Öz
Overin malign müllerian mikst tümörü (karsinosarkom) karsinomatöz ve sarkomatöz komponentleri birlikte içeren nadir görülen agresif seyirli bir tümördür. Tüm over tümörleri içinde %1’den daha az oranda izlenir ve olguların önemli bir kısmı düşük pariteye sahip postmenapozal kadınlardır. Yazımızda histopatolojik ve immünohistokimyasal bulguları ile overin malign müllerian mikst tümörü olarak değerlendirilen iki olgu nadir görülmesi nedeniyle sunuldu ve literatür ışığında tartışıldı.
Anahtar kelimeler: Malign müllerian mikst tümör, karsinosarkom, over
Malignant Mixed Mullerian Tumor of The Ovary: Two Cases Report
Malignant mixed mullerian tumor (carcinosarcoma) of the ovary is a rare, highly aggressive neoplasm that is characterized by the presence of both carcinomatous and sarcomatous components. It accounts for less than 1% of all ovarian tumors and tend to occur in low parity postmenopausal women. In this report, histopathological and immunohistochemically findings of two cases of malignant mixed mullerian tumor that is presented because of its rarity and discussed in the light of literature.
Key words: Malignant mixed mullerian tumor, carcinosarcoma, ovary
Anahtar Kelimeler
Kaynakça
- Lee KR, Tavassoli FA, Prat J, et al. Tumours of the Ovary and Peritoneum. In: Tavassoli FA, Devilee P (ed.). Pathology and Genetics Tumours of the Breast and Female Genital Organ. Lyon, IARC Press, 2003, 113–202. 2. Harris MA, Delap LM, Sengupta PS, et al. Carcinosarcoma of the ovary. Br J Cancer 2003; 88: 654–657. 3. Seidman JD, Russell P, Kurman RJ. Surface Epithelial Tumors of the Ovary. In: Kurman RJ (ed.). Blaustein’s Pathology of the Female Genital Tract (Fifth ed.). New York, Springer, 2001; 791–904.
- Barakat RR, Rubin SC, Wong G, et al. Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases. Obstet Gynecol 1992; 80: 660–664. 5. Ariyoshi K, Kawauchi S, Kaku T, et al. Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. Histopathology 2000; 37: 427–436.
- Zorzou MP, Markaki S, Rodolakis A, et al. Clinicopathological features of ovarian carcinosarcomas: a single institution experience. Gynecol Oncol 2005; 96: 136–142.
- Chang J, Sharpe JC, A’Hern RP, et al. Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients. Ann Oncol 1995; 6: 755–758.
- Brown E, Stewart M, Rye T, et al. Carcinosarcoma of the ovary: 19 years of prospective data from a single center. Cancer 2004; 100: 2148–2154.
- Sit AS, Price FV, Kelley JL, et al. Chemotherapy for malignant mixed Müllerian tumors of the ovary. Gynecol Oncol 2000; 79: 196–200.
- Hellstrom AC, Tegerstedt G, Silfversward C, et al. Malignant mixed müllerian tumors of the ovary: histopathologic and clinical review of 36 cases. Int J Gynecol Cancer 1999; 9: 312–316.
- Rosai J. Rosai and Ackerman’s Surgical Pathology. Ninth Edition, Volume 2, London, Mosby, 2004, 1649–1736.
- Tanimoto A, Arima N, Hayashi R, et al. Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differantiation. Pathol Int 2002; 51:829–832.
Öz
Kaynakça
- Lee KR, Tavassoli FA, Prat J, et al. Tumours of the Ovary and Peritoneum. In: Tavassoli FA, Devilee P (ed.). Pathology and Genetics Tumours of the Breast and Female Genital Organ. Lyon, IARC Press, 2003, 113–202. 2. Harris MA, Delap LM, Sengupta PS, et al. Carcinosarcoma of the ovary. Br J Cancer 2003; 88: 654–657. 3. Seidman JD, Russell P, Kurman RJ. Surface Epithelial Tumors of the Ovary. In: Kurman RJ (ed.). Blaustein’s Pathology of the Female Genital Tract (Fifth ed.). New York, Springer, 2001; 791–904.
- Barakat RR, Rubin SC, Wong G, et al. Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases. Obstet Gynecol 1992; 80: 660–664. 5. Ariyoshi K, Kawauchi S, Kaku T, et al. Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. Histopathology 2000; 37: 427–436.
- Zorzou MP, Markaki S, Rodolakis A, et al. Clinicopathological features of ovarian carcinosarcomas: a single institution experience. Gynecol Oncol 2005; 96: 136–142.
- Chang J, Sharpe JC, A’Hern RP, et al. Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients. Ann Oncol 1995; 6: 755–758.
- Brown E, Stewart M, Rye T, et al. Carcinosarcoma of the ovary: 19 years of prospective data from a single center. Cancer 2004; 100: 2148–2154.
- Sit AS, Price FV, Kelley JL, et al. Chemotherapy for malignant mixed Müllerian tumors of the ovary. Gynecol Oncol 2000; 79: 196–200.
- Hellstrom AC, Tegerstedt G, Silfversward C, et al. Malignant mixed müllerian tumors of the ovary: histopathologic and clinical review of 36 cases. Int J Gynecol Cancer 1999; 9: 312–316.
- Rosai J. Rosai and Ackerman’s Surgical Pathology. Ninth Edition, Volume 2, London, Mosby, 2004, 1649–1736.
- Tanimoto A, Arima N, Hayashi R, et al. Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differantiation. Pathol Int 2002; 51:829–832.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Surgery Medical Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Aralık 2009 |
| Gönderilme Tarihi | 25 Aralık 2009 |
| Yayımlandığı Sayı | Yıl 2008 Cilt: 25 Sayı: 4 |
Kaynak Göster
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