Abstract
Subacute Thyroiditis in a Patient with Chronic Hepatitis C During Interferon Treatment: A Case Report
Recombinant human interferon alpha (r-IFN-alpha) is often successfully used in the treatment of patients with chronic viral hepatitis. The interferons are a groups of proteins with antiviral, anti-proliferative and immunomodulatory effects. Because of their broad activity, interferons have many side effects. Several investigators have reported the development of autoimmune diseases particularly thyroid disease during interferon therapy. The patient, 39 years old woman was diagnosed of chronic hepatitis C and began to take interferon treatment. On the 6th month of treatment, she was admitted to our clinic because of weakness, lack of appetite palpitation and weight loss for two weeks. The diagnosed of subacute thyroiditis was made by physical and laboratory findings. Interferon therapy was stopped and beta blocker was given. Signs were disappeared within 7 weeks and thyroid hormones became normal. One should keep in mind that the side effects of interferon therapy like weakness, losing weight, palpitation could be the sign and symptoms of a developed hyperthyroidism as well.
Rekombinant interferon-a kronik viral hepatitlerin tedavisinde basan ile kullanılmaktadır. İnterferonlar antiviral, antiproliferatif ve immünmodülatör etki göstermektedir. Bu geniş etki spektrumlanndan dolayı birçok yan etkileri vardır. Tedavi sırasında, özellikle daha önceden otoimmun tiroid hastalığı olanlarda hipotiroidizm, hipertiroidizm ve tiroidit geliştiği bildirilmiştir. Kronik hepatit C tanısıyla izlenen altı aydır interferon-a tedavisi alan 39 yaşındaki bayan hasta son iki haftadır devam eden halsizlik, iştahsızlık, çarpıntı, kilo kaybı şikayetleri ile kliniğimize başvurdu. Fizik muayene ve laboratuvar bulgularla hastaya subakut tiroidit tanısı kondu. Interferon tedavisi kesildikten sonra beta bloker verilerek izlenen hastanın şikayetleri ve klinik bulguları 7 hafta içinde kayboldu, tiroid hormon değerleri normale döndü. İnterferonun yan etkileri olarak görülebilen halsizlik, kilo kaybı, çarpma gibi klinik belirtilerin aynı zamanda bazı tiroid hastalıklarının seyrinde de görülebileceği akılda tutulmalıdır.
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| Primary Language | English |
|---|---|
| Journal Section | Basic Medical Sciences |
| Authors | |
| Publication Date | December 23, 2009 |
| Submission Date | December 18, 2009 |
| Published in Issue | Year 1999 Volume: 16 Issue: 1 |
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