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Effect of lemon juice on blood pressure

Year 2012, Volume: 29 Issue: 1, 38 - 41, 17.04.2012
https://doi.org/10.5835/jecm.omu.29.01.010

Abstract

Lemon juice has commonly been used by hypertensive patients in order to lower blood pressure (BP) acutely when BP is raised or as an alternative/complementary therapy for expectation of chronic improvement. Grapefruit, a citrus fruit like lemon, causes clinically significant interactions with a variety of drugs including calcium antagonists. The aims of this study were to investigate acute and chronic effects of lemon juice on BP among hypertensive patients. Ninty-eight patients were included in this prospective study. Patients using calcium antagonists were not included in the study. In the acute study group, neither lemon juice nor water affected systolic and diastolic BPs. Blood pressure readings after two weeks of lemon juice were not different when compared to basal measurements. There is little information about drinking lemon juice in hypertensive patients. To our knowledge, acute or chronic effect of lemon juice on BP has not been investigated previously. This study did not show any beneficial effects of lemon juice on elevated BP. Besides, lemon juice has two potential risks for the users; drug interaction and noncompliance to the prescribed treatment. In conclusion, there is no evidence that lemon juice lowers BP at the present time and more studies are needed to investigate the effect of lemon juice on BP and possible interactions between lemon juice and drugs. Physicians should keep in mind that alternative therapies can have risks and train their patients about compliance to the treatment. 

References

  • Adibelli, Z., Dilek, M., Akpolat, T., 2009. Lemon juice as an alternative therapy in hypertension in Turkey. Int. J. Cardiol. 135, 58-59.
  • Altun, B., Arici, M., Nergizoğlu, G., Derici, U., Karatan, O., Turgan, C., Sindel, S., Erbay, B., Hasanoğlu, E., Cağlar, S., 2005. Prevalence, aware- ness, treatment and control of hypertension in Turkey (the PatenT study) in 2003. J. Hypertens. 23, 1817-1823.
  • Bailey, D.G., Dresser, G.K., Bend, J.R., 2003. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin. Pharmacol. Ther. 73, 529-537.
  • Bailey, D.G., Dresser, G.K., 2004. Interactions between grapefruit juice and cardiovascular drugs. Am. J. Cardiovasc. Drugs. 4, 281-297.
  • Betancourt, J.R., Carrillo, J.E., Gren, A.R., 1999. Hypertension in multicultural and minority populations: linking communication to compliance. Curr. Hypertens. Rep. 1, 482-488.
  • Capraz, M., Dilek, M., Akpolat, T., 2007. Garlic, hypertension and patient education. Int. J. Cardiol. 121, 130-131.
  • Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo, J.L. Jr., Jones, D.W., Materson, B.J., Oparil, S., Wright, J.T. Jr., Roccella, E.J.,2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 42, 1206-1252.
  • Díaz-Juárez, J.A., Tenorio-López, F.A., Zarco-Olvera, G., Valle-Mondragón, L.D., Torres-Narváez, J.C., Pastelín-Hernández, G., 2009. Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo. Phytother. Res. 23, 948-954.
  • Edwards, R.L., Lyon, T., Litwin, S.E., Rabovsky, A., Symons, J.D., Jalili, T., 2007. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 137, 2405-2411.
  • González-Molina, E., Domínguez-Perles, R., Moreno, D.A., García-Viguera, C., 2010. Natural bioactive compounds of Citrus limon for food and health. J. Pharm. Biomed. Anal. 51, 327-345.
  • Lilja, J.J., Raaska, K., Neuvonen P.J., 2005. Effects of orange juice on the pharmacokinetics of atenolol. Eur. J. Clin. Pharmacol. 61, 337-340.
  • Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A.M., Kjeldsen, S.E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynkiewicz, A., Schmieder, R.E., Boudier, H.A., Zanchetti, A., Vahanian, A., Camm, J., De Caterina, R., Dean,V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S.D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J.L., Erdine, S., Kiowski, W., Agabiti-Rosei, E., Ambrosioni, E., Lindholm, L.H., Viigimaa, M., Adamopoulos, S., Agabiti-Rosei, E., Ambrosioni, E., Bertomeu, V., Clement, D., Erdine, S., Farsang, C., Gaita, D., Lip, G., Mallion, J.M., Manolis, A.J., Nilsson, P.M., O'Brien, E., Ponikowski, P., Redon, J., Ruschitzka, F., Tamargo, J., van Zwieten, P., Waeber, B., Williams, B., 2007. Manage-ment of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 25, 1105-1187.
  • Perez-Vizcaino, F., Duarte, J., Jimenez, R., Santos-Buelga, C., Osuna, A., 2009. Antihypertensive effects of the flavonoid quercetin. Pharmacol. Rep. 61, 67-75.
  • Reshef, N., Hayari, Y., Goren, C., Boaz, M., Madar, Z., Knobler, H., 2005. Antihypertensive effect of sweetie fruit in patients with stage I hyper- tension. Am J. Hypertens. 18, 1360-1363.
  • Saito, M., Hirata-Koizumi, M., Matsumoto, M., Urano, T., Hasegawa, R., 2005. Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies. Drug Saf. 28, 677-694.
  • Toprak, D., Demir, S., 2007. Treatment choices of hypertensive patients in Turkey. Behav. Med. 33, 5-10.
  • Uesawa, Y., Mohri, K., 2008. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm. Drug Dispos. 29,185-188.
  • Wilson, R.P., Freeman, A., Kazda, M.J., Andrews, T.C., Berry, L., Vaeth, P.A., Victor, R.G., 2002. Lay beliefs about high blood pressure in a low- to middle-income urban African-American community: an opportunity for improving hypertension control. Am. J. Med. 112, 26-30.
Year 2012, Volume: 29 Issue: 1, 38 - 41, 17.04.2012
https://doi.org/10.5835/jecm.omu.29.01.010

