Yıl 2017, Cilt 34 , Sayı 4, Sayfalar 275 - 278 2019-10-10

Neuroendocrine carcinoma of the rectum

Alparslan Serarslan [1] , Nilgun Ozbek Okumus [2] , Filiz Karagoz [3] , Mehmet Selim Nural [4] , Bilge Gürsel [5] , Deniz Meydan [6]


Neuroendocrine carcinoma (NEC) of the rectum is rare. Most patients have metastatic disease at the time of diagnosis. These malignancies have a worse prognosis compared with conventional adenocarcinoma, and there is no stan- dard treatment protocol. We report herein a case of NEC of the rectum with a short survival. A 60-year-old female was admitted to the emergency service with jaundice, abdominal pain, back pain and confusion, without a history of rectal bleeding. The imaging studies showed a rectal tumor, abdominal lymph- adenopathies, and multiple liver and vertebral metastases. Rectal biopsy was performed. The histopathologic findings were consistent with those of NEC. Palliative radiotherapy was planned for the spinal metastases, but the patient died before completing radiotherapy, within 1 month from diagnosis. In con- clusion, these neoplasms show a dramatic course, particularly in metastatic pa- tients, and there is a clear need for studies involving larger numbers of colon and rectum NEC patients. 

Carcinoma, Case management, Neuroendocrine, Rare diseases, Rectum
  • Aytac, E., Ozdemir, Y., Ozuner, G., 2014. Long term outcomes of neuroendocrine carcinomas (high-grade neuroendocrine tumors) of the colon, rectum, and anal canal. J. Visc. Surg. 151, 3-7.
  • Errasti, A.J., Espín, B.E., Reina, D.A., 2014. Rare tumors of the rectum. Narrative review. Cir. Esp. 92, 579-588.
  • Gould, V.E., Chejfec, G., 1978. Neuroendocrine carcinomas of the colon. Ultrastructural and biochemical evidence of their secretory function. Am. J. Surg. Pathol. 2, 31-38.
  • Kang, H., O’Connell, J.B., Leonardi, M.J., Maggard, M.A., McGory, M.L., Ko, C.Y., 2007. Rare tumors of the colon and rectum: a national review. Int. J. Colorectal. Dis. 22, 183-189.
  • Minocha, V., Shuja, S., Ali, R., Eid, E., 2014. Large cell neuroendocrine carcinoma of the rectum presenting with extensive metastatic disease. Case. Rep. Oncol. Med. 2014, 386379.
  • Miyamoto, H., Kurita, N., Nishioka, M., Ando, T., Tashiro, T., Hirokawa, M., Shimada, M., 2006. Poorly differentiated neuroendocrine cell carcinoma of the rectum: report of a case and literal review. J. Med. Invest. 53, 317-320.
  • Nojima, H., Seike, K., Kosugi, C., Shida, T., Koda, K., Oda, K., Kamata, S., Ishikura, H., Miyazaki, M., 2010. Advanced moderately differentiated neuroendocrine carcinoma of the rectum with favorable prognosis by postoperative chemoradiation. World. J. Surg. Oncol. 8, 29.
  • Okuyama, T., Korenaga, D., Tamura, S., Yao, T., Maekawa, S., Watanabe, A., Ikeda, T., Sugimachi, K., 1999. The effectiveness of chemotherapy with cisplatin and 5-fluorouracil for recurrent small cell neuroendocrine carcinoma of the rectum: report of a case. Surg. Today. 29, 165-169.
  • Öberg, K., Knigge, U., Kwekkeboom, D., Perren, A., ESMO Guidelines Working Group, 2012. Neuroendocrine gastro-entero- pancreatic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 23, 124-130.
  • Shafqat, H., Ali, S., Salhab, M., Olszewski, A.J., 2015. Survival of patients with neuroendocrine carcinoma of the colon and rectum: a population-based analysis. Dis. Colon. Rectum. 58, 294-303.
  • Smith, J.D., Reidy, D.L., Goodman, K.A., Shia, J., Nash, G.M., 2014. A retrospective review of 126 high-grade neuroendocrine carcinomas of the colon and rectum. Ann. Surg. Oncol. 21, 2956-2962.
  • Sorbye, H., Welin, S., Langer, S.W., Vestermark, L.W., Holt, N., Osterlund, P., Dueland, S., Hofsli, E., Guren, M.G., Ohrling, K., Birkemeyer, E., Thiis-Evensen, E., Biagini, M., Gronbaek, H., Soveri, L.M., Olsen, I.H., Federspiel, B., Assmus, J., Janson, E.T., Knigge, U., 2013. Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study. Ann. Oncol. 24, 152-160.
  • Vilallonga, R., Espín, B.E., López, C.M., Landolfi, S., Armengol, C.M., 2008. Neuroendocrine carcinomas of the colon and rectum. A unit’s experience over six years. Rev. Esp. Enferm. Dig. 100, 11-16.
  • Zhang, X., Ma, L., Bao, H., Zhang, J., Wang, Z., Gong, P., 2014. Clinical, pathological and prognostic characteristics of gastroenteropancreatic neuroendocrine neoplasms in China: a retrospective study. BMC. Endocr. Disord. 14, 54.
Birincil Dil en
Bölüm Case Report
Yazarlar

