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A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma

Yıl 2018, Cilt 35, Sayı 2, 49 - 52, 25.10.2019

Öz

Composite tumor in the adrenal medulla is a rare tumor containing endocrine and neural components. Pheochromocytoma together with ganglioneuroma combination is the most common compound tumor in the adrenal medulla. Pheochromocytoma originates from the chromaffin cells in adrenal medulla and the ganglioneuroma originates from autonomic ganglion cells. A 49-years-old male patient refers to hospital with the complaint of abdominal pain which had started 1month ago. A mass was detected in his right adrenal gland, and he underwent right adrenalectomy. Macroscopic study of the adrenalectomy ma- terial section revealed a 7x5x4.5 cm dark brown-yellow mass. Histopatholog- ical studies revealed that the tumor was consisted of two components 1) areas compatible with pheochromocytoma characterized by islands of polygonal cells with eosinophilic cytoplasm, round-oval nucleus and a prominent nucleolus, and forming small nodules with well-defined margins in a fibrovascular stroma and 2) mature ganglion cells scattered in a stroma with Schwann-like cells. In immunohistochemical study, pheochromocytoma foci were stained positive for chromogranin, synaptophysin and tyrosine hydroxylase. Schwann and ganglion cells were stained positive with S100. On the basis of histomorphological and immunohistochemical findings, the patient diagnosed with compound tumor of pheochromocytoma and ganglioneuroma. Although ganglioneuroma is encoun- tered as a rare tumor, it should be kept in mind in the differential diagnosis of the adrenal masses. 

Kaynakça

  • Choi, E.K., Kim, W.H., Park, K.Y., 2006. A Case of a Composite Adrenal Medullary Tumor of Pheochromocytoma and Ganglioneuroma Masquerading as Acute Pancreatitis. The Korean Journal of Internal Medicine. 2 (21), 141-145.
  • Comstock, J.M., Willmore-Payne, C., Holden, J.A., Coffin, C.M., 2009. Composite pheochromycitoma. A clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol. 132, 69-73.
  • Gorgel, A., Çetinkaya, D.D., Salgur, F., Demirpence, M., Yılmaz H., Karaman, E.H., Tutuncuoglu, P., Oruk, G., Bahceci, M., Sari,A.A., Altinboga, A.A. and Paker, İ., 2014. Coexistence of Gastrointestinal Stromal Tumors (GISTs) and Pheochromocytoma in Three Cases of Neurofibromatosis Type 1 (NF1) with a Review of the. Intern Med. 53, 1783-1789.
  • Gücin, Z., Geçer, M.Ö., Aksoy, B., 2003. Nörofibromatozis eşliğinde non-sporadik adrenal kompozit feokromositom. Feokromositom-ganglionörom birlikteliği. Olgu sunumu. Türk Patoloji Dergisi. 19 (1-2): 42-44.
  • Hu, J., Wu, J., Cai, L., Jiang, L., Lang, Z. et al., 2013. Retroperitoneal composite pheochromocytoma- ganglioneuroma: a case report and review of literature. Diagnostic Pathology. 8, 63.
  • Lam, K.Y., Lo, C.Y., 1999. Composite Pheochromocytoma-Ganglioneuroma of the Adrenal Gland: An Uncommon Entity with Distinctive Clinicopathologic Features. Endocr Pathol. Winter; 10 (4),343-352.
  • Mahajan, H., Lee, D., Sharma, R., Chin, P. et al., 2010. Composite phaeocromcytoma-ganglioneuroma, an uncommon entity: report of two cases. Pathology. 3 (42), 295-297.
  • Menon, S., Manajan, P., Desai, S.B., 2011. Composite adrenal medullary tumor: A rare cause of hypertension in a young male. Urol Ann. 3 (1), 36-38.
  • Rai, R., Gajanthody, S., Jayaram, J., Chauhry, R.K., 2012. Composite pheochromycitoma. South Asian J Cancer. 1 (2), 98-99. Rao, R.N., Singla, N., Yadav, K., 2013. Composite pheochromycitoma-ganglioneuroma of the adrenal gland: a case report with immunohistochemical study. Urol Ann. 5 (2), 115–118.
  • Shida, T., Igawa, T., Abe, K., Hakariya, T., Takehara, K., Onita, T. and Sak, H., 2015. Composite pheochromocytoma of the adrenal gland: a case series. BMC Res Notes. 8, 257.

