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Assessment of ovarian tumor marker CA-125 during radiotherapy course

Yıl 2013, Cilt: 30 Sayı: 2, 137 - 139, 31.07.2013
https://doi.org/10.5835/jecm.omu.30.02.010

Öz

The antigen secretion by ovarian cancer (CA-125) has been assessed using Radio Immune Assay (RIA) technique among a hundred ovarian cancer patients who received radiotherapy course as radical treatment. The study revealed that, the ovarian cancer commonly associated with the age groups of 30-40 years old taking a percent of 68 relative to other age groups and the antigen CA-125 does not has relation with aging. While the radiotherapy shows it is efficiency in management of ovarian cancer by reducing the antigen CA-125 level from 134 ± 13.3 U/ml to 5.5 ± 2.1 U/ml relative to normal level of CA-125 (35 U/ml). Also there is significant relationship between the
cancer stage and the level of antigen CA-125 (R2=0.98).

Kaynakça

  • ACOG: American College of Obstetricians and Gynecologists, 2002. The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Obstet. Gynecol. 100, 1413-1416.
  • American Cancer Society. Cancer Facts and Figures. (2012). Atlanta, GA.
  • Bast, R.C. Jr., Feeney, M., Lazarus, M., Nadler, L.M., Colvin, R.B., Knapp, R.C., 1981. Reactivity of a monoclonal antibody with human ovarian carcinoma. J. Clin. Invest. 68, 1331-1337.
  • Bast, R.C. Jr., Klug, T.L., ST. John, E., 1983. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 308, 883-887.
  • Bhattacharya, M., Chatterjee, S.K., Barlow, J.J., Fuji, H. 1982. Monoclonal antibodies recognizing Tumour-associated antigens of human ovar- ian mucinous cystadenocarcinomas. Cancer Res. 42, 1650-1654.
  • Canney, P.A., Moore M., Wilkinson, P.M., James, R.D., 1984. Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumor marker. Brth. J. Cancer. 50, 765-769.
  • Coussy, F., Chéreau, E., Daraï, E., Dhombres, F., Lotz, J.P., Rouzier, R., Selle, F., 2011. Interest of CA 125 level in management of ovarian can- cer. Gynecol. Obstet. Fertil. 39, 296-301.
  • Donaldson, E.S., Van Nagell, J.R., Pursell, S., 1980. Multiple biochemical markers on patients with gynaecologic malignancies. Cancer. 45, 948-953.
  • Goone Wardene, T.I., 2007. Management of asymptomatic patients on follow-up for ovarian cancer with rising CA-125 concentrations. Lancet Oncol. 8, 813-821.
  • Gregory, P. Beehler., Manveen S., Julie, A. B., Barbara E. T., Susan, E. M., Kerry J. R., and Kirsten B. M., 2006. Risk of ovarian cancer associ- ated with BMI varies by menopausal status.J. Nutr. 136, 2881–2886.
  • Hogdall, E., 2008. Cancer antigen CA-125 and prognosis. Curr. Opin. Obstet. Gynecol. 20, 4-8.
  • Keys, A., Fidanza, F., Karvonen, M.J., Kimura, N., Taylor, H.L., 1972. Indices of relative weight and adiposity. J. Chronic. Dis. 25, 329-343.
  • Kramer, J.L., Greene, M.H., 2004. Epidemiology of Ovarian, Fallopian Tube, and Primary Peritoneal Cancers. in: Gynecologic Cancer: Contro- versies in Management. Gershenson, D., Gore, M., McGuire, W., Quinn, M., Thomas, G., editors. Elsevier Science. pp. 327-340.
  • Manolov, V., Marinov, B., Vasilev, V., 2012. HE4 and CA125 in ovarian cancer. Akush. Ginekol. 51, 21-28.
  • NCCN: National Comprehensive Cancer Network, 2009. NCCN Practice Guidelines in Oncology: Ovarian cancer, Vol. 2.
  • Rustin, G.J.S., Nelstrop, A.E., Bentzen, S.M., Piccart, M.J., Bertelsen, K., 1999. Use of tumour markers in monitoring the course of ovarian cancer. Ann. Oncology. 10, 21-27.
  • Rustin, G.J.S., Nelstrop, A.E., Tuxen, M.K, Lambert, H.E., 1996. Defining progression of ovarian carcinoma during follow-up according to CA-125: A North Thames Ovary Group Study. Ann. Oncology. 7, 361-364.
  • Sproston, A.R.M., Roberts, S.A., Davidson, S.E., Hunter, R.D. , West, C.M.L., 1995. Serum tumor markers in carcinoma of the uterine cervix and outcome following radiotherapy. Brith. J. Cancer. 72,1536-1540.
  • Tietz, N.W. (Ed)., 1995. Clinical guide to laboratory tests, 3rd. ed. W. B. Saunders, Philadelphia, PA .pp.
  • Yin, B.W., Lloyd, K.O., 2001. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J. Biol. Chem. 276, 27371-27375. Ali Omer et al.
Yıl 2013, Cilt: 30 Sayı: 2, 137 - 139, 31.07.2013
https://doi.org/10.5835/jecm.omu.30.02.010

