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Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis

Year 2016, Volume: 33 Issue: 3, 183 - 186, 06.01.2017

Abstract


















Respiratory Epithelial Adenomatoid Hamartoma (REAH) is a type of hamartoma characterized by prominent glandular proliferations lined with ciliated respiratory epithelium originating from the surface epithelium. REAH should be differentiated from inflammatory nasal polyp, inverted papilloma and adenocarcinoma to avoid from more aggressive surgery then is needed for the REAH and to avoid from unnecessary long-term follow-up with medical treatments. In this report, we present a case of REAH who was followed up with topical and systemic steroids for years with the misdiagnosis of inflamatory nasal polyposis and discuss the clinical, radiological and histopathological features of the disease at increasing importance in recent years. 


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References

  • Braun, J.J., Riehm, S., Averous, G., Billing, A., Veillon, F., 2013. MRI in respiratory epithelial adenomatoid hamartoma of nasal cavities. J. Neuroradiol. 40, 216-219. doi: 10.1016/j.neurad.2012.04.002.
  • Cao, Z., Gu, Z., Yang, J., Jin, M., 2010. Respiratory epithelial adenomatoid hamartoma of bilateral olfactory clefts associated with nasal polyposis: Three cases report and literature review. Auris Nasus Larynx. 37, 352-356. doi: 10.1016/j.anl.2009.10.003.
  • Fitzhugh, V.A., Mirani, N., 2008. Respiratory epithelial adenomatoid hamartoma: A review. Head Neck Pathol. 2, 203-220. doi: 10.1007/s12105-008-0064-3.
  • Gauchotte, G., Marie, B., Gallet, P., Nguyen, D.T., Grandhaye, M., Jankowski, R., Vignaud, J.M., 2013. Respiratory epithelial adenomatoid hamartoma: A poorly recognized entity with mast cell recruitment and frequently associated with nasal polyposis. Am. J. Surg. Pathol. 37, 1678-1685. doi: 10.1097/PAS.0000000000000092.
  • Hawley, K.A., Ahmed, M., Sindwani, R., 2013. CT findings of sinonasal respiratory epithelial adenomatoid hamartoma: A closer look at the olfactory clefts. Am. J. Neuroradiol. 34, 1086-1090.
  • Himi, Y., Yoshizaki, T., Sato, K., Furukawa, M., 2002. Respiratory epithelial adenomatoid hamartoma of the maxillary sinus. J. Laryngol. Otol. 116, 317-318.
  • Hua, X., Huang, X., Liao, Z., Xian, Q., Yu, L., 2014. Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma. Diagn. Pathol. 25, 9:70. doi: 10.1186/1746-1596-9-70.
  • Ingram, W.F., Noone, M.C., Gillespie, M.B., 2006. Respiratory epithelial adenomatoid hamartoma: A case report. Ear Nose Throat. J. 85, 190-192.
  • Lee, J.T., Garg, R, Brunworth, J., Keschner, D.B., Thompson, L.D., 2013. Sinonasal respiratory epithelial adenomatoid hamartomas: Series of 51 cases and literature review. Am. J. Rhinol. Allergy. 27, 322-328. doi: 10.2500/ajra.2013.27.3905.
  • Liang, J., O’Malley, B.W.Jr., Feldman, M., Newman, J.G., 2007. A case of respiratory epithelial adenomatoid hamartoma. Am. J. Otolaryngol. 28, 277-279.
  • Lorentz, C., Marie, B., Vignaud, J.M., Jankowski, R., 2012. Respiratory epithelial adenomatoid hamartomas of the olfactory clefts Eur. Arch. Otorhinolaryngol. 269, 847-852. doi: 10.1007/s00405-011-1713-9.
  • Metselaar, R.M., Stel, H.V., van der Baan, S., 2005. Respiratory epithelial adenomatoid in the nasopharynx. J. Laryngol. Otol. 119, 476-478.
  • Mühlmeier, G., Hausch, R., Arndt, A., Kraft, K., Danz, B., Maier, H., 2014. Respiratory epithelial adenomatoid hamartoma of the nose and nasal sinuses: A rare differential diagnosis of nasal polyposis. HNO. 62, 813-817. doi: 10.1007/s00106-014-2914-5.
  • Nguyen, D.T., Nguyen-Thi, P.L., Gauchotte, G., Arous, F., Vignaud, J.M., Jankowski, R., 2014. Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis. Laryngoscope. 124, 2461-2465. doi: 10.1002/ lary.24778.
  • Ozolek, J.A., Barnes, E.L., Hunt, J.L., 2007. Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: An immunohistochemical study. Arch. Pathol. Lab. Med. 131, 530-537.
  • Roffman, E., Baredes, S., Mirani, N., 2006. Respiratory epithelial adenomatoid hamartomas and chondroosseous respiratory epithelial hamartomas of the sinonasal tract: A case series and literature review. Am. J. Rhinol. 20, 586-590.
  • Vira, D., Bhuta, S., Wang, M.B., 2011. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 121, 2706-2709.
  • Wenig, B.M., Heffner, D.K., 1995. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: A clinicopathologic study of 31 cases. Ann. Otol. Rhinol. Laryngol. 104, 639-645.
Year 2016, Volume: 33 Issue: 3, 183 - 186, 06.01.2017