Yıl 2018, Cilt 35, Sayı 2, 49 - 52, 25.10.2019

Öz

Kaynakça

  • Choi, E.K., Kim, W.H., Park, K.Y., 2006. A Case of a Composite Adrenal Medullary Tumor of Pheochromocytoma and Ganglioneuroma Masquerading as Acute Pancreatitis. The Korean Journal of Internal Medicine. 2 (21), 141-145.
  • Comstock, J.M., Willmore-Payne, C., Holden, J.A., Coffin, C.M., 2009. Composite pheochromycitoma. A clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol. 132, 69-73.
  • Gorgel, A., Çetinkaya, D.D., Salgur, F., Demirpence, M., Yılmaz H., Karaman, E.H., Tutuncuoglu, P., Oruk, G., Bahceci, M., Sari,A.A., Altinboga, A.A. and Paker, İ., 2014. Coexistence of Gastrointestinal Stromal Tumors (GISTs) and Pheochromocytoma in Three Cases of Neurofibromatosis Type 1 (NF1) with a Review of the. Intern Med. 53, 1783-1789.
  • Gücin, Z., Geçer, M.Ö., Aksoy, B., 2003. Nörofibromatozis eşliğinde non-sporadik adrenal kompozit feokromositom. Feokromositom-ganglionörom birlikteliği. Olgu sunumu. Türk Patoloji Dergisi. 19 (1-2): 42-44.
  • Hu, J., Wu, J., Cai, L., Jiang, L., Lang, Z. et al., 2013. Retroperitoneal composite pheochromocytoma- ganglioneuroma: a case report and review of literature. Diagnostic Pathology. 8, 63.
  • Lam, K.Y., Lo, C.Y., 1999. Composite Pheochromocytoma-Ganglioneuroma of the Adrenal Gland: An Uncommon Entity with Distinctive Clinicopathologic Features. Endocr Pathol. Winter; 10 (4),343-352.
  • Mahajan, H., Lee, D., Sharma, R., Chin, P. et al., 2010. Composite phaeocromcytoma-ganglioneuroma, an uncommon entity: report of two cases. Pathology. 3 (42), 295-297.
  • Menon, S., Manajan, P., Desai, S.B., 2011. Composite adrenal medullary tumor: A rare cause of hypertension in a young male. Urol Ann. 3 (1), 36-38.
  • Rai, R., Gajanthody, S., Jayaram, J., Chauhry, R.K., 2012. Composite pheochromycitoma. South Asian J Cancer. 1 (2), 98-99. Rao, R.N., Singla, N., Yadav, K., 2013. Composite pheochromycitoma-ganglioneuroma of the adrenal gland: a case report with immunohistochemical study. Urol Ann. 5 (2), 115–118.
  • Shida, T., Igawa, T., Abe, K., Hakariya, T., Takehara, K., Onita, T. and Sak, H., 2015. Composite pheochromocytoma of the adrenal gland: a case series. BMC Res Notes. 8, 257.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Case Report
Yazarlar

Seda GÜN> (Sorumlu Yazar)

0000-0002-6652-4582


Duygu KURU Bu kişi benim


Mehmet KEFELİ Bu kişi benim

Yayımlanma Tarihi 25 Ekim 2019
Başvuru Tarihi 13 Aralık 2015
Kabul Tarihi 5 Mart 2016
Yayınlandığı Sayı Yıl 2018, Cilt 35, Sayı 2

Kaynak Göster

Bibtex @olgu sunumu { omujecm634072, journal = {Journal of Experimental and Clinical Medicine}, issn = {1309-4483}, eissn = {1309-5129}, address = {}, publisher = {Ondokuz Mayıs Üniversitesi}, year = {2019}, volume = {35}, number = {2}, pages = {49 - 52}, title = {A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma}, key = {cite}, author = {Gün, Seda and Kuru, Duygu and Kefeli, Mehmet} }
APA Gün, S. , Kuru, D. & Kefeli, M. (2019). A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma . Journal of Experimental and Clinical Medicine , 35 (2) , 49-52 . Retrieved from https://dergipark.org.tr/tr/pub/omujecm/issue/49524/634072
MLA Gün, S. , Kuru, D. , Kefeli, M. "A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma" . Journal of Experimental and Clinical Medicine 35 (2019 ): 49-52 <https://dergipark.org.tr/tr/pub/omujecm/issue/49524/634072>
Chicago Gün, S. , Kuru, D. , Kefeli, M. "A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma". Journal of Experimental and Clinical Medicine 35 (2019 ): 49-52
RIS TY - JOUR T1 - A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma AU - SedaGün, DuyguKuru, MehmetKefeli Y1 - 2019 PY - 2019 N1 - DO - T2 - Journal of Experimental and Clinical Medicine JF - Journal JO - JOR SP - 49 EP - 52 VL - 35 IS - 2 SN - 1309-4483-1309-5129 M3 - UR - Y2 - 2016 ER -
EndNote %0 Journal of Experimental and Clinical Medicine A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma %A Seda Gün , Duygu Kuru , Mehmet Kefeli %T A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma %D 2019 %J Journal of Experimental and Clinical Medicine %P 1309-4483-1309-5129 %V 35 %N 2 %R %U
ISNAD Gün, Seda , Kuru, Duygu , Kefeli, Mehmet . "A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma". Journal of Experimental and Clinical Medicine 35 / 2 (Ekim 2019): 49-52 .
AMA Gün S. , Kuru D. , Kefeli M. A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma. J. Exp. Clin. Med.. 2019; 35(2): 49-52.
Vancouver Gün S. , Kuru D. , Kefeli M. A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma. Journal of Experimental and Clinical Medicine. 2019; 35(2): 49-52.
IEEE S. Gün , D. Kuru ve M. Kefeli , "A composite tumor in the adrenal gland: Pheochromocytoma and ganglioneuroma", Journal of Experimental and Clinical Medicine, c. 35, sayı. 2, ss. 49-52, Eki. 2019