Mixed type Castleman’s disease with renal amyloidosis: Case report

Year 2013, Volume: 30 Issue: 1, 67 - 68, 26.03.2013

Emre Erdem , Dilek Erdem Nurol Arık , İdris Yücel

https://doi.org/10.5835/jecm.omu.30.01.015

Abstract

Castleman’s disease is a lymphoproliferative disorder and accompanying renal amyloidosis has been rarely described. We report a case of Castleman’s disease with nephrotic syndrome secondary to amyloidosis. A 28 year old woman who has been followed by our unit with two years of Castleman’s disease was referred to our clinic with newly diagnosed proteinuria and renal failure. Renal biopsy showed amyloid deposit and the patient was treated with colchicine. The patient did not respond to colchicine therapy and the renal failure rapidly progressed.

Keywords

Amyloidosis, Castleman’s disease, Colchicine, Proteinuria, Renal biopsy, Renal failure

References

• Androulaki, A., Giaslakiotis, K., Giakoumi, X., Aessopos, A., Lazaris, A.C., 2007. Localized Castleman’s disease associated with systemic AA amyloidosis. Regression of amyloid deposits after tumor removal. Ann. Hematol. 86, 55-57.
• Castleman, B., Iverson, L., Menendez, V.P., 1956. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer. 9, 822-830.
• Frizzera, G., Peterson, B.A., Bayrd, E.D., Goldman, A., 1985. A systemic lymphoproliferative disorder with morphologic features of Castle- man’s disaese: Clinical findings and clinicopathologic correlations in 15 patients. J. Clin. Oncol. 3, 1202-1216.
• Morita-Hoshi, Y., Tohda, S., Miura, O., Nara, N., 2008. An autopsy case of multisentric Castleman’s diasease associated with interstitial nephritis and secondary AA amyloidosis. Int. J. Hematol. 87, 69-74.
• Suneja, S., Chidambaram, M., Herzenberg, A.M., Bargman, J.M., 2009. Kidney involvement in multisentric castleman disease. Am. J. Kidney. Dis. 53, 550-554.
• Journal of Experimental and Clinical Medicine 30 (2013) 67-68