Abstract

References

  • Adibelli, Z., Dilek, M., Akpolat, T., 2009. Lemon juice as an alternative therapy in hypertension in Turkey. Int. J. Cardiol. 135, 58-59.
  • Altun, B., Arici, M., Nergizoğlu, G., Derici, U., Karatan, O., Turgan, C., Sindel, S., Erbay, B., Hasanoğlu, E., Cağlar, S., 2005. Prevalence, aware- ness, treatment and control of hypertension in Turkey (the PatenT study) in 2003. J. Hypertens. 23, 1817-1823.
  • Bailey, D.G., Dresser, G.K., Bend, J.R., 2003. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin. Pharmacol. Ther. 73, 529-537.
  • Bailey, D.G., Dresser, G.K., 2004. Interactions between grapefruit juice and cardiovascular drugs. Am. J. Cardiovasc. Drugs. 4, 281-297.
  • Betancourt, J.R., Carrillo, J.E., Gren, A.R., 1999. Hypertension in multicultural and minority populations: linking communication to compliance. Curr. Hypertens. Rep. 1, 482-488.
  • Capraz, M., Dilek, M., Akpolat, T., 2007. Garlic, hypertension and patient education. Int. J. Cardiol. 121, 130-131.
  • Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo, J.L. Jr., Jones, D.W., Materson, B.J., Oparil, S., Wright, J.T. Jr., Roccella, E.J.,2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 42, 1206-1252.
  • Díaz-Juárez, J.A., Tenorio-López, F.A., Zarco-Olvera, G., Valle-Mondragón, L.D., Torres-Narváez, J.C., Pastelín-Hernández, G., 2009. Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo. Phytother. Res. 23, 948-954.
  • Edwards, R.L., Lyon, T., Litwin, S.E., Rabovsky, A., Symons, J.D., Jalili, T., 2007. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 137, 2405-2411.
  • González-Molina, E., Domínguez-Perles, R., Moreno, D.A., García-Viguera, C., 2010. Natural bioactive compounds of Citrus limon for food and health. J. Pharm. Biomed. Anal. 51, 327-345.
  • Lilja, J.J., Raaska, K., Neuvonen P.J., 2005. Effects of orange juice on the pharmacokinetics of atenolol. Eur. J. Clin. Pharmacol. 61, 337-340.
  • Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A.M., Kjeldsen, S.E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynkiewicz, A., Schmieder, R.E., Boudier, H.A., Zanchetti, A., Vahanian, A., Camm, J., De Caterina, R., Dean,V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S.D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J.L., Erdine, S., Kiowski, W., Agabiti-Rosei, E., Ambrosioni, E., Lindholm, L.H., Viigimaa, M., Adamopoulos, S., Agabiti-Rosei, E., Ambrosioni, E., Bertomeu, V., Clement, D., Erdine, S., Farsang, C., Gaita, D., Lip, G., Mallion, J.M., Manolis, A.J., Nilsson, P.M., O'Brien, E., Ponikowski, P., Redon, J., Ruschitzka, F., Tamargo, J., van Zwieten, P., Waeber, B., Williams, B., 2007. Manage-ment of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 25, 1105-1187.
  • Perez-Vizcaino, F., Duarte, J., Jimenez, R., Santos-Buelga, C., Osuna, A., 2009. Antihypertensive effects of the flavonoid quercetin. Pharmacol. Rep. 61, 67-75.
  • Reshef, N., Hayari, Y., Goren, C., Boaz, M., Madar, Z., Knobler, H., 2005. Antihypertensive effect of sweetie fruit in patients with stage I hyper- tension. Am J. Hypertens. 18, 1360-1363.
  • Saito, M., Hirata-Koizumi, M., Matsumoto, M., Urano, T., Hasegawa, R., 2005. Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies. Drug Saf. 28, 677-694.
  • Toprak, D., Demir, S., 2007. Treatment choices of hypertensive patients in Turkey. Behav. Med. 33, 5-10.
  • Uesawa, Y., Mohri, K., 2008. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm. Drug Dispos. 29,185-188.
  • Wilson, R.P., Freeman, A., Kazda, M.J., Andrews, T.C., Berry, L., Vaeth, P.A., Victor, R.G., 2002. Lay beliefs about high blood pressure in a low- to middle-income urban African-American community: an opportunity for improving hypertension control. Am. J. Med. 112, 26-30.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Internal Medical Sciences
Authors

