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Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields

Yıl 2014, Cilt: 31 Sayı: 2, 0 - , 10.09.2014

Öz

 In the present study it was aimed to analyse the effect of prenatal exposure to 900 MHz electromagnetic fields (EMF) on the number of pyramidal cells in the cornu ammonis (CA) of hippocampus of the 4-weeks old male rats by using the optical fractionator stereological technique. We used melatonin (N-aceyl-5-methoxytryptamine) and omega-3 (w3) for searching the neuroprotective effects against EMF exposure. Pregnant rats were randomly divided into seven groups (three pregnant rats for each group).These are EMF group, EMF+melatonin group (EMF+Mel), EMF+omega-3 group (EMF+w3), melatonin group (MEL), omega group (w3), sham group, and control group (Cont). Three of these groups that EMF, EMF+MEL, EMF+w3, were exposed to 900 MHz EMF for 60 min/day from the first to the last day of the gestation period in an exposure tube. The Cont, MEL and w3 groups were not placed into the tube nor were they exposed to EMF. The rats of Sham group were placed into the tube without exposure of EMF. At the end of 4 weeks, offspring were anesthetized then perfused with neutral formalin intracardially and brains were removed and histologically processed. Paraffin sections of the hippocampus were used for analysis. It was found that exposure of 900 MHz EMF significantly reduced the total pyramidal cell number in the CA of the EMF group as compared to others expect w3 group. In w3 group there was significant decrease in number of pyramidal cells according to our study results. It was observed that w3, without EMF exposure, shown toxic effects on pyramidal cell but there was opposite evidence suggesting that w3 has a protective role against EMF exposure in EMF+w3 group. Melatonin increased the pyramidal cell number in groups of MEL and EMF+MEL. This study shows some evidences for neuroprotective effects of melatonin on pyramidal cells. Finally in sham-exposed group, stress caused to increase in the number of pyramidal cells by induction of neurogenesis.

Yıl 2014, Cilt: 31 Sayı: 2, 0 - , 10.09.2014

Öz

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Ayrıntılar

Birincil Dil İngilizce
Bölüm Basic Medical Sciences
Yazarlar

Gülüna Erdem Koç

Süleyman Kaplan Bu kişi benim

Gamze Altun Bu kişi benim

Hasan Gümüş Bu kişi benim

Ömür Gülsüm Deniz Bu kişi benim

İşınsu Aydın Bu kişi benim

Mehmet Emin Önger Bu kişi benim

Berrin Zühal Altunkaynak Bu kişi benim

Yayımlanma Tarihi 10 Eylül 2014
Gönderilme Tarihi 10 Eylül 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 31 Sayı: 2

Kaynak Göster

APA Erdem Koç, G., Kaplan, S., Altun, G., Gümüş, H., vd. (2014). Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields. Journal of Experimental and Clinical Medicine, 31(2). https://doi.org/10.5835/jecm.v2i31.5000068741
AMA Erdem Koç G, Kaplan S, Altun G, Gümüş H, Deniz ÖG, Aydın İ, Önger ME, Altunkaynak BZ. Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields. J. Exp. Clin. Med. Eylül 2014;31(2). doi:10.5835/jecm.v2i31.5000068741
Chicago Erdem Koç, Gülüna, Süleyman Kaplan, Gamze Altun, Hasan Gümüş, Ömür Gülsüm Deniz, İşınsu Aydın, Mehmet Emin Önger, ve Berrin Zühal Altunkaynak. “Neuroprotective Effect of Melatonin and Omega-3 on the Hippocampus of Rat That Prenatally Exposed to 900 Mhz Electromagnetic Fields”. Journal of Experimental and Clinical Medicine 31, sy. 2 (Eylül 2014). https://doi.org/10.5835/jecm.v2i31.5000068741.
EndNote Erdem Koç G, Kaplan S, Altun G, Gümüş H, Deniz ÖG, Aydın İ, Önger ME, Altunkaynak BZ (01 Eylül 2014) Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields. Journal of Experimental and Clinical Medicine 31 2
IEEE G. Erdem Koç, “Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields”, J. Exp. Clin. Med., c. 31, sy. 2, 2014, doi: 10.5835/jecm.v2i31.5000068741.
ISNAD Erdem Koç, Gülüna vd. “Neuroprotective Effect of Melatonin and Omega-3 on the Hippocampus of Rat That Prenatally Exposed to 900 Mhz Electromagnetic Fields”. Journal of Experimental and Clinical Medicine 31/2 (Eylül 2014). https://doi.org/10.5835/jecm.v2i31.5000068741.
JAMA Erdem Koç G, Kaplan S, Altun G, Gümüş H, Deniz ÖG, Aydın İ, Önger ME, Altunkaynak BZ. Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields. J. Exp. Clin. Med. 2014;31. doi:10.5835/jecm.v2i31.5000068741.
MLA Erdem Koç, Gülüna vd. “Neuroprotective Effect of Melatonin and Omega-3 on the Hippocampus of Rat That Prenatally Exposed to 900 Mhz Electromagnetic Fields”. Journal of Experimental and Clinical Medicine, c. 31, sy. 2, 2014, doi:10.5835/jecm.v2i31.5000068741.
Vancouver Erdem Koç G, Kaplan S, Altun G, Gümüş H, Deniz ÖG, Aydın İ, Önger ME, Altunkaynak BZ. Neuroprotective effect of melatonin and omega-3 on the hippocampus of rat that prenatally exposed to 900 mhz electromagnetic fields. J. Exp. Clin. Med. 2014;31(2).