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The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration

Yıl 2013, Cilt 30, Sayı 1, 1 - 3, 26.03.2013
https://doi.org/10.5835/jecm.omu.30.01.001

Öz

In this study, we assessed the effect of at least three intraocular ranibizumab injections, which were performed for the treatment of subfoveal choroidal neovascularization (CNV) secondary to neovascular age related macular degeneration (AMD), on best corrected visual acuity (VA) and central macular thickness (CMT) in 89 patients who were classified by the component of lesion. Flouroscein angiography was performed and CNV have been classified in classic, occult or mixt (classic+occult) type. Best corrected VA was measured by Snellen card and was recorded in logMAR-logarithm of the minimum angle of resolution values. CMT was measured by optical coherence tomography. While CMT decreased significantly in patients with classic, mixt or occult type lesion (p=0.000; 0.011; 0.004, respectively), the increase in VA was detected only in patients with classic type lesion (p=0.001). A positive significant correlation between the decrease in CMT and the decrease in VA (logMAR) was reported only in the patients with occult type lesion (p=0.03). In conclusion, the anatomical improvement, that is seen as a result of the treatment of AMD with intravitreal ranibizumab injection, is not associated with the increase in visual acuity in all types of CNV. 

Kaynakça

  • Arias, L., Ruiz-Moreno, J., Gomez-Ulla, F., Fernandez, M., Montero J., 2009. 1-year retrospective review of ranibizumab for naive nonsubfoveal choroidal neovascularization secondary to age-related macular degeneration. Retina. 29, 1444-1449.
  • Bhatnagar, P., Spaide, R.F., Takahashı, B.S., Peragallo, J.H., Freund, K.B., Klancnik, Jr.J.M., Cooney, M.J., Slakter, J.S., Sorenson, J.A., Yan- nuzzi, L.A., 2007. Ranibizumab for treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina. 27, 846-850.
  • Bird, A.C., Bressler, N.M., Bressler, S.B., Chisholm, I.H., Coscas, G., Davis, M.D., de Jong, P.T., Klaver, C.C., Klein, B.E., Klein, R., 1995. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv. Ophthalmol. 39, 367-374.
  • Ferris, F.L., Fine, S.L., Hyman, L., 1984. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch. Ophthalmol- Chic. 102, 1640-1642.
  • Gardner, T.W., Antonetti, D.A., Barber, A.J., LaNoue, K.F., Levison, S.W., 2002. Diabetic retinopathy: More than meets the eye. Surv. Ophthal- mol. 47, 252-253.
  • Parravano, M., Francesco, O., Tedeschı, M., Chıaravallotı, A., Perıllo, L., Boccassını, B., Varano, M., 2010. Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration treated with ranibizumab. Retina. 30, 1017-1024.
  • Shin, H.J., Chung, H., Kım, H.C., 2011. Association between foveal microstructure and visual outcome in age-related macular degeneration. Retina. 31, 1627-1636.
  • Squirrell, D.M., Mawer, N.P., Mody, C.H., Brand, C.S., 2010. Visual outcome after intravitreal ranibizumab for wet age-related macular degen- eration. Retina. 30, 436-442.
  • Vujosevic, S., Midena, E., Pilotto, E., Radin, P.P., Chiesa, L., Cavar-zeran, F., 2006. Diabetic macular edema: Correlation between micro perim- etry and optical coherence tomography findings. Invest Ophth. Vis. Sci. 47, 3044-3051.

Yıl 2013, Cilt 30, Sayı 1, 1 - 3, 26.03.2013
https://doi.org/10.5835/jecm.omu.30.01.001