Abstract

References

  • Braun, J.J., Riehm, S., Averous, G., Billing, A., Veillon, F., 2013. MRI in respiratory epithelial adenomatoid hamartoma of nasal cavities. J. Neuroradiol. 40, 216-219. doi: 10.1016/j.neurad.2012.04.002.
  • Cao, Z., Gu, Z., Yang, J., Jin, M., 2010. Respiratory epithelial adenomatoid hamartoma of bilateral olfactory clefts associated with nasal polyposis: Three cases report and literature review. Auris Nasus Larynx. 37, 352-356. doi: 10.1016/j.anl.2009.10.003.
  • Fitzhugh, V.A., Mirani, N., 2008. Respiratory epithelial adenomatoid hamartoma: A review. Head Neck Pathol. 2, 203-220. doi: 10.1007/s12105-008-0064-3.
  • Gauchotte, G., Marie, B., Gallet, P., Nguyen, D.T., Grandhaye, M., Jankowski, R., Vignaud, J.M., 2013. Respiratory epithelial adenomatoid hamartoma: A poorly recognized entity with mast cell recruitment and frequently associated with nasal polyposis. Am. J. Surg. Pathol. 37, 1678-1685. doi: 10.1097/PAS.0000000000000092.
  • Hawley, K.A., Ahmed, M., Sindwani, R., 2013. CT findings of sinonasal respiratory epithelial adenomatoid hamartoma: A closer look at the olfactory clefts. Am. J. Neuroradiol. 34, 1086-1090.
  • Himi, Y., Yoshizaki, T., Sato, K., Furukawa, M., 2002. Respiratory epithelial adenomatoid hamartoma of the maxillary sinus. J. Laryngol. Otol. 116, 317-318.
  • Hua, X., Huang, X., Liao, Z., Xian, Q., Yu, L., 2014. Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma. Diagn. Pathol. 25, 9:70. doi: 10.1186/1746-1596-9-70.
  • Ingram, W.F., Noone, M.C., Gillespie, M.B., 2006. Respiratory epithelial adenomatoid hamartoma: A case report. Ear Nose Throat. J. 85, 190-192.
  • Lee, J.T., Garg, R, Brunworth, J., Keschner, D.B., Thompson, L.D., 2013. Sinonasal respiratory epithelial adenomatoid hamartomas: Series of 51 cases and literature review. Am. J. Rhinol. Allergy. 27, 322-328. doi: 10.2500/ajra.2013.27.3905.
  • Liang, J., O’Malley, B.W.Jr., Feldman, M., Newman, J.G., 2007. A case of respiratory epithelial adenomatoid hamartoma. Am. J. Otolaryngol. 28, 277-279.
  • Lorentz, C., Marie, B., Vignaud, J.M., Jankowski, R., 2012. Respiratory epithelial adenomatoid hamartomas of the olfactory clefts Eur. Arch. Otorhinolaryngol. 269, 847-852. doi: 10.1007/s00405-011-1713-9.
  • Metselaar, R.M., Stel, H.V., van der Baan, S., 2005. Respiratory epithelial adenomatoid in the nasopharynx. J. Laryngol. Otol. 119, 476-478.
  • Mühlmeier, G., Hausch, R., Arndt, A., Kraft, K., Danz, B., Maier, H., 2014. Respiratory epithelial adenomatoid hamartoma of the nose and nasal sinuses: A rare differential diagnosis of nasal polyposis. HNO. 62, 813-817. doi: 10.1007/s00106-014-2914-5.
  • Nguyen, D.T., Nguyen-Thi, P.L., Gauchotte, G., Arous, F., Vignaud, J.M., Jankowski, R., 2014. Predictors of respiratory epithelial adenomatoid hamartomas of the olfactory clefts in patients with nasal polyposis. Laryngoscope. 124, 2461-2465. doi: 10.1002/ lary.24778.
  • Ozolek, J.A., Barnes, E.L., Hunt, J.L., 2007. Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: An immunohistochemical study. Arch. Pathol. Lab. Med. 131, 530-537.
  • Roffman, E., Baredes, S., Mirani, N., 2006. Respiratory epithelial adenomatoid hamartomas and chondroosseous respiratory epithelial hamartomas of the sinonasal tract: A case series and literature review. Am. J. Rhinol. 20, 586-590.
  • Vira, D., Bhuta, S., Wang, M.B., 2011. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 121, 2706-2709.
  • Wenig, B.M., Heffner, D.K., 1995. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: A clinicopathologic study of 31 cases. Ann. Otol. Rhinol. Laryngol. 104, 639-645.
There are 18 citations in total.

