Öz
Miyelopati, radyoterapinin ender görülen bir komplikasyonudur. Radyasyon miyelopatisi, iyonizan radyasyon ile karşılaşıldıktan belli bir süre sonra spinal kordun beyaz cevher hasarı ile gelişir. Radyasyon dozu, uygulamalar arasındaki süre veya lineer enerji transferi gibi bazı faktörler miyelopatinin oluşumunu ve şiddetini etkiler. Bu olgu sunumunda, mide adenokarsinomu tanısıyla yapılan operasyondan sonra kemoterapi ve radyoterapi uygulanan 56 yaşındaki erkek hastada, iki ay sonra gelişen ilerleyici paraparezi bildirilmektedir.Bu olgu, radyoterapi tedavisi sonrası nörolojik disfonksiyon gelişen hastalara örnektir.
Radiation Myelopathy: Case Report
Myelopathy is an uncommon complication of radiotherapy. Radiation myelopathy is principally a white matter injury of the spinal cord induced by ionizing radiation after a certain latent period. Several factors, such as radiation dose, fractination or linear energy transfer, modify its occurrence and severity. A 56-year old man with gastric adenocarcinoma underwent chemotherapy and radiotherapy following tumor excision. Two months later he developed a progressive paraparesis. This case is a model for the patiens that develops neurologic dysfunction after radiotherapy.
Anahtar Kelimeler
Kaynakça
- Antunes NL, Wolden S, Souweidane MM et al. Radiation myelitis in a 5–year–old girl. J Child Neurol 2002 Mar; 17: 217–219.
- Maranzano E, Bellavita R, Floridi P et al. Radiation–induced myelopathy in long–term surviving metastatic spinal cord compression patients after hypofractionated radiotherapy: a clinical and magnetic resonance imaging analysis. Radiother Oncol 2001 Sep; 60: 281–288.
- Okada S, Okeda R. Pathology of radiation myelopathy. Neuropathology 2001 Dec; 21: 247–265.
- Micheal WT,Andrew W, Gail R et al. Radiation myelopathy following transplantation and radioterapy for Non–Hoodgkin’s Lymphoma. Int .J. Radiation Oncology 1998 Mar; 41: 1057–1061.
- Toshihiro Y, Hisatoshi Y, Masaki K et al. Significance of gadolinium–enchanced magnetic resonance imaging in differentiating spinal cord radiation myelopathy from tumor: case report. J Neurosurg 1992 Oct; 77: 628–631.
- Richard HF, Richard DM, Keene MW. Chronic Radiation Myelitis. Radiology 1982 Aug; 144: 609–612.
- Philips TL, Buschke F. Radiation tolerance of the tho- racic spinal cord. AJR 1969; 105: 659–664.
Öz
Kaynakça
- Antunes NL, Wolden S, Souweidane MM et al. Radiation myelitis in a 5–year–old girl. J Child Neurol 2002 Mar; 17: 217–219.
- Maranzano E, Bellavita R, Floridi P et al. Radiation–induced myelopathy in long–term surviving metastatic spinal cord compression patients after hypofractionated radiotherapy: a clinical and magnetic resonance imaging analysis. Radiother Oncol 2001 Sep; 60: 281–288.
- Okada S, Okeda R. Pathology of radiation myelopathy. Neuropathology 2001 Dec; 21: 247–265.
- Micheal WT,Andrew W, Gail R et al. Radiation myelopathy following transplantation and radioterapy for Non–Hoodgkin’s Lymphoma. Int .J. Radiation Oncology 1998 Mar; 41: 1057–1061.
- Toshihiro Y, Hisatoshi Y, Masaki K et al. Significance of gadolinium–enchanced magnetic resonance imaging in differentiating spinal cord radiation myelopathy from tumor: case report. J Neurosurg 1992 Oct; 77: 628–631.
- Richard HF, Richard DM, Keene MW. Chronic Radiation Myelitis. Radiology 1982 Aug; 144: 609–612.
- Philips TL, Buschke F. Radiation tolerance of the tho- racic spinal cord. AJR 1969; 105: 659–664.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Basic Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2009 |
| Gönderilme Tarihi | 28 Ekim 2009 |
| Yayımlandığı Sayı | Yıl 2005 Cilt: 22 Sayı: 1 |
Kaynak Göster
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