Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

Year 2017, Volume: 34 Issue: 2, 83 - 87, 08.09.2017

Sibel Dogan , Basak Yalcin Nilgun Atakan Ahu Yorulmaz Ferda Artuz

Abstract

Behçet’s disease (BD) is a severe in ammatory vasculitis which is very
common among Turkish population. Recently, IRGM1 (rs13361189), PTGER4
(rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be
associated with several in ammatory diseases. In this study, we investigated
the association of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8
(rs2043211) polymorphisms with BD and their probable implications on
clinical manifestations of BD in a Turkish patient cohort. 116 patients and
150 healthy controls genomic DNA were studied. Allele-speci c primers were
used for genotyping. No signi cant difference was found between patient and
controls according to genotypic distribution and allelic frequencies of IRGM1
(rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) (p>0.05). No
statistically signi cant difference was found in genotypic or allellic distribution of
the same polymorphisms according to gender or clinical characteristics between
patients and controls (p>0.05). Our study is to our knowledge the rst report
from Turkey regarding BD and IRGM1 (rs13361189), PTGER4 (rs1373692)
and CARD8 (rs2043211) polymorphisms. IRGM gene polymorphisms seems
to cause predilection for autoimmunity in certain ethnic groups but not in
Turkish BD patients. CARD8 gene polymorphisms and other in ammasome
related genes may play a role in immune pathomechanisms in BD and separate
studies including BD patients with similar clinical characteristics are required
for investigating different SNPs as a probable disease susceptibility factor. 

Keywords

Behçet’s disease, CARD8, IRGM1, PTGER4, SNP

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