Maternal Vitamin B12 Eksikliğinin Neden Olduğu Nörolojik Bulgularda Bilinmeyen Faktörlerin Rolü Olabilir mi?:Olgu Sunumu
Öz
Vitamin B12, hücre siklusunda önemli görevleri olan, DNA sentezinde gerekli, sinir sisteminde myelin ve lipid metabolizmasında rol oynayan bir vitamindir. Vitamin B12 eksikliğine bağlı süt çocuğunun nütrisyonel megaloblastik anemisi anneye veya çocuğa bağlı nedenlerle oluşabilir. Burada değişik nörolojik bulguları olan megaloblastik anemili 3 süt çocuğu sunulmuştur. Değişik nörolojik semptom ve bulgularla başvurabilen vitamin B12 eksikliği olgularında vitamin B12'nin ne kadar süre ile ve ne seviyede düşük olmasının nörolojik bulgulara yol açtığı sorusu yanıtsızdır. Biz süt çocukluğu döneminde maternal, bebeğe bağlı nut-risyonel ve/veya bu iki nedenin birlikteliği ile ortaya çıkan 3 megaloblastik anemili süt çocuğunda, megaloblastik anemi ve beraberinde ortaya çıkabilen nörolojik bulguları vurgulamayı hedefledik. Üç süt çocuğunda da vitamin B12 düşüklüğünün derecesinden bağımsız nörolojik bulgular gözlemledik ve sonuçta megaloblastik anemi ile nörolojik bulgular arasındaki ilişkiyi netleştiren hayvan deneylerine ihtiyaç olduğu kanısına vardık.
Are There Unknown Factors Which Play a Part in Neurologic Findings Caused by Maternal Vitamin B12 Beficiency
Vitamin B12 has important functions in cell cycle and it is essential for DNA synthesis and it plays a part in myelinisation and lipid metabolism of nervous system. Infantile nutritional megaloblastic anemia occurs due to both maternal and infantile causes. In here we presented three infants with megaloblastic anemia and who have different neurologic findings. Vitamin B12 deficiency causes different signs and symptoms but, the question that how much depth and length of vitamin B12 deficiency causes neurologic findings is not answered. We presented three infants with megaloblastic anemia caused by maternal and/or infantile causes and we want to emphasize neurologic manifestations. We observed that neurologic signs are independent from VB12 level. In a conclusion further animal experiments which explain the correlation between megaloblastic anemia and neurologic manifestations are needed.
Anahtar Kelimeler
Kaynakça
- Wighton MC, Manson JI, Speed I, et al. Brain damage in infancy and dietary vitamin B deficiency. Med J Aust 1979; 2: 1–3.
- Monagle PT, Tauro GP. Infantile megaloblastosis sec- ondary to maternal vitamin B deficiency. Clin Lab Haematol 1997; 19: 23–25.
- Wadia RS, Bandishti S, Kharche M. B and folate deficiency in infancy: three case reports and a review of the literature. Pediatr Hematol Oncol ; 6: 161–172. Kalayci O, Cetin M, Kirel B, et al. Neurologic findings of vitamin B deficiency: presentation of 7 cases. Turk J Pediatr 1996; 38: 67–72.
- Wetherilt H, Ackurt F, Brubacher G, et al. Blood vita- min and mineral levels in 7–17 years old Turkish chil- dren. Int J Vitam Nutr Res 1992; 62: 21–29.
- Muhammad R, Fernhoff P, Rasmussen S, et al. Neurologic impairment in children associated with maternal dietary deficiency of cobalamin–Georgia, MMWR Morb Mortal Wkly Rep 2003; 52: –64.
- Shorvon SD, Carney MW, Chanarin I, et al. The neu- ropsychiatry of megaloblastic anaemia. Br Med J ; 281: 1036–1038.
- Garewal G, Narang A, Das KC. Infantile tremor syn- drome: A Vitamin B deficiency syndrome in infants. Journal of tropical Pediatrics 1988; 34: 174–178.
- Arya LS, Singh M, Aram GN et al. Infantile tremor syndrome. Indian J Pediatr 1988; 55: 913–917.
- Lovblad KO, Baumgartner RW, Zambaz BD, et al. Nontraumatic spinal epidural hematomas. MR fea- tures. Acta Radiol 1997; 38: 8–13.
- Von Schenck U, Bender–Gotze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B– deficiency in infancy. Arch Dis Child 1997; 77: 137–139.
- Weiss R, Fogelman Y, Bennet M. Severe vitamin B deficiency in an infant associated with a maternal deficiency and a strict vegetarian diet. J Pediatr Hematol Oncol 2004; 26: 270–271.
Öz
Kaynakça
- Wighton MC, Manson JI, Speed I, et al. Brain damage in infancy and dietary vitamin B deficiency. Med J Aust 1979; 2: 1–3.
- Monagle PT, Tauro GP. Infantile megaloblastosis sec- ondary to maternal vitamin B deficiency. Clin Lab Haematol 1997; 19: 23–25.
- Wadia RS, Bandishti S, Kharche M. B and folate deficiency in infancy: three case reports and a review of the literature. Pediatr Hematol Oncol ; 6: 161–172. Kalayci O, Cetin M, Kirel B, et al. Neurologic findings of vitamin B deficiency: presentation of 7 cases. Turk J Pediatr 1996; 38: 67–72.
- Wetherilt H, Ackurt F, Brubacher G, et al. Blood vita- min and mineral levels in 7–17 years old Turkish chil- dren. Int J Vitam Nutr Res 1992; 62: 21–29.
- Muhammad R, Fernhoff P, Rasmussen S, et al. Neurologic impairment in children associated with maternal dietary deficiency of cobalamin–Georgia, MMWR Morb Mortal Wkly Rep 2003; 52: –64.
- Shorvon SD, Carney MW, Chanarin I, et al. The neu- ropsychiatry of megaloblastic anaemia. Br Med J ; 281: 1036–1038.
- Garewal G, Narang A, Das KC. Infantile tremor syn- drome: A Vitamin B deficiency syndrome in infants. Journal of tropical Pediatrics 1988; 34: 174–178.
- Arya LS, Singh M, Aram GN et al. Infantile tremor syndrome. Indian J Pediatr 1988; 55: 913–917.
- Lovblad KO, Baumgartner RW, Zambaz BD, et al. Nontraumatic spinal epidural hematomas. MR fea- tures. Acta Radiol 1997; 38: 8–13.
- Von Schenck U, Bender–Gotze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B– deficiency in infancy. Arch Dis Child 1997; 77: 137–139.
- Weiss R, Fogelman Y, Bennet M. Severe vitamin B deficiency in an infant associated with a maternal deficiency and a strict vegetarian diet. J Pediatr Hematol Oncol 2004; 26: 270–271.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Basic Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2009 |
| Gönderilme Tarihi | 28 Ekim 2009 |
| Yayımlandığı Sayı | Yıl 2005 Cilt: 22 Sayı: 1 |
Kaynak Göster
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