Öz

Kaynakça

  • ACOG: American College of Obstetricians and Gynecologists, 2002. The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Obstet. Gynecol. 100, 1413-1416.
  • American Cancer Society. Cancer Facts and Figures. (2012). Atlanta, GA.
  • Bast, R.C. Jr., Feeney, M., Lazarus, M., Nadler, L.M., Colvin, R.B., Knapp, R.C., 1981. Reactivity of a monoclonal antibody with human ovarian carcinoma. J. Clin. Invest. 68, 1331-1337.
  • Bast, R.C. Jr., Klug, T.L., ST. John, E., 1983. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 308, 883-887.
  • Bhattacharya, M., Chatterjee, S.K., Barlow, J.J., Fuji, H. 1982. Monoclonal antibodies recognizing Tumour-associated antigens of human ovar- ian mucinous cystadenocarcinomas. Cancer Res. 42, 1650-1654.
  • Canney, P.A., Moore M., Wilkinson, P.M., James, R.D., 1984. Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumor marker. Brth. J. Cancer. 50, 765-769.
  • Coussy, F., Chéreau, E., Daraï, E., Dhombres, F., Lotz, J.P., Rouzier, R., Selle, F., 2011. Interest of CA 125 level in management of ovarian can- cer. Gynecol. Obstet. Fertil. 39, 296-301.
  • Donaldson, E.S., Van Nagell, J.R., Pursell, S., 1980. Multiple biochemical markers on patients with gynaecologic malignancies. Cancer. 45, 948-953.
  • Goone Wardene, T.I., 2007. Management of asymptomatic patients on follow-up for ovarian cancer with rising CA-125 concentrations. Lancet Oncol. 8, 813-821.
  • Gregory, P. Beehler., Manveen S., Julie, A. B., Barbara E. T., Susan, E. M., Kerry J. R., and Kirsten B. M., 2006. Risk of ovarian cancer associ- ated with BMI varies by menopausal status.J. Nutr. 136, 2881–2886.
  • Hogdall, E., 2008. Cancer antigen CA-125 and prognosis. Curr. Opin. Obstet. Gynecol. 20, 4-8.
  • Keys, A., Fidanza, F., Karvonen, M.J., Kimura, N., Taylor, H.L., 1972. Indices of relative weight and adiposity. J. Chronic. Dis. 25, 329-343.
  • Kramer, J.L., Greene, M.H., 2004. Epidemiology of Ovarian, Fallopian Tube, and Primary Peritoneal Cancers. in: Gynecologic Cancer: Contro- versies in Management. Gershenson, D., Gore, M., McGuire, W., Quinn, M., Thomas, G., editors. Elsevier Science. pp. 327-340.
  • Manolov, V., Marinov, B., Vasilev, V., 2012. HE4 and CA125 in ovarian cancer. Akush. Ginekol. 51, 21-28.
  • NCCN: National Comprehensive Cancer Network, 2009. NCCN Practice Guidelines in Oncology: Ovarian cancer, Vol. 2.
  • Rustin, G.J.S., Nelstrop, A.E., Bentzen, S.M., Piccart, M.J., Bertelsen, K., 1999. Use of tumour markers in monitoring the course of ovarian cancer. Ann. Oncology. 10, 21-27.
  • Rustin, G.J.S., Nelstrop, A.E., Tuxen, M.K, Lambert, H.E., 1996. Defining progression of ovarian carcinoma during follow-up according to CA-125: A North Thames Ovary Group Study. Ann. Oncology. 7, 361-364.
  • Sproston, A.R.M., Roberts, S.A., Davidson, S.E., Hunter, R.D. , West, C.M.L., 1995. Serum tumor markers in carcinoma of the uterine cervix and outcome following radiotherapy. Brith. J. Cancer. 72,1536-1540.
  • Tietz, N.W. (Ed)., 1995. Clinical guide to laboratory tests, 3rd. ed. W. B. Saunders, Philadelphia, PA .pp.
  • Yin, B.W., Lloyd, K.O., 2001. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J. Biol. Chem. 276, 27371-27375. Ali Omer et al.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Basic Medical Sciences
Yazarlar

Mohammed Alıomer

Mohamed Mohamed Bu kişi benim

Mohamed Yousef

Mohammed Farahna Bu kişi benim

Adel Alghanım Bu kişi benim

Yayımlanma Tarihi 31 Temmuz 2013
Gönderilme Tarihi 12 Mayıs 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 30 Sayı: 2

Kaynak Göster

APA Alıomer, M., Mohamed, M., Yousef, M., Farahna, M., vd. (2013). Assessment of ovarian tumor marker CA-125 during radiotherapy course. Journal of Experimental and Clinical Medicine, 30(2), 137-139. https://doi.org/10.5835/jecm.omu.30.02.010
AMA Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. Temmuz 2013;30(2):137-139. doi:10.5835/jecm.omu.30.02.010
Chicago Alıomer, Mohammed, Mohamed Mohamed, Mohamed Yousef, Mohammed Farahna, ve Adel Alghanım. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine 30, sy. 2 (Temmuz 2013): 137-39. https://doi.org/10.5835/jecm.omu.30.02.010.
EndNote Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A (01 Temmuz 2013) Assessment of ovarian tumor marker CA-125 during radiotherapy course. Journal of Experimental and Clinical Medicine 30 2 137–139.
IEEE M. Alıomer, M. Mohamed, M. Yousef, M. Farahna, ve A. Alghanım, “Assessment of ovarian tumor marker CA-125 during radiotherapy course”, J. Exp. Clin. Med., c. 30, sy. 2, ss. 137–139, 2013, doi: 10.5835/jecm.omu.30.02.010.
ISNAD Alıomer, Mohammed vd. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine 30/2 (Temmuz 2013), 137-139. https://doi.org/10.5835/jecm.omu.30.02.010.
JAMA Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. 2013;30:137–139.
MLA Alıomer, Mohammed vd. “Assessment of Ovarian Tumor Marker CA-125 During Radiotherapy Course”. Journal of Experimental and Clinical Medicine, c. 30, sy. 2, 2013, ss. 137-9, doi:10.5835/jecm.omu.30.02.010.
Vancouver Alıomer M, Mohamed M, Yousef M, Farahna M, Alghanım A. Assessment of ovarian tumor marker CA-125 during radiotherapy course. J. Exp. Clin. Med. 2013;30(2):137-9.