Araştırma Makalesi
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Yıl 2018, Cilt 35, Sayı 2, 35 - 39, 25.10.2019

Öz

Kaynakça

  • Ref 1. Dawson, W. W., Trick, G. L., Litzkow, C. A., 1979. Improved electrode for electroretinography. Invest Ophthalmol Vis Sci. 18, 988-991.Ref 2.Fylan, F., Edson, A. S., Harding, G. F., 1999. Clinical significance of EEG abnormalities during photic stimulation in patients with photosensitive epilepsy. Epilepsia. 40, 370-372.Ref 3. Gotoh Y, Machida S, Tazawa Y., 2004. Selective loss of the photopic negative response in patients with optic nerve atrophy. Arch Ophthalmol. 122, 341-346.Ref 4. Harrison, J. M., Glickman, R. D., Ballentine, C. S., Trigo, Y., Pena, M. A., Kurian, P., Najvar, L.K., Kumar, N., Patel, A. H., Sponsel, W. E., Graybill, J. R., Lloyd, W. C., Miller, M. M. Paris, G. Trujillo, F. Miller, A. Melendez, R., 2005. Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits. Doc Ophthalmol. 110, 37-55.Ref 5. Heynen H, Wachtmeister L, van Norren D, 1985. Origin of the oscillatory potentials in the primate retina. Vision Res. 25, 1365-1373.Ref 6. Hood DC, Birch DG., 1996. Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: applications and methods. Doc Ophthalmol. 92, 253-267.Ref 7. Huang, W., Collette, W., Twamley, M., Aguirre, S. A., Sacaan, A., 2015. Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats. Toxicol Appl Pharmacol. 289, 525-533.Ref 8. Perlman, I., 2009. Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques. Doc Ophthalmol. 118, 3-28.Ref 9. Rangaswamy NV, Frishman LJ, Dorotheo EU, Schiffman JS, Bahrani HM, Tang RA., 2004. Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest Ophthalmol Vis Sci. 45, 3827-3837.Ref 10. Rosolen SG, Rigaudiere F, LeGargasson JF, et al., 2004. Comparing the photopic ERG i-wave in different species. Vet Ophthalmol. 7, 189-192.Ref 11. Rosolen SG, Rigaudiere F, Le Gargasson JF, Brigell MG, 2005. Recommendations for a toxicological screening ERG procedure in laboratory animals. Doc Ophthalmol. 110, 57-66.Ref 12. Rosolen, S. G., Kolomiets, B., Kolomiets, B., Varela, O., Picaud, S., 2008. Retinal electrophysiology for toxicology studies: applications and limits of ERG in animals and ex vivo recordings. Exp Toxicol Pathol. 60, 17-32.Ref 13. Rousseau S, McKerral M, Lachapelle P.,1996. The i-wave: bridging flash and pattern electroretinography. Electroencephalogr Clin Neurophysiol Suppl. 46, 165-171.Ref 14. Viswanathan S, Frishman LJ, Robson JG, Walters JW.,2001. The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci. 42, 514-522.Ref 15. Wachtmeister L., 1987. Basic research and clinical aspects of the oscillatory potentials of the electroretinogram. Doc Ophthalmol. 66, 187-194.

Alternative method in experimental ERG for retinal toxicity

Yıl 2018, Cilt 35, Sayı 2, 35 - 39, 25.10.2019

Öz

We aimed to define a cost-effective and alternative method for experimental electroretinography (ERG) in rabbits. The trigger input port of data acquisition device was connected to output port of an unemployed EEG device. The exposure area of photic stimulator was firmly covered by Wratten neutral density filters with variable optical densities(ODs). Different optical transmissions were obtained by putting more than one filter over the other one. The illumination of the area at the level of rabbit eye was measured by a luminometer in photic stimulations. ERG was performed to the both eyes of three albino rabbits in scotopic and photopic conditions at the baseline. Intravitreal saline injections were performed in right eyes of the rabbits. ERG and ophthalmologic examination were repeated one week later. ERG responses were obtained by short-duration light stimuli with different strengths in scotopic (-2.69; -1.69; 0.00; 0.30; 0.69; 0.90; 1.10; 1.30; 1.69; 2.00 log stimulus energy (log cd.s/m²)) and in photopic conditions (1.3; 1.69; 2.0; 2.10; 2.30 log stimulus energy (log cd.s/m²)). Although minimal decays in amplitudes of a- and b- waves were detected after saline injection, there was no significant difference between baseline and after injection for the stimulus-response time of a- and b- waves (p>0.05). An unemployed EEG device can be effectively used for photic stimulation in experimental ERG in the studies of retinal toxicity.