Details

Journal Section Basic Medical Sciences
Authors

Emre Gunbey

Esra Kavaz This is me

Bilge Can Meydan This is me

Hediye Pinar Gunbey This is me

Hulya Savas Mutlu This is me

Recep Unal This is me

Publication Date January 6, 2017
Submission Date January 4, 2017
Acceptance Date May 10, 2016
Published in Issue Year 2016 Volume: 33 Issue: 3

Cite

APA Gunbey, E., Kavaz, E., Can Meydan, B., Pinar Gunbey, H., et al. (2017). Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis. Journal of Experimental and Clinical Medicine, 33(3), 183-186.
AMA Gunbey E, Kavaz E, Can Meydan B, Pinar Gunbey H, Savas Mutlu H, Unal R. Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis. J. Exp. Clin. Med. January 2017;33(3):183-186.
Chicago Gunbey, Emre, Esra Kavaz, Bilge Can Meydan, Hediye Pinar Gunbey, Hulya Savas Mutlu, and Recep Unal. “Respiratory Epithelial Adenomatoid Hamartoma With Inflammatory Nasal Polyposis”. Journal of Experimental and Clinical Medicine 33, no. 3 (January 2017): 183-86.
EndNote Gunbey E, Kavaz E, Can Meydan B, Pinar Gunbey H, Savas Mutlu H, Unal R (January 1, 2017) Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis. Journal of Experimental and Clinical Medicine 33 3 183–186.
IEEE E. Gunbey, E. Kavaz, B. Can Meydan, H. Pinar Gunbey, H. Savas Mutlu, and R. Unal, “Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis”, J. Exp. Clin. Med., vol. 33, no. 3, pp. 183–186, 2017.
ISNAD Gunbey, Emre et al. “Respiratory Epithelial Adenomatoid Hamartoma With Inflammatory Nasal Polyposis”. Journal of Experimental and Clinical Medicine 33/3 (January 2017), 183-186.
JAMA Gunbey E, Kavaz E, Can Meydan B, Pinar Gunbey H, Savas Mutlu H, Unal R. Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis. J. Exp. Clin. Med. 2017;33:183–186.
MLA Gunbey, Emre et al. “Respiratory Epithelial Adenomatoid Hamartoma With Inflammatory Nasal Polyposis”. Journal of Experimental and Clinical Medicine, vol. 33, no. 3, 2017, pp. 183-6.
Vancouver Gunbey E, Kavaz E, Can Meydan B, Pinar Gunbey H, Savas Mutlu H, Unal R. Respiratory epithelial adenomatoid hamartoma with inflammatory nasal polyposis. J. Exp. Clin. Med. 2017;33(3):183-6.