Analysis of Orosomucoid and C-Reactive Protein Levels in Gingival Tissue And Serum of Rats with Experimental Periodontitis: Comparison at different time points in disease progression

Year 2017, Volume: 34 Issue: 4, 269 - 274, 10.10.2019

Figen Öngöz Dede , Umut Ballı , Mustafa Cenk Durmuşlar , Şeyma Bozkurt Doğan Bahattin Avcı , Bülent Ayas , Özgür Korhan Tunçel

Abstract

Objectives: Acute-phase proteins are thought to trigger
periodontal tissue destruction. The core purpose of this study is to analyze
the levels of Orosomucoid1 (ORM1) and C-reactive protein (CRP) in gingival
tissue and serum of rats with experimental periodontitis.

Material and Methods: Thirty rats were divided randomly and Group 1 was
specified as control group, while the remaining groups were classified as ligature-induced
experimental periodontitis groups. Each group was constituted 10 rats and Group
2 was evaluated the impact of ligature for the term of 7 days. Group 3 was
classified on the basis of 14 days ligature. With the help of ELISA, gingival
tissue and serum samples was utilized for measuring CRP and ORM1 levels.

Results: Alveolar bone and attachment loss was statistically
higher in all experimental periodontitis groups than those in control group (P<0.001). The levels of CRP and ORM1
in gingival tissue were significantly higher in Group 2 than in Groups 1 and 3 (P<0.05). Also, a statistically
significant positive correlation was found between CRP and ORM1 levels in the
gingival tissue (P<0.001).

Conclusions: The present results reveal that tissue destruction at
earlier periods of inflammatory periodontal disease may be associated with ORM. 

Keywords

Orosomucoid; periodontitis; gingiva

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