Aysel Sarı This is me

Nevzat Selim This is me

Melda Dilek This is me

Turkan Aydoğdu This is me

Zelal Adıbelli This is me

Piltan Büyükkaya This is me

Tekin Akpolat

Publication Date April 17, 2012
Submission Date February 10, 2012
Published in Issue Year 2012 Volume: 29 Issue: 1

Cite

APA Sarı, A., Selim, N., Dilek, M., Aydoğdu, T., et al. (2012). Effect of lemon juice on blood pressure. Journal of Experimental and Clinical Medicine, 29(1), 38-41. https://doi.org/10.5835/jecm.omu.29.01.010
AMA Sarı A, Selim N, Dilek M, Aydoğdu T, Adıbelli Z, Büyükkaya P, Akpolat T. Effect of lemon juice on blood pressure. J. Exp. Clin. Med. June 2012;29(1):38-41. doi:10.5835/jecm.omu.29.01.010
Chicago Sarı, Aysel, Nevzat Selim, Melda Dilek, Turkan Aydoğdu, Zelal Adıbelli, Piltan Büyükkaya, and Tekin Akpolat. “Effect of Lemon Juice on Blood Pressure”. Journal of Experimental and Clinical Medicine 29, no. 1 (June 2012): 38-41. https://doi.org/10.5835/jecm.omu.29.01.010.
EndNote Sarı A, Selim N, Dilek M, Aydoğdu T, Adıbelli Z, Büyükkaya P, Akpolat T (June 1, 2012) Effect of lemon juice on blood pressure. Journal of Experimental and Clinical Medicine 29 1 38–41.
IEEE A. Sarı, N. Selim, M. Dilek, T. Aydoğdu, Z. Adıbelli, P. Büyükkaya, and T. Akpolat, “Effect of lemon juice on blood pressure”, J. Exp. Clin. Med., vol. 29, no. 1, pp. 38–41, 2012, doi: 10.5835/jecm.omu.29.01.010.
ISNAD Sarı, Aysel et al. “Effect of Lemon Juice on Blood Pressure”. Journal of Experimental and Clinical Medicine 29/1 (June 2012), 38-41. https://doi.org/10.5835/jecm.omu.29.01.010.
JAMA Sarı A, Selim N, Dilek M, Aydoğdu T, Adıbelli Z, Büyükkaya P, Akpolat T. Effect of lemon juice on blood pressure. J. Exp. Clin. Med. 2012;29:38–41.
MLA Sarı, Aysel et al. “Effect of Lemon Juice on Blood Pressure”. Journal of Experimental and Clinical Medicine, vol. 29, no. 1, 2012, pp. 38-41, doi:10.5835/jecm.omu.29.01.010.
Vancouver Sarı A, Selim N, Dilek M, Aydoğdu T, Adıbelli Z, Büyükkaya P, Akpolat T. Effect of lemon juice on blood pressure. J. Exp. Clin. Med. 2012;29(1):38-41.