Kaynakça

  • Ref 1. Dawson, W. W., Trick, G. L., Litzkow, C. A., 1979. Improved electrode for electroretinography. Invest Ophthalmol Vis Sci. 18, 988-991.Ref 2.Fylan, F., Edson, A. S., Harding, G. F., 1999. Clinical significance of EEG abnormalities during photic stimulation in patients with photosensitive epilepsy. Epilepsia. 40, 370-372.Ref 3. Gotoh Y, Machida S, Tazawa Y., 2004. Selective loss of the photopic negative response in patients with optic nerve atrophy. Arch Ophthalmol. 122, 341-346.Ref 4. Harrison, J. M., Glickman, R. D., Ballentine, C. S., Trigo, Y., Pena, M. A., Kurian, P., Najvar, L.K., Kumar, N., Patel, A. H., Sponsel, W. E., Graybill, J. R., Lloyd, W. C., Miller, M. M. Paris, G. Trujillo, F. Miller, A. Melendez, R., 2005. Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits. Doc Ophthalmol. 110, 37-55.Ref 5. Heynen H, Wachtmeister L, van Norren D, 1985. Origin of the oscillatory potentials in the primate retina. Vision Res. 25, 1365-1373.Ref 6. Hood DC, Birch DG., 1996. Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: applications and methods. Doc Ophthalmol. 92, 253-267.Ref 7. Huang, W., Collette, W., Twamley, M., Aguirre, S. A., Sacaan, A., 2015. Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats. Toxicol Appl Pharmacol. 289, 525-533.Ref 8. Perlman, I., 2009. Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques. Doc Ophthalmol. 118, 3-28.Ref 9. Rangaswamy NV, Frishman LJ, Dorotheo EU, Schiffman JS, Bahrani HM, Tang RA., 2004. Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina. Invest Ophthalmol Vis Sci. 45, 3827-3837.Ref 10. Rosolen SG, Rigaudiere F, LeGargasson JF, et al., 2004. Comparing the photopic ERG i-wave in different species. Vet Ophthalmol. 7, 189-192.Ref 11. Rosolen SG, Rigaudiere F, Le Gargasson JF, Brigell MG, 2005. Recommendations for a toxicological screening ERG procedure in laboratory animals. Doc Ophthalmol. 110, 57-66.Ref 12. Rosolen, S. G., Kolomiets, B., Kolomiets, B., Varela, O., Picaud, S., 2008. Retinal electrophysiology for toxicology studies: applications and limits of ERG in animals and ex vivo recordings. Exp Toxicol Pathol. 60, 17-32.Ref 13. Rousseau S, McKerral M, Lachapelle P.,1996. The i-wave: bridging flash and pattern electroretinography. Electroencephalogr Clin Neurophysiol Suppl. 46, 165-171.Ref 14. Viswanathan S, Frishman LJ, Robson JG, Walters JW.,2001. The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci. 42, 514-522.Ref 15. Wachtmeister L., 1987. Basic research and clinical aspects of the oscillatory potentials of the electroretinogram. Doc Ophthalmol. 66, 187-194.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Clinical Research
Yazarlar

Volkan YETER> (Sorumlu Yazar)
FACULTY OF MEDICINE
Türkiye


Osman SAYIN>
KONYA EĞİTİM VE ARAŞTIRMA HASTANESİ
Türkiye


Yüksel SÜLLÜ>
FACULTY OF MEDICINE
Türkiye

Yayımlanma Tarihi 25 Ekim 2019
Başvuru Tarihi 4 Aralık 2018
Kabul Tarihi 16 Ekim 2019
Yayınlandığı Sayı Yıl 2018, Cilt 35, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { omujecm492087, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs Üniversitesi}, year = {2019}, volume = {35}, number = {2}, pages = {35 - 39}, title = {Alternative method in experimental ERG for retinal toxicity}, key = {cite}, author = {Yeter, Volkan and Sayın, Osman and Süllü, Yüksel} }
APA Yeter, V. , Sayın, O. & Süllü, Y. (2019). Alternative method in experimental ERG for retinal toxicity . Journal of Experimental and Clinical Medicine , 35 (2) , 35-39 . Retrieved from https://dergipark.org.tr/tr/pub/omujecm/issue/49524/492087
MLA Yeter, V. , Sayın, O. , Süllü, Y. "Alternative method in experimental ERG for retinal toxicity" . Journal of Experimental and Clinical Medicine 35 (2019 ): 35-39 <https://dergipark.org.tr/tr/pub/omujecm/issue/49524/492087>
Chicago Yeter, V. , Sayın, O. , Süllü, Y. "Alternative method in experimental ERG for retinal toxicity". Journal of Experimental and Clinical Medicine 35 (2019 ): 35-39
RIS TY - JOUR T1 - Alternative method in experimental ERG for retinal toxicity AU - VolkanYeter, OsmanSayın, YükselSüllü Y1 - 2019 PY - 2019 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 35 EP - 39 VL - 35 IS - 2 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2019 ER -
EndNote %0 Journal of Experimental and Clinical Medicine Alternative method in experimental ERG for retinal toxicity %A Volkan Yeter , Osman Sayın , Yüksel Süllü %T Alternative method in experimental ERG for retinal toxicity %D 2019 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 35 %N 2 %R %U
ISNAD Yeter, Volkan , Sayın, Osman , Süllü, Yüksel . "Alternative method in experimental ERG for retinal toxicity". Journal of Experimental and Clinical Medicine 35 / 2 (Ekim 2019): 35-39 .
AMA Yeter V. , Sayın O. , Süllü Y. Alternative method in experimental ERG for retinal toxicity. J. Exp. Clin. Med.. 2019; 35(2): 35-39.
Vancouver Yeter V. , Sayın O. , Süllü Y. Alternative method in experimental ERG for retinal toxicity. Journal of Experimental and Clinical Medicine. 2019; 35(2): 35-39.
IEEE V. Yeter , O. Sayın ve Y. Süllü , "Alternative method in experimental ERG for retinal toxicity", Journal of Experimental and Clinical Medicine, c. 35, sayı. 2, ss. 35-39, Eki. 2019