden daha iyi idi.
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| Primary Language | English |
|---|---|
| Journal Section | Basic Medical Sciences |
| Authors | |
| Publication Date | December 22, 2009 |
| Submission Date | December 4, 2009 |
| Published in Issue | Year 1994 Volume: 11 Issue: 2 |
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