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Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları

Yıl 2007, Cilt: 24 Sayı: 2, 62 - 66, 29.12.2009

Öz

Angioinvasive Pulmonary Aspergillosis: CT and MRI Findings
Pulmonary aspergillosis is rare but potentially fatal infectious disease which is seen in immune compromised patients. Most of the cases are seen in patients who used chemotheraphy for hematological malignancies, bone marrow or solid organ transplant patients, patients with primer immune deficiency. The patient's immune system and the morphological changes in lungs determine course of infection. Angioinvasive pulmonary aspergillosis (invasive pulmonary aspergillosis) is usually seen in patients with neutropenia and late diagnosis can be fatal. With this case we discussed the radiological findings and the course of rapid growing pulmonary aspergillosis in a 5 year old patient with acute lymphoblastic leuchemia who applied with neutropenia, cough and high fever. Magnetic resonance imaging findings done to avoid the harmful affects of radiation because of lung roentgenograms and computerized tomography were also discussed.


Pulmoner aspergillozis immün sistemi baskılanmış hastalarda nadir, fakat potansiyel olarak fatal bir enfeksiyondur. Vakaların çoğunluğu hematolojik malignensiler nedeniyle kemotera-pi alan hastalar, kemik iliği veya solid organ transplantasyonu yapılan hastalar ve primer immün yetmezliği bulunan çocuklardır. Enfeksiyon tablosu hastanın immün sisteminin durumuna yada tutulan akciğerlerdeki yapısal değişiklilere bağlıdır. Anjioinvazif aspergillozis (invazif pulmoner aspergillozis) genellikle ciddi nötropenili hastalarda ortaya çıkan, tanısı gecikirse mortalitesi yüksek bir durumdur.
Öksürük ve ateş yüksekliği şikayeti nedeniyle baş vuran ve akut lenfoblastik lösemi nedeniyle takip edilen ciddi nötropenili 5 yaşındaki çocuk hastada, hızlı gelişen anjioinvasif as-pergillozisin radyolojik bulguları ve seyri tartışılmıştır. Ayrıca takipte sık akciğer grafisi ile bilgisayarlı tomografi ye bağlı radyasyon alımını azaltmak amacıyla değişik zamanlarda yapılan manyetik rezonans görüntüleme bulguları da literatürün ışığında tartışılmıştır.

Kaynakça

  • Gerson SL, Talbot GH, Hurwitz S,et al. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med. 1984; 100: 345–351.
  • Thomas KE, Owens CM, Veys PA, et al. The radiological spectrum of invasive aspergillosis in children: a 10- year review. Pediatr Radiol. 2003; 33: 453–460.
  • Yildirim N, Topal U. Pulmonary aspergillosis: variable appearances (pictorial essay) Tani Girisim Radyol. 2004; 10: 121–126.
  • Worthy SA, Flint JD, Muller NL. Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings. Radiographics. 1997; 17: 1359–1371.
  • Kim SY, Lee KS, Han J, et al. Semiinvasive pulmonary aspergillosis: CT and pathologic findings in six patients. AJR Am J Roentgenol. 2000; 174: 795–798. 6. Yildirim N, Topal U. Pulmonary aspergillosis: variable appearances (pictorial essay)] Tani Girisim Radyol. 2004; 10: 121–126.
  • Franquet T, Muller NL, Gimenez A, et al. Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 2001; 21: 825–837.
  • Reichenberger F, Habicht JM, Gratwohl A, et al. Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients. Eur Respir J. 2002; 19: 743–755.
  • Yeghen T, Kibbler CC, Prentice HG, et al. Management of invasive pulmonary aspergillosis in hematology patients: a review of 87 consecutive cases at a single institution. Clin Infect Dis. 2000; 31: 859–868.
  • Caillot D, Couaillier JF, Bernard A, et al. Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic c o m p u t e d tomography scans in patients with n e u t r o p e n i a . J Clin Oncol. 2001; 19: 253–259.
  • Blum U, Windfuhr M, Buitrago-Tellez C, et al. Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest. 1994; 106: 1156–1161.
Yıl 2007, Cilt: 24 Sayı: 2, 62 - 66, 29.12.2009

