Clinical impact of lung age on postoperative complications and prognosis in patients aged > 60 years with non-small cell lung cancer and no comorbidities treated by anatomical resection

Year 2019, Volume: 36 Issue: 2, 49 - 53, 25.12.2019

Tuba Apaydın , Yüksel Bek , Ahmet Başoğlu , Yasemin Büyükkarabacak , Burçin Çelik , Ayşen Taslak Şengül

Abstract

Lung age formula proposed by Morris and Temple aimed to contribute toward smoking cessation programme and it was developed by Japanese Respiratory Society. It is considered as an important useful factor for predicting postopera-tive respiratory complications and survival in surgically treated patients with non small cell lung cancer. As the first for Turkish society, we aimed to evalu-ate clinical impact of lung age on postoperative complications in patients with NSCLC aged > 60 y. Survey included anatomically resected 80 NSCLC patients aged > 60 y in OMU Thoracic Surgery Clinic between years 2005 - 2015. Three groups were created using age groups <0, 0-10, >10, calculated as the difference between lung age and true age. Lung age was calculated according to Japanese Respiratory Society formula. Preoperative, intraopera-tive and postoperative prognostic factors were compared between three groups. Patient numbers in three groups were 18, 17 and 45. In preoperative factors gender, smoking, FEV1, FVC, SCC was related to lung age; postoperative respiratory complications and postoperative readmission related to respi-ratory complications were seen to have significant association with lung age. Lung age can be used as a clinical parameter to predict postoperative complication risk for NSCLC.

Keywords

lung age, age gap, NSCLC, anatomic resection

References

• 1. Morris JF, Temple W. Spirometric “lung age” estimation for motivating smoking cessation. Prev Med 1985; 14:655.
• 2. Weinberger, Chronic Obstructive Pulmonary Disease, Principles of Pulmonary Medicine, 4.th edition 1992.
• 3. Aizawa H., Kudoh S. Proposal for ‘lung age’ to explain impairment of pulmonary function. Prog Med 2007; 27:2418.
• 4. Yamaguchi K, Onizawa S, Tsuji T, Aoshiba K, Nagai A. How to evaluate “spirometric” lung age – what method is approvable? Respir Physiol Neurobiol 2011; 178; pp. 349–3512.
• 5. Ogawa F, Miyata S, Nakashima H, Matsui Y, Shiomi K, Iyoda A, Satoh Y. Clinical impact of lung age on postoperative complications in non small cell lung cancer patients aged > 70 y. Journal of Surgical Research 2014; 188 ; 373-380.
• 6. Haruki T, Nakamura H, Taniguchi Y, Miwa K, Adachi Y, Fujioka S. “Lung age” predicts post-operative complications and survival in lung cancer patients. Respirology 2010; 15:495.
• 7. Fumihiro Ogawa MD, PhDad Yukitoshi Satoh MD, PhDb AkiraIyoda MD, PhDc Hideki Amano MD, PhDa Yuji Kumagai MD, PhDad Masataka Majima MD, PhDa. Clinical impact of lung age on postoperative readmission in non small cell lung cancer. Journal of Surgical Research 2014 ; 1-7.