Yazar: Alparslan Serarslan (Sorumlu Yazar)
Kurum: ONDOKUZ MAYIS ÜNİVERSİTESİ

Yazar: Nilgun Ozbek Okumus

Yazar: Filiz Karagoz

Yazar: Mehmet Selim Nural

Yazar: Bilge Gürsel

Yazar: Deniz Meydan

Tarihler

Kabul Tarihi : 7 Nisan 2016
Yayımlanma Tarihi : 10 Ekim 2019

Bibtex @olgu sunumu { omujecm629487, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs Üniversitesi}, year = {2019}, volume = {34}, pages = {275 - 278}, doi = {}, title = {Neuroendocrine carcinoma of the rectum}, key = {cite}, author = {Serarslan, Alparslan and Ozbek Okumus, Nilgun and Karagoz, Filiz and Nural, Mehmet Selim and Gürsel, Bilge and Meydan, Deniz} }
APA Serarslan, A , Ozbek Okumus, N , Karagoz, F , Nural, M , Gürsel, B , Meydan, D . (2019). Neuroendocrine carcinoma of the rectum. Journal of Experimental and Clinical Medicine , 34 (4) , 275-278 . Retrieved from https://dergipark.org.tr/tr/pub/omujecm/issue/49245/629487
MLA Serarslan, A , Ozbek Okumus, N , Karagoz, F , Nural, M , Gürsel, B , Meydan, D . "Neuroendocrine carcinoma of the rectum". Journal of Experimental and Clinical Medicine 34 (2019 ): 275-278 <https://dergipark.org.tr/tr/pub/omujecm/issue/49245/629487>
Chicago Serarslan, A , Ozbek Okumus, N , Karagoz, F , Nural, M , Gürsel, B , Meydan, D . "Neuroendocrine carcinoma of the rectum". Journal of Experimental and Clinical Medicine 34 (2019 ): 275-278
RIS TY - JOUR T1 - Neuroendocrine carcinoma of the rectum AU - Alparslan Serarslan , Nilgun Ozbek Okumus , Filiz Karagoz , Mehmet Selim Nural , Bilge Gürsel , Deniz Meydan Y1 - 2019 PY - 2019 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 275 EP - 278 VL - 34 IS - 4 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2016 ER -
EndNote %0 Journal of Experimental and Clinical Medicine Neuroendocrine carcinoma of the rectum %A Alparslan Serarslan , Nilgun Ozbek Okumus , Filiz Karagoz , Mehmet Selim Nural , Bilge Gürsel , Deniz Meydan %T Neuroendocrine carcinoma of the rectum %D 2019 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 34 %N 4 %R %U
ISNAD Serarslan, Alparslan , Ozbek Okumus, Nilgun , Karagoz, Filiz , Nural, Mehmet Selim , Gürsel, Bilge , Meydan, Deniz . "Neuroendocrine carcinoma of the rectum". Journal of Experimental and Clinical Medicine 34 / 4 (Ekim 2019): 275-278 .
AMA Serarslan A , Ozbek Okumus N , Karagoz F , Nural M , Gürsel B , Meydan D . Neuroendocrine carcinoma of the rectum. J. Exp. Clin. Med.. 2019; 34(4): 275-278.
Vancouver Serarslan A , Ozbek Okumus N , Karagoz F , Nural M , Gürsel B , Meydan D . Neuroendocrine carcinoma of the rectum. Journal of Experimental and Clinical Medicine. 2019; 34(4): 278-275.