Öz

Kaynakça

  • Arias, L., Ruiz-Moreno, J., Gomez-Ulla, F., Fernandez, M., Montero J., 2009. 1-year retrospective review of ranibizumab for naive nonsubfoveal choroidal neovascularization secondary to age-related macular degeneration. Retina. 29, 1444-1449.
  • Bhatnagar, P., Spaide, R.F., Takahashı, B.S., Peragallo, J.H., Freund, K.B., Klancnik, Jr.J.M., Cooney, M.J., Slakter, J.S., Sorenson, J.A., Yan- nuzzi, L.A., 2007. Ranibizumab for treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina. 27, 846-850.
  • Bird, A.C., Bressler, N.M., Bressler, S.B., Chisholm, I.H., Coscas, G., Davis, M.D., de Jong, P.T., Klaver, C.C., Klein, B.E., Klein, R., 1995. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv. Ophthalmol. 39, 367-374.
  • Ferris, F.L., Fine, S.L., Hyman, L., 1984. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch. Ophthalmol- Chic. 102, 1640-1642.
  • Gardner, T.W., Antonetti, D.A., Barber, A.J., LaNoue, K.F., Levison, S.W., 2002. Diabetic retinopathy: More than meets the eye. Surv. Ophthal- mol. 47, 252-253.
  • Parravano, M., Francesco, O., Tedeschı, M., Chıaravallotı, A., Perıllo, L., Boccassını, B., Varano, M., 2010. Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration treated with ranibizumab. Retina. 30, 1017-1024.
  • Shin, H.J., Chung, H., Kım, H.C., 2011. Association between foveal microstructure and visual outcome in age-related macular degeneration. Retina. 31, 1627-1636.
  • Squirrell, D.M., Mawer, N.P., Mody, C.H., Brand, C.S., 2010. Visual outcome after intravitreal ranibizumab for wet age-related macular degen- eration. Retina. 30, 436-442.
  • Vujosevic, S., Midena, E., Pilotto, E., Radin, P.P., Chiesa, L., Cavar-zeran, F., 2006. Diabetic macular edema: Correlation between micro perim- etry and optical coherence tomography findings. Invest Ophth. Vis. Sci. 47, 3044-3051.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Surgery Medical Sciences
Yazarlar

Ebru CÖMERT>


Hakkı BİRİNCİ>


Yüksel SÜLLÜ>

Yayımlanma Tarihi 26 Mart 2013
Başvuru Tarihi 29 Ağustos 2012
Kabul Tarihi
Yayınlandığı Sayı Yıl 2013, Cilt 30, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { omujecm217267, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs Üniversitesi}, year = {2013}, volume = {30}, number = {1}, pages = {1 - 3}, doi = {10.5835/jecm.omu.30.01.001}, title = {The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration}, key = {cite}, author = {Cömert, Ebru and Birinci, Hakkı and Süllü, Yüksel} }
APA Cömert, E. , Birinci, H. & Süllü, Y. (2013). The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration . Journal of Experimental and Clinical Medicine , 30 (1) , 1-3 . DOI: 10.5835/jecm.omu.30.01.001
MLA Cömert, E. , Birinci, H. , Süllü, Y. "The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration" . Journal of Experimental and Clinical Medicine 30 (2013 ): 1-3 <https://dergipark.org.tr/tr/pub/omujecm/issue/20432/217267>
Chicago Cömert, E. , Birinci, H. , Süllü, Y. "The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration". Journal of Experimental and Clinical Medicine 30 (2013 ): 1-3
RIS TY - JOUR T1 - The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration AU - EbruCömert, HakkıBirinci, YükselSüllü Y1 - 2013 PY - 2013 N1 - doi: 10.5835/jecm.omu.30.01.001 DO - 10.5835/jecm.omu.30.01.001 T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 1 EP - 3 VL - 30 IS - 1 SN - 1309-4483-1309-5129 M3 - doi: 10.5835/jecm.omu.30.01.001 UR - https://doi.org/10.5835/jecm.omu.30.01.001 Y2 - 2022 ER -
EndNote %0 Journal of Experimental and Clinical Medicine The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration %A Ebru Cömert , Hakkı Birinci , Yüksel Süllü %T The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration %D 2013 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 30 %N 1 %R doi: 10.5835/jecm.omu.30.01.001 %U 10.5835/jecm.omu.30.01.001
ISNAD Cömert, Ebru , Birinci, Hakkı , Süllü, Yüksel . "The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration". Journal of Experimental and Clinical Medicine 30 / 1 (Mart 2013): 1-3 . https://doi.org/10.5835/jecm.omu.30.01.001
AMA Cömert E. , Birinci H. , Süllü Y. The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration. J. Exp. Clin. Med.. 2013; 30(1): 1-3.
Vancouver Cömert E. , Birinci H. , Süllü Y. The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration. Journal of Experimental and Clinical Medicine. 2013; 30(1): 1-3.
IEEE E. Cömert , H. Birinci ve Y. Süllü , "The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration", Journal of Experimental and Clinical Medicine, c. 30, sayı. 1, ss. 1-3, Mar. 2013, doi:10.5835/jecm.omu.30.01.001