Öz

Kaynakça

  • Gerson SL, Talbot GH, Hurwitz S,et al. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med. 1984; 100: 345–351.
  • Thomas KE, Owens CM, Veys PA, et al. The radiological spectrum of invasive aspergillosis in children: a 10- year review. Pediatr Radiol. 2003; 33: 453–460.
  • Yildirim N, Topal U. Pulmonary aspergillosis: variable appearances (pictorial essay) Tani Girisim Radyol. 2004; 10: 121–126.
  • Worthy SA, Flint JD, Muller NL. Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings. Radiographics. 1997; 17: 1359–1371.
  • Kim SY, Lee KS, Han J, et al. Semiinvasive pulmonary aspergillosis: CT and pathologic findings in six patients. AJR Am J Roentgenol. 2000; 174: 795–798. 6. Yildirim N, Topal U. Pulmonary aspergillosis: variable appearances (pictorial essay)] Tani Girisim Radyol. 2004; 10: 121–126.
  • Franquet T, Muller NL, Gimenez A, et al. Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 2001; 21: 825–837.
  • Reichenberger F, Habicht JM, Gratwohl A, et al. Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients. Eur Respir J. 2002; 19: 743–755.
  • Yeghen T, Kibbler CC, Prentice HG, et al. Management of invasive pulmonary aspergillosis in hematology patients: a review of 87 consecutive cases at a single institution. Clin Infect Dis. 2000; 31: 859–868.
  • Caillot D, Couaillier JF, Bernard A, et al. Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic c o m p u t e d tomography scans in patients with n e u t r o p e n i a . J Clin Oncol. 2001; 19: 253–259.
  • Blum U, Windfuhr M, Buitrago-Tellez C, et al. Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest. 1994; 106: 1156–1161.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Basic Medical Sciences
Yazarlar

M. Elmalı Bu kişi benim

K. Bayrak Bu kişi benim

M.S. Nural Bu kişi benim

M. Ceyhan Bu kişi benim

Yayımlanma Tarihi 29 Aralık 2009
Gönderilme Tarihi 16 Ekim 2009
Yayımlandığı Sayı Yıl 2007 Cilt: 24 Sayı: 2

Kaynak Göster

APA Elmalı, M., Bayrak, K., Nural, M., Ceyhan, M. (2009). Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları. Journal of Experimental and Clinical Medicine, 24(2), 62-66. https://doi.org/10.5835/jecm.v24i2.19
AMA Elmalı M, Bayrak K, Nural M, Ceyhan M. Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları. J. Exp. Clin. Med. Aralık 2009;24(2):62-66. doi:10.5835/jecm.v24i2.19
Chicago Elmalı, M., K. Bayrak, M.S. Nural, ve M. Ceyhan. “Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları”. Journal of Experimental and Clinical Medicine 24, sy. 2 (Aralık 2009): 62-66. https://doi.org/10.5835/jecm.v24i2.19.
EndNote Elmalı M, Bayrak K, Nural M, Ceyhan M (01 Aralık 2009) Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları. Journal of Experimental and Clinical Medicine 24 2 62–66.
IEEE M. Elmalı, K. Bayrak, M. Nural, ve M. Ceyhan, “Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları”, J. Exp. Clin. Med., c. 24, sy. 2, ss. 62–66, 2009, doi: 10.5835/jecm.v24i2.19.
ISNAD Elmalı, M. vd. “Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları”. Journal of Experimental and Clinical Medicine 24/2 (Aralık 2009), 62-66. https://doi.org/10.5835/jecm.v24i2.19.
JAMA Elmalı M, Bayrak K, Nural M, Ceyhan M. Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları. J. Exp. Clin. Med. 2009;24:62–66.
MLA Elmalı, M. vd. “Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları”. Journal of Experimental and Clinical Medicine, c. 24, sy. 2, 2009, ss. 62-66, doi:10.5835/jecm.v24i2.19.
Vancouver Elmalı M, Bayrak K, Nural M, Ceyhan M. Olgu Bildirisi: Anjioinvazif Pulmoner Aspergillozis, BT VE MRG Bulguları. J. Exp. Clin. Med. 2009;24